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公开(公告)号：EP4205767A1
公开(公告)日：2023-07-05
申请号：EP21860418.9
申请日：2021-08-25
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , GUAN, Zhongjun , LIANG, Shaonan , REN, Wenming , LIAO, Cheng
摘要： A drug-loaded macromolecule and a preparation method therefor, the macromolecule specifically being a dentritic polymer loaded with a drug and a pharmacokinetic modifier, and relating in particular to connecting the drug to the dentritic polymer by means of a specific linker. The present macromolecule can be used to regulate the release speed of the drug, specifically by means of the selection of linker.
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公开(公告)号：EP4374879A1
公开(公告)日：2024-05-29
申请号：EP22845463.3
申请日：2022-07-22
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Hengrui Pharmaceutical Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： SUN, Xing , YANG, Changyong , LIANG, Jindong , LIAO, Cheng
IPC分类号： A61K47/68 , C07K16/28 , A61K31/357 , A61K39/395 , A61P35/00
CPC分类号： A61K47/68 , A61K47/6803 , A61K47/6855 , A61K47/6889 , C07K16/32 , C07K2317/7320130101 , A61K2039/50520130101
摘要： A drug conjugate of an Eribulin derivative. Specifically, provided are an HER2 antibody conjugate that is formed by binding the Eribulin derivative to structural domain II of HER2, a preparation method therefor, and a pharmaceutical application thereof. The present invention further relates to a method for treating a cancer by means of administration of an antibody-drug conjugate, and a composition.
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公开(公告)号：EP4268818A1
公开(公告)日：2023-11-01
申请号：EP21909544.5
申请日：2021-12-24
申请人： Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Senhui Medicine Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： XU, Daping , YANG, Changyong , LIAO, Cheng , ZHANG, Lianshan , HUANG, Jian
IPC分类号： A61K31/438 , A61P1/08 , C07D471/10
摘要： The present disclosure relates to the use of an NK1 antagonist prodrug compound and a 5-HT3 receptor antagonist. In particular, the present disclosure relates to the use of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof in combination with a 5-HT3 receptor antagonist in the preparation of a drug for preventing or treating nausea and/or vomiting.
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4.发明公开
公开(公告)号：EP4289857A1
公开(公告)日：2023-12-13
申请号：EP22749058.8
申请日：2022-01-28
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , HONG, Min , TANG, Manping , SU, Lu , DENG, Mengdie , ZHANG, Jingyang , REN, Wenming , LIN, Kan , HUANG, Jian , LIAO, Cheng , ZHANG, Lianshan
摘要： A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.
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公开(公告)号：EP4403574A1
公开(公告)日：2024-07-24
申请号：EP22869313.1
申请日：2022-09-15
发明人： CAO, Zhiliang , WANG, Baohui , LIN, Yuan , LIN, Kan , LIAO, Cheng
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
CPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , A61P35/00
摘要： The present disclosure relates to a protein specifically binding to PD-1 and a pharmaceutical use thereof. Specifically, the present disclosure provides a protein specifically binding to PD-1, a protein specifically binding to PD-1/PVRIG/TIGIT, and a use thereof in the treatment of a disease (such as cancer).
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公开(公告)号：EP4365200A1
公开(公告)日：2024-05-08
申请号：EP22832015.6
申请日：2022-06-28
发明人： LIN, Yuan , SU, Lu , LIN, Kan , LIAO, Cheng
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： A61K39/395 , C07K16/28
摘要： Provided are an anti-CD40 antibody, an antigen-binding fragment and a medical use thereof, as well as a pharmaceutical composition containing the anti-CD40 antibody or antigen-binding fragment thereof, and a method for treating and preventing disease, in particular a method for treating autoimmune disease.
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公开(公告)号：EP4119162A1
公开(公告)日：2023-01-18
申请号：EP21768888.6
申请日：2021-03-12
发明人： LIN, Yuan , LIN, Kan , JIN, Xinsheng , ZHANG, Man , LIAO, Cheng
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K7/06 , C12N15/13 , G01N33/574
摘要： A PVRIG binding protein and its medical uses. Specifically, an anti-PVRIG single-domain antibody and an anti-PVRIG and -TIGIT bispecific antibody, pharmaceutical compositions comprising the antibodies, a method for treating cancer, and pharmaceutical uses.
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公开(公告)号：EP4393950A1
公开(公告)日：2024-07-03
申请号：EP22860540.8
申请日：2022-08-24
发明人： LIN, Yuan , CHEN, Simeng , WU, Tingting , HU, Rongting , LIAO, Cheng
摘要： An FAP/CD40 binding molecule and the medicinal use thereof. Specifically, provided are an FAP binding molecule, a CD40 binding molecule and an FAP/CD40 binding molecule, a method for preventing and treating diseases (such as tumors or cancers) using same, and the medicinal use thereof.
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公开(公告)号：EP4151655A1
公开(公告)日：2023-03-22
申请号：EP21804918.7
申请日：2021-05-14
发明人： CHEN, Simeng , ZHANG, Wei , JIANG, Fuwei , LIAO, Cheng
摘要： The present disclosure relates to anti-CD25 antibodies, antigen-binding fragments thereof, and medical uses thereof. Specifically, the present disclosure relates to anti-CD25 antibodies and their use for preparing anti-tumor drugs.
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公开(公告)号：EP4435002A1
公开(公告)日：2024-09-25
申请号：EP22897980.3
申请日：2022-11-29
发明人： WANG, Nan , YANG, Xiaofeng , ZHANG, Wei , CAO, Zhiliang , YE, Hao , SHEN, Yuhong , LIAO, Cheng
摘要： Provided are a modified immunoglobulin single variable domain, and a protein or polypeptide comprising same. The modified immunoglobulin single variable domain has reduced binding to a pre-anti-drug antibody. Specifically, the C terminal of the immunoglobulin single variable domain comprises amino acid modification. The present invention further relates to an immunoglobulin single variable domain, the pharmaceutical use of a protein or polypeptide comprising same, a pharmaceutical composition, an encoding nucleic acid, and a preparation method.
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