公开(公告)号：EP3889157B1

公开(公告)日：2023-07-26

申请号：EP19889945.2

申请日：2019-10-25

发明人： LEE, Minhee ,  KIM, Seon-Mi ,  KIM, Hun-Taek

IPC分类号： C07D491/20 ,  A61K31/519 ,  A61K31/527 ,  A61P5/24

公开(公告)号：EP4043463A1

公开(公告)日：2022-08-17

申请号：EP22165122.7

申请日：2018-07-13

申请人： Shionogi & Co., Ltd

发明人： NODU, Kouhei ,  TATENO, Yusuke ,  MASUDA, Kengo ,  NISHIURA, Yuji ,  SASAKI, Yoshikazu ,  NODU, KouheiHINATA, Yu

IPC分类号： C07D471/04 ,  A61K31/438 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/527 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P43/00 ,  C07D471/10 ,  C07D491/20 ,  C07D471/20 ,  C07D487/10 ,  C07D491/147

摘要： The present inventon provides the compound represented by the following formula (I):

wherein a moiety represented by formula:

is

or the like;
y is 0 or 1; R 1 is hydrogen or the like; R 2a and R 2b are taken together with an adjacent carbon atom to form ring B; ring B is a substituted or unsubstituted non-aromatic carbocycle or the like; R 3a is hydrogen or the like; R 3b is hydrogen or the like; R 4a is represented by formula:

: L 1 is a single bond or the like; L 2 is -C(=O)- or the like; L 3 is a single bond or the like; R 7 is substituted or unsubstituted alkyl or the like; R 4b is substituted or unsubstituted alkyl or the like; R 4c is each independently halogen or the like.

公开(公告)号：EP3858835A1

公开(公告)日：2021-08-04

申请号：EP20213600.8

申请日：2017-06-29

申请人： G1 Therapeutics, Inc.

发明人： STRUM, Jay, Copeland ,  JUNG, David

IPC分类号： C07D487/14 ,  A61K31/527 ,  C07D487/20 ,  A61K31/519

摘要： This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

公开(公告)号：EP3172211B1

公开(公告)日：2019-07-03

申请号：EP15825267.6

申请日：2015-07-21

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： WAN, Zehong ,  ZHANG, Xiaomin ,  WANG, Jian ,  SENDER, Matthew Robert ,  MANAS, Eric Steven ,  RIVERO, Raphael Anthony ,  PERO, Joseph E. ,  NEIPP, Christopher Ernst ,  PATEL, Vipulkumar Kantibhai

IPC分类号： C07D487/14 ,  C07D487/20 ,  C07D491/20 ,  C07D513/12 ,  A61K31/519 ,  A61K31/527 ,  A61P25/28 ,  A61P9/10

公开(公告)号：EP3484889A1

公开(公告)日：2019-05-22

申请号：EP17742971.9

申请日：2017-07-12

申请人： F. Hoffmann-La Roche AG

发明人： BIEMANS, Barbara ,  JAESCHKE, Georg ,  RICCI, Antonio ,  RUEHER, Daniel ,  O`HARA, Fionn

IPC分类号： C07D487/10 ,  A61K31/527 ,  A61P25/16

摘要： The present invention relates to compounds that may be used in the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression or diabetes type 2.

公开(公告)号：EP3366309A1

公开(公告)日：2018-08-29

申请号：EP16857427.5

申请日：2016-10-18

申请人： National University Corporation Tokyo Medical and Dental University

发明人： SHINOZAKI, Shohei ,  SHIMOKADO, Kentaro

IPC分类号： A61K45/00 ,  A23L33/10 ,  A61K8/41 ,  A61K8/43 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/63 ,  A61K8/64 ,  A61K31/131 ,  A61K31/155 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/444 ,  A61K31/4458 ,  A61K31/527 ,  A61K31/54 ,  A61K31/573 ,  A61K31/7088 ,  A61K31/713

CPC分类号： A61K31/155 ,  A23L33/10 ,  A61K8/41 ,  A61K8/43 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/496 ,  A61K8/606 ,  A61K8/63 ,  A61K8/64 ,  A61K31/131 ,  A61K31/145 ,  A61K31/197 ,  A61K31/198 ,  A61K31/435 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/573 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61P17/14 ,  A61Q7/00 ,  C12Q1/26 ,  G01N33/5008 ,  G01N2333/90254 ,  G01N2500/04

摘要： The present invention relates to provision of novel compositions that promote hair growth or hair restoration, and compositions that prevent hair loss. More specifically, compositions comprising an iNOS inhibitor as an active ingredient are provided. Advantageous affects for hair growth or hair restoration are obtained when a composition comprising an iNOS inhibitor as an active ingredient is administered to a mammal. For the iNOS inhibitor, a low-molecular compound, an antibody, or a nucleic acid drug such as an antisense oligonucleotide or siRNA may be used. A method of screening for effective substances for promotion of hair growth or hair restoration or prevention of hair loss is also provided.

公开(公告)号：EP2820021B1

公开(公告)日：2016-11-30

申请号：EP13754960.6

申请日：2013-02-28

申请人： SK Chemicals Co., Ltd.

发明人： KIM, Seon-Mi ,  KIM, Jae-Sun ,  LEE, Minhee ,  LEE, So-Young ,  LEE, Bong-Yong ,  SHIN, Young Ah ,  PARK, Euisun ,  LEE, Jung A ,  HAN, Min-Young ,  AHN, Jaeseung ,  YOO, Taekyung ,  KIM, Hun-Taek

IPC分类号： C07D471/10 ,  C07D491/10 ,  C07D491/20 ,  A61K31/527 ,  A61P35/00

CPC分类号： C07D491/20 ,  C07D471/10 ,  C07D491/10

公开(公告)号：EP2897961B1

公开(公告)日：2016-10-26

申请号：EP13771007.5

申请日：2013-09-17

申请人： Novartis AG

发明人： DILLON, Michael, Patrick ,  LINDVALL, Mika ,  POON, Daniel ,  RAMURTHY, Savithri ,  RAUNIYAR, Vivek ,  SHAFER, Cynthia ,  SUBRAMANIAN, Sharadha ,  TANNER, Huw

IPC分类号： C07D207/36 ,  C07D487/04 ,  C07D487/10 ,  A61K31/519 ,  A61K31/527 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/527 ,  A61K45/06 ,  C07D207/36 ,  C07D487/10

公开(公告)号：EP2967050A4

公开(公告)日：2016-09-28

申请号：EP14764016

申请日：2014-03-14

申请人： G1 THERAPEUTICS INC

发明人： STRUM JAY COPELAND ,  BISI JOHN EMERSON ,  ROBERTS PATRICK JOSEPH ,  TAVARES FRANCIS XAVIER

IPC分类号： A61K31/44 ,  A61K31/527 ,  A61P35/00 ,  C07D491/14

CPC分类号： A61K31/527 ,  A61K31/529 ,  A61K31/5377 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/6867 ,  A61K51/0459 ,  A61K51/0468 ,  C07D487/14

摘要： This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.

公开(公告)号：EP2427193A4

公开(公告)日：2013-04-03

申请号：EP10772372

申请日：2010-05-03

申请人： OMEROS CORP

发明人： BERGMANN JOHN E ,  CUTSHALL NEIL S ,  DEMOPULOS GREGORY A ,  FLORIO VINCENT A ,  GAITANARIS GEORGE ,  GRAY PATRICK ,  HOHMANN JOHN ,  ONRUST RENE ,  ZENG HONGKUI

IPC分类号： A61K31/50 ,  A61K31/137 ,  A61K31/195 ,  A61K31/38 ,  A61K31/415 ,  A61K31/425 ,  A61K31/433 ,  A61K31/519 ,  A61K31/527 ,  A61K45/06 ,  A61P25/14 ,  C07D471/04

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4162 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/527 ,  A61K31/542 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.