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    Separation material for blood coagulation factor, preparation and use thereof
    8.
    发明公开
    Separation material for blood coagulation factor, preparation and use thereof 失效
    TrennungsmaterialfürBlutgerinnungsfaktoren，seine Herstellung und Verwendung。

    公开(公告)号：EP0434354A1

    公开(公告)日：1991-06-26

    申请号：EP90313814.7

    申请日：1990-12-18

    申请人： KURITA WATER INDUSTRIES LTD. ,  Yamamoto, Tetsuro ,  Motozato, Yoshiaki

    发明人： Wakita, Masaaki, c/o Kurita Water ,  Tomoda, Takashi, c/o Kurita Water ,  Yamaguchi, Masato, c/o Kurita Water ,  Joko, Isao, c/o Kurita Water ,  Morita, Hiroshi, c/o Kurita Water ,  Yamamoto, Tetsuro ,  Motozato, Yoshiaki

    IPC分类号： B01J20/22 ,  C07K3/18 ,  C07K13/00

    CPC分类号： C07K14/755 ,  B01J20/24 ,  B01J20/28019 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/3092 ,  B01J20/3212 ,  B01J20/3274 ,  B01J2220/4812 ,  B01J2220/58

    摘要： A separation material capable of realizing efficient separation and recovery of a blood coagulation factor, especially blood coagulation factor VIII or complex thereof with von Willebrand factor, from plasma or from samples containing blood coagulation factors.
    The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity to the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1. 5 m² per milliliter of the separation material with respect to pores having diameters of at least 0.1 µ m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5 X 10⁶ as determined with polyethylene glycol.
    The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5 X 10⁶ to an activation by l,l' -carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exihit after being linked as ligand on the porous particulate material an affinity to the blood coagulation factor to be recovered, so as to form a porous matrix having a specific surface area of at least 1.5 m² per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 µ m.

    摘要翻译： 能够从血浆或含有血液凝固因子的样品中实现血液凝固因子，特别是凝血因子VIII或其与血管性血友病因子复合物的有效分离和回收的分离物质。 用于分离和回收凝血因子的分离材料包括其上连接有一个或多个配体的多孔基质，每个配体由对待回收的凝血因子表现出亲和力的基团组成，所述基质的比表面积至少为1 相对于直径为至少0.1μm的孔的每毫升分离材料为5m 2，并且衍生自具有至少1.5×10 6的排阻极限分子量的多孔颗粒材料，所述多孔颗粒材料由 聚乙二醇。 分离材料通过以下步骤制备：使具有至少1.5×10 6排阻极限分子量的多孔颗粒材料通过1,1-羰基二咪唑烷化，甲磺酸化，碳二亚胺化，硫代丙基化，环氧化，溴化的活化 或使用相应的活化剂甲酰化，并使如此活化的多孔颗粒材料与在多孔颗粒材料上作为配体连接后出现的一种或多种物质对待回收的凝血因子具有亲和力，以形成具有 相对于直径至少为0.1μm的孔，每毫升多孔颗粒材料的比表面积至少为1.5m 2。