公开(公告)号：EP2888286A1

公开(公告)日：2015-07-01

申请号：EP13830990.1

申请日：2013-08-20

申请人： Ortho-Clinical Diagnostics, Inc. ,  Janssen Pharmaceutica, N.V.

发明人： HRYHORENKO, Eric ,  SANKARAN, Banumathi ,  DECORY, Thomas R. ,  TUBBS, Theresa ,  COLT, Linda ,  REMMERIE, Bart M. ,  SALTER, Rhys ,  DONAHUE, Matthew Garrett ,  GONG, Yong

IPC分类号： C07K16/44 ,  C07K14/00 ,  A61K31/551

CPC分类号： C07K16/44 ,  G01N33/94 ,  G01N33/9466

摘要： Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2888592A2

公开(公告)日：2015-07-01

申请号：EP13831507.2

申请日：2013-08-20

申请人： Ortho-Clinical Diagnostics, Inc. ,  Janssen Pharmaceutica, N.V.

发明人： HRYHORENKO, Eric ,  SANKARAN, Banumathi ,  DECORY, Thomas R. ,  TUBBS, Theresa ,  COLT, Linda ,  REMMERIE, Bart M. ,  SALTER, Rhys ,  DONAHUE, Matthew Garrett ,  GONG, Yong

IPC分类号： G01N33/53

CPC分类号： G01N33/9466 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/94

摘要： Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including muitiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2888257A1

公开(公告)日：2015-07-01

申请号：EP13753777.5

申请日：2013-08-20

申请人： Janssen Pharmaceutica, N.V. ,  ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： DONAHUE, Matthew Garrett ,  GONG, Yong ,  SALTER, Rhys ,  HRYHORENKO, Eric ,  DECORY, Thomas R. ,  REMMERIE, Bart M. ,  SANKARAN, Banumathi

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D281/16 ,  G01N33/53 ,  A61K47/48 ,  A61K31/554 ,  A61P25/00

CPC分类号： G01N33/5308 ,  A61K47/64 ,  A61K47/643 ,  A61K47/646 ,  C07D281/16 ,  C07D417/12 ,  C07D417/14

摘要： The invention relates to compounds of Formula I, wherein R
1 , R
2 , and R
3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成衍生自喹硫平的新缀合物和免疫原。 本发明还涉及喹硫平半抗原和蛋白质的缀合物。

公开(公告)号：EP2888590A2

公开(公告)日：2015-07-01

申请号：EP13831110.5

申请日：2013-08-20

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC. ,  Janssen Pharmaceutica, N.V.

发明人： HRYHORENKO, Eric ,  SANKARAN, Banumathi ,  DECORY, Thomas R. ,  TUBBS, Theresa ,  COLT, Linda ,  REMMERIE, Bart M. ,  SALTER, Rhys ,  DONAHUE, Matthew Garrett ,  GONG, Yong

IPC分类号： G01N33/53

摘要： Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2888269A1

公开(公告)日：2015-07-01

申请号：EP13753774.2

申请日：2013-08-20

申请人： Janssen Pharmaceutica, N.V. ,  ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： DONAHUE, Matthew Garrett ,  GONG, Yong ,  SALTER, Rhys ,  HRYHORENKO, Eric ,  DECORY, Thomas R. ,  REMMERIE, Bart M. ,  SANKARAN, Banumathi

IPC分类号： C07D495/04 ,  A61K47/48 ,  A61K31/554 ,  G01N33/53

CPC分类号： C07D495/04 ,  A61K47/643 ,  A61K47/646 ,  C07K14/47 ,  C07K14/77

摘要： The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在说明书中定义，可用于合成衍生自奥氮平的新偶联物和免疫原。 本发明还涉及奥氮平半抗原和蛋白质的缀合物。