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公开(公告)号：EP2235008B1
公开(公告)日：2016-03-16
申请号：EP08855867.1
申请日：2008-12-05
发明人： JONCKERS, Tim Hugo Maria , SCHEPENS, Wim Bert Griet , HACHÉ, Geerwin Yvonne Paul , HALLENBERGER, Beate Sabine , SASAKI, Jennifer Chiyomi , BAUMEISTER, Judith Eva , VAN 'T KLOOSTER, Gerben Albert Eleutherius
IPC分类号： C07D417/12 , C07D417/14 , C07D277/82 , A61K31/427 , A61P31/18
CPC分类号： C07D417/14 , C07D277/82 , C07D417/12
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公开(公告)号：EP2997019B1
公开(公告)日：2018-08-08
申请号：EP14724109.5
申请日：2014-05-16
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D333/38 , C07D409/12
CPC分类号： C07D333/38 , C07D409/12
摘要： Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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3.发明授权4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权4,4-二取代-1,4-二氢嘧啶及其作为药物用于乙型肝炎治疗
公开(公告)号：EP2800742B1
公开(公告)日：2016-04-06
申请号：EP13700017.0
申请日：2013-01-04
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , ROMBOUTS,Geert , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D239/22 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D491/107 , A61K31/506 , A61K31/527 , A61P31/20
CPC分类号： C07D239/22 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/527 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/10 , C07D491/107
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公开(公告)号：EP3102572B1
公开(公告)日：2018-10-24
申请号：EP15704502.2
申请日：2015-02-05
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , ROMBOUTS, Geert , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D405/14 , C07D401/12
CPC分类号： C07D405/14 , A61K31/4439 , A61K31/4545 , A61K45/06 , C07D401/12 , C07D401/14
摘要： The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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5.发明公开SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开SULFAMOYLPYRROLAMIDDERIVATE及其用途作为乙肝治疗药物
公开(公告)号：EP3102572A1
公开(公告)日：2016-12-14
申请号：EP15704502.2
申请日：2015-02-05
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , ROMBOUTS, Geert , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D405/14 , C07D401/12
CPC分类号： C07D405/14 , A61K31/4439 , A61K31/4545 , A61K45/06 , C07D401/12 , C07D401/14
摘要： The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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6.发明公开SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权维生素DAVON ALS MEDIKAMENTE ZUR BEHANDLUNG VON HEPATITIS B的SULFAMOYLHINAMIDDERIVATE
公开(公告)号：EP2997019A1
公开(公告)日：2016-03-23
申请号：EP14724109.5
申请日：2014-05-16
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D333/34 , C07D409/12
CPC分类号： C07D333/38 , C07D409/12
摘要： Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 包含立体化学异构体形式的式（I）的HBV复制抑制剂及其盐，水合物，溶剂合物，其中X和R 1至R 8具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独使用或与其它HBV抑制剂组合的用途。
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7.发明授权CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权甲酰胺衍生物及其用作治疗乙型肝炎的药物
公开(公告)号：EP3060547B1
公开(公告)日：2017-10-11
申请号：EP14793047.3
申请日：2014-10-22
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , KESTELEYN, Bart Rudolf Romanie , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D207/16 , C07D209/16 , A61P31/20 , A61K31/445 , A61K31/40 , C07D405/12
CPC分类号： C07D207/16 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K45/06 , C07D207/09 , C07D211/34 , C07D211/60 , C07D405/12
摘要： The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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8.发明授权N-PHENYL-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权N-苯基 - 羧酰胺衍生物及其用作治疗乙型肝炎的药物
公开(公告)号：EP2981536B1
公开(公告)日：2017-06-14
申请号：EP14714292.1
申请日：2014-04-02
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D405/12 , C07D409/12 , C07D487/08 , C07D207/16 , C07D209/42
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/407 , A61K45/06 , C07D207/16 , C07D207/48 , C07D209/42 , C07D209/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 式（I）的HBV复制抑制剂包括立体化学异构形式及其盐，水合物，溶剂化物，其中X，R 1，R 2，R 3和R 4具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其单独或与其他HBV抑制剂组合用于HBV治疗的方法。
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9.发明公开SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开维生素DAVON ALS MEDIKAMENTE ZUR BEHANDLUNG VON HEPATITIS B的SULFAMOYLPYRROLAMIDDERIVATE
公开(公告)号：EP3121164A1
公开(公告)日：2017-01-25
申请号：EP16180180.8
申请日：2014-05-16
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , LAST, Stefaan Julien , MC GOWAN, David Craig , ROMBOUTS, Geert , VERSCHUEREN, Wim Gaston , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D207/36 , C07D207/40 , C07D403/12 , C07D405/12 , A61K31/401 , A61P31/20
摘要： Inhibitors of HBV replication of Formula (ID)
including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R a to R d and R 4 to R 6 have the meaning as defined herein.
The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.摘要翻译： 包括立体化学异构形式的式（ID）的HBV复制抑制剂及其盐，水合物，溶剂合物，其中X，R a至R d和R 4至R 6具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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10.发明公开CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权CARBOXAMIDDERIVATE UND VERWENDUNG DAVON ALS MEDIKAMENTE ZUR BEHANDLUNG VON HEPATITIS B
公开(公告)号：EP3060547A1
公开(公告)日：2016-08-31
申请号：EP14793047.3
申请日：2014-10-22
发明人： VANDYCK, Koen , HACHÉ, Geerwin Yvonne Paul , KESTELEYN, Bart Rudolf Romanie , RABOISSON, Pierre Jean-Marie Bernard
IPC分类号： C07D207/16 , C07D209/16 , A61P31/20 , A61K31/445 , A61K31/40 , C07D405/12
CPC分类号： C07D207/16 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K45/06 , C07D207/09 , C07D211/34 , C07D211/60 , C07D405/12
摘要： The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 包括立体化学异构形式及其盐，水合物，溶剂合物，其中X，R 1至R 7具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独使用或与其它HBV抑制剂组合的用途。
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