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公开(公告)号：EP4470569A1
公开(公告)日：2024-12-04
申请号：EP23746232.0
申请日：2023-01-19
Applicant: Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Senhui Medicine Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Inventor： REN, Wenming , ZHU, Lingjian , CHEN, Hao , TANG, Manping , LIN, Yuan , ZHOU, Caihong , HUANG, Jian , LIAO, Cheng
Abstract: Disclosed is an antibody-drug conjugate represented by formula (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is a glucocorticoid or a residue thereof, the glucocorticoid being selected from budesonide and ciclesonide.
Ab-(L-D) k (I)-
公开(公告)号：EP4442700A1
公开(公告)日：2024-10-09
申请号：EP22900581.4
申请日：2022-12-01
Applicant: Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Inventor： HE, Hua , CHEN, Hao , ZHANG, Feiran , XU, Jiajia , ZHANG, Qiang , CAO, Xiaoli
CPC classification number: A61K38/26 , A61K47/26 , A61K47/38 , A61K47/18 , A61P3/04 , A61P3/10 , C07K14/605
Abstract: Provided are a pharmaceutical composition of GLP-1 and GIP receptor dual agonist and the use thereof. The pharmaceutical composition has good dissolution characteristics and stability.
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3.发明公开
公开(公告)号：EP4245768A1
公开(公告)日：2023-09-20
申请号：EP21891204.6
申请日：2021-11-12
Applicant: Jiangsu Hengrui Pharmaceuticals Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd
Inventor： YE, Linmao , FAN, Yingfang , SUN, Yanyan , YU, Shuxiang , CHEN, Hao
Abstract: Provided are a pharmaceutical composition comprising a human interleukin 2 (IL-2) variant or derivative thereof and use thereof. In particular, provided are a pharmaceutical composition including a human interleukin 2 variant or derivative thereof and a pharmaceutically acceptable excipient. The pharmaceutical composition has improved high temperature, freezing and thawing, room-temperature stability, and appearance formulation reproducibility.
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