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公开(公告)号：EP2686350B1
公开(公告)日：2018-04-25
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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公开(公告)号：EP2686350A1
公开(公告)日：2014-01-22
申请号：EP12757251.9
申请日：2012-03-12
发明人： ALMAGRO, Juan, Carlos , ANDERSON, Glenn, Mark , CHI, Ellen , MARTINEZ, Christian , RAGHUNATHAN, Gopalan , SWANSON, Ronald , TEPLYAKOV, Alexey , TSE, Kam-fai , WU, Sheng-jium , ZHOU, Hong, Mimi
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
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公开(公告)号：EP2488867A2
公开(公告)日：2012-08-22
申请号：EP10824085.4
申请日：2010-10-14
CPC分类号： C07K16/00 , C07K16/248 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The invention relates to methods of affinity maturing antibodies.
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公开(公告)号：EP2488867B1
公开(公告)日：2020-09-30
申请号：EP10824085.4
申请日：2010-10-14
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公开(公告)号：EP2627356B1
公开(公告)日：2019-05-22
申请号：EP11833202.2
申请日：2011-10-10
发明人： ALMAGRO, Juan, Carlos , DUBELL, William , FRANSSON, Johan , PARDINAS, Jose , RAGHUNATHAN, Gopalan
IPC分类号： A61K39/395 , C12P21/08
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公开(公告)号：EP1824514B1
公开(公告)日：2015-03-04
申请号：EP05852564.3
申请日：2005-11-30
发明人： CARTON, Jill , CUNNINGHAM, Mark , DAS, Anuk , DUFFY, Karen , KNIGHT, David, M. , LAMB, Roberta , MBOW, Mouhamadou, L. , RAGHUNATHAN, Gopalan , SAN MATEO, Lani , SARISKY, Robert, T. , STOWELL, Nicole , SWEET, Raymond , ZHAO, Shanrong , CHEN, Shizhong , GILES-KOMAR, Jill , PICHA, Kristen , STOJANOVIC-SUSULIC, Vedrana , GOLETZ, Theresa, J.
IPC分类号： A61K39/42 , A61K39/395 , A61K38/16 , C07K14/52 , C07K14/705 , C07K16/28 , A61P37/00 , A61P31/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP1919951B1
公开(公告)日：2015-01-28
申请号：EP06774701.4
申请日：2006-07-27
CPC分类号： C07K16/241 , C07K16/464 , C07K2317/24 , C07K2317/55 , C07K2317/92
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