公开(公告)号：EP3875486A1

公开(公告)日：2021-09-08

申请号：EP19880700.0

申请日：2019-10-30

申请人： Joint Stock Company "Biocad"

发明人： IAKOVLEV, Pavel Andreevich ,  PESTOVA, Natalia Eugenievna ,  ANIKINA, Arina Vitalevna ,  TRUDOVISHNIKOVA, Anna Alexandrovna ,  SHCHEMELEVA, Mariia Aleksandrovna ,  KHARATIAN, Nina Grachyaevna ,  SOLOVYEV, Valery Vladimirovich ,  MISORIN, Alexey Konstantinovich ,  DIDUK, Sergei Vasilyevich ,  EROSHOVA, Anna Vladimirovna ,  USATOVA, Veronika Sergeevna ,  KRENDELEVA, Elena Andreevna ,  USTIUGOV, Iakov Iurevich ,  ALEKSANDROV, Aleksei Aleksandrovich ,  SMIRNOVA, Iana Andreevna ,  KOSKOVA, Svetlana Vladimirovna ,  IVANOV, Roman Alekseevich ,  MOROZOV, Dmitry Valentinovich

IPC分类号： C07K16/28 ,  C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12P21/08 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02

摘要： The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.

公开(公告)号：EP3486257A1

公开(公告)日：2019-05-22

申请号：EP17828049.1

申请日：2017-07-04

申请人： Joint Stock Company "Biocad"

发明人： EKIMOVA, Viktoriia Mikhailovna ,  KORZHAVIN, Dmitry Valeryevich ,  CHERNYKH, Yulia Sergeevna ,  NEMANKIN, Timofey Aleksandrovich ,  SOLOVYEV, Valery Vladimirovich ,  VLADIMIROVA, Anna Konstantinovna ,  BULANKINA, Irina Andreevna ,  DIDUK, Sergei Vasilyevich ,  EROSHOVA, Anna Vladimirovna ,  USTIUGOV, Iakov Iurevich ,  ARTIUKHOVA, Marina Vladimirovna ,  ULITIN, Andrei Borisovich ,  IVANOV, Roman Alekseevich ,  MOROZOV, Dmitry Valentinovich

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  A61K39/395

摘要： The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.