公开(公告)号：EP1899319A2

公开(公告)日：2008-03-19

申请号：EP06772478.1

申请日：2006-06-07

申请人： Janssen Pharmaceutica NV

发明人： BAINDUR, Nand ,  GAUL, Michael, David ,  KREUTTER, Kevin, Douglas ,  BAUMANN, Christian, Andrew ,  XU, Guozhang ,  KIM, Alexander, J. ,  ZHAO, Bao-Ping

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04

摘要： The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.

公开(公告)号：EP2968258B1

公开(公告)日：2020-02-12

申请号：EP14717254.8

申请日：2014-03-07

申请人： Janssen Pharmaceutica NV

发明人： GAUL, Micheal ,  KUO, Gee-Hong ,  XU, Guozhang ,  ZHAO, Bao-Ping

IPC分类号： C07D407/10 ,  C07D405/10 ,  C07D409/10 ,  C07D409/14 ,  C07D417/10 ,  A61K31/351 ,  A61P3/10