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公开(公告)号：EP3613770A2
公开(公告)日：2020-02-26
申请号：EP18786945.8
申请日：2018-04-11
发明人： ULITIN, Andrei Borisovich , EKIMOVA, Viktoriia Mikhailovna , SOFRONOVA, Ekaterina Vladimirovna , CHERNYKH, Yulia Sergeevna , AGEEV, Sergei Andreevich , VLADIMIROVA, Anna Konstantinovna , ALEKSANDROV, Aleksei Aleksandrovich , GREBNEV, Pavel Alekseevich , SOLOVYEV, Valery Vladimirovich , USTIUGOV, Iakov Iurevich , IAKOVLEV, Pavel Andreevich , NEMANKIN, Timofey Aleksandrovich , MOROZOV, Dmitry Valentinovich
摘要： The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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公开(公告)号：EP3964525A2
公开(公告)日：2022-03-09
申请号：EP20794288.9
申请日：2020-04-23
发明人： ULITIN, Andrei Borisovich , KOZLOVA, Olesya Nikolaevna , GORDEEV, Aleksandr Andreevich , BURNYSHEVA, Ksenia Mihailovna , ISHUTINOVA, Anastasia Nikolaevna , SOZONOVA, Aleksandra Aleksandrovna , AGEEV, Sergei Andreevich , DORONIN, Aleksandr Nikolaevich , TSYMPILOV, Vladimir Sergeevich , MITROSHIN, Ivan Vladimirovich , SOLOVYEV, Valery Vladimirovich , USTIUGOV, Iakov Iurevich , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
IPC分类号： C07K16/24 , C07K16/28 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/08 , A61K39/395 , A61P35/00
摘要： The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.
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公开(公告)号：EP3450456A1
公开(公告)日：2019-03-06
申请号：EP16900649.1
申请日：2016-12-02
发明人： MOROZOV, Dmitry Valentinovich , ULITIN, Andrei Borisovich , ZUBAREVA, Ekaterina Sergeevna , USTIUGOV, Iakov Iurevich , KARABELSKII, Aleksandr Vladimirovich , KORZHAVIN, Dmitry Valeryevich , CHERNOVSKAYA, Tatiana Veniaminovna , GRACHEV, Aleksandr Valerevich , BASOVSKIY, Yury Ivanovich , LOMKOVA, Ekaterina Aleksandrovna , USATOVA, Veronika Sergeevna , ALEKSANDROV, Aleksei Aleksandrovich , MOROZOVA, Elena Leonidovna , IVANOV, Roman Alekseevich , IAKOVLEV, Pavel Andreevich
摘要： The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
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公开(公告)号：EP3486257A1
公开(公告)日：2019-05-22
申请号：EP17828049.1
申请日：2017-07-04
发明人： EKIMOVA, Viktoriia Mikhailovna , KORZHAVIN, Dmitry Valeryevich , CHERNYKH, Yulia Sergeevna , NEMANKIN, Timofey Aleksandrovich , SOLOVYEV, Valery Vladimirovich , VLADIMIROVA, Anna Konstantinovna , BULANKINA, Irina Andreevna , DIDUK, Sergei Vasilyevich , EROSHOVA, Anna Vladimirovna , USTIUGOV, Iakov Iurevich , ARTIUKHOVA, Marina Vladimirovna , ULITIN, Andrei Borisovich , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , A61K39/395
摘要： The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.
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公开(公告)号：EP4370681A1
公开(公告)日：2024-05-22
申请号：EP22842553.4
申请日：2022-05-30
申请人： Joint Stock Company "Biocad" , Federal State Budgetary Scientific Institution Institute of Experimental Medicine
发明人： RUDENKO, Larisa Georgievna , ISAKOVA-SIVAK, Irina Nikolayevna , STEPANOVA, Ekaterina Alekseevna , MATIUSHENKO, Viktoriia Arkadienva , NISKANEN, Sergei Andreevich , NETEREBSKII, Bogdan Olegovich , VLADIMIROVA, Anna Konstantinovna , IAKOVLEV, Pavel Andreevich , USTIUGOV, Iakov Iurevich , SHEUDZHEN, Timur Mugdinovich , DORONIN, Aleksandr Nikolaevich , OSTROUKHOVA, Tatiana Urevna , ALEKSANDROV, Aleksei Aleksandrovich , MOROZOV, Dmitry Valentinovich
IPC分类号： C12N15/117 , C12N15/50 , A61P31/14 , A61P31/16 , C07K14/165 , A61K39/215 , A61P37/04
CPC分类号： A61P31/14 , A61P31/16 , A61P37/04 , C12N15/86 , C12N7/00 , C12N2770/2002220130101 , C12N2770/2003420130101 , C12N2760/1612120130101 , C12N2760/1614320130101 , C12N2760/1613420130101 , C12N2760/1612220130101 , C07K14/005 , A61K39/12 , A61K2039/7020130101 , A61K2039/525420130101 , A61K2039/54420130101 , A61K2039/5720130101
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公开(公告)号：EP3875486A1
公开(公告)日：2021-09-08
申请号：EP19880700.0
申请日：2019-10-30
发明人： IAKOVLEV, Pavel Andreevich , PESTOVA, Natalia Eugenievna , ANIKINA, Arina Vitalevna , TRUDOVISHNIKOVA, Anna Alexandrovna , SHCHEMELEVA, Mariia Aleksandrovna , KHARATIAN, Nina Grachyaevna , SOLOVYEV, Valery Vladimirovich , MISORIN, Alexey Konstantinovich , DIDUK, Sergei Vasilyevich , EROSHOVA, Anna Vladimirovna , USATOVA, Veronika Sergeevna , KRENDELEVA, Elena Andreevna , USTIUGOV, Iakov Iurevich , ALEKSANDROV, Aleksei Aleksandrovich , SMIRNOVA, Iana Andreevna , KOSKOVA, Svetlana Vladimirovna , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
IPC分类号： C07K16/28 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/08 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/02
摘要： The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.
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