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公开(公告)号：EP2552961B1
公开(公告)日：2017-12-20
申请号：EP11763357.8
申请日：2011-03-30
发明人： ALMAGRO, Juan, Carlos , BRANIGAN, Patrick , KANE, Colleen , STROHL, William , TAUDTE, Susann , TORNETTA, Mark , WHEELER, John
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
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公开(公告)号：EP2627356A2
公开(公告)日：2013-08-21
申请号：EP11833202.2
申请日：2011-10-10
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07H21/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
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公开(公告)号：EP2627356B1
公开(公告)日：2019-05-22
申请号：EP11833202.2
申请日：2011-10-10
发明人： ALMAGRO, Juan, Carlos , DUBELL, William , FRANSSON, Johan , PARDINAS, Jose , RAGHUNATHAN, Gopalan
IPC分类号： A61K39/395 , C12P21/08
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公开(公告)号：EP2493506B1
公开(公告)日：2019-04-10
申请号：EP10827516.5
申请日：2010-10-29
发明人： NASO, Michael , SWEET, Raymond , LUO, Jinquan , WU, Sheng-jiun , ELLOSO, Merle , DUCATA, Daniela, Della , RAUCHENBERGER, Robert , RUTZ, Mark , ALMAGRO, Juan, Carlos , TAUDTE, Susann , WU, Bingyuan , OBMOLOVA, Galina , MALIA, Thomas
IPC分类号： A61K39/395 , C07K16/00 , C07K16/24
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公开(公告)号：EP2686350A1
公开(公告)日：2014-01-22
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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公开(公告)号：EP2686350B1
公开(公告)日：2018-04-25
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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公开(公告)号：EP2552961A1
公开(公告)日：2013-02-06
申请号：EP11763357.8
申请日：2011-03-30
发明人： ALMAGRO, Juan, Carlos , BRANIGAN, Patrick , KANE, Colleen , STROHL, William , TAUDTE, Susann , TORNETTA, Mark , WHEELER, John
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to target binding members (e.g., antibodies) that bind a specified epitope of human IL-25. The invention also relates to target binding members (e.g., antibodies) that comprise one or more humanized antibody VL domain sequences and bind IL-25. The invention further relates to compositions comprising target binding members (e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).
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公开(公告)号：EP2493506A2
公开(公告)日：2012-09-05
申请号：EP10827516.5
申请日：2010-10-29
发明人： NASO, Michael , SWEET, Raymond , LUO, Jinquan , WU, Sheng-jiun , ELLOSO, Merle , DUCATA, Daniela, Della , RAUCHENBERGER, Robert , RUTZ, Mark , ALMAGRO, Juan, Carlos , TAUDTE, Susann , WU, Bingyuan , OBMOLOVA, Galina , MALIA, Thomas
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/244 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Interleukin-17A (IL-17A) antibody antagonists, polynucleotides encoding IL-17A antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
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