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公开(公告)号：EP2686350B1
公开(公告)日：2018-04-25
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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公开(公告)号：EP4326323A1
公开(公告)日：2024-02-28
申请号：EP22792260.6
申请日：2022-04-18
发明人： SINGH, Sanjaya , CHI, Ellen , CASE, Martin , ZHOU, Hong, Mimi , HYUN, Linus , FURMAN, Jennifer , LACOMBE, Ann
IPC分类号： A61K39/395 , A61P35/00 , C07K16/46 , C07K19/00 , C12N15/09
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公开(公告)号：EP2686350A1
公开(公告)日：2014-01-22
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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