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    Separation material for blood coagulation factor, preparation and use thereof
    3.
    发明公开
    Separation material for blood coagulation factor, preparation and use thereof 失效
    TrennungsmaterialfürBlutgerinnungsfaktoren，seine Herstellung und Verwendung。

    公开(公告)号：EP0434354A1

    公开(公告)日：1991-06-26

    申请号：EP90313814.7

    申请日：1990-12-18

    申请人： KURITA WATER INDUSTRIES LTD. ,  Yamamoto, Tetsuro ,  Motozato, Yoshiaki

    发明人： Wakita, Masaaki, c/o Kurita Water ,  Tomoda, Takashi, c/o Kurita Water ,  Yamaguchi, Masato, c/o Kurita Water ,  Joko, Isao, c/o Kurita Water ,  Morita, Hiroshi, c/o Kurita Water ,  Yamamoto, Tetsuro ,  Motozato, Yoshiaki

    IPC分类号： B01J20/22 ,  C07K3/18 ,  C07K13/00

    CPC分类号： C07K14/755 ,  B01J20/24 ,  B01J20/28019 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/3092 ,  B01J20/3212 ,  B01J20/3274 ,  B01J2220/4812 ,  B01J2220/58

    摘要： A separation material capable of realizing efficient separation and recovery of a blood coagulation factor, especially blood coagulation factor VIII or complex thereof with von Willebrand factor, from plasma or from samples containing blood coagulation factors.
    The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity to the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1. 5 m² per milliliter of the separation material with respect to pores having diameters of at least 0.1 µ m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5 X 10⁶ as determined with polyethylene glycol.
    The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5 X 10⁶ to an activation by l,l' -carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exihit after being linked as ligand on the porous particulate material an affinity to the blood coagulation factor to be recovered, so as to form a porous matrix having a specific surface area of at least 1.5 m² per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 µ m.

    摘要翻译： 能够从血浆或含有血液凝固因子的样品中实现血液凝固因子，特别是凝血因子VIII或其与血管性血友病因子复合物的有效分离和回收的分离物质。 用于分离和回收凝血因子的分离材料包括其上连接有一个或多个配体的多孔基质，每个配体由对待回收的凝血因子表现出亲和力的基团组成，所述基质的比表面积至少为1 相对于直径为至少0.1μm的孔的每毫升分离材料为5m 2，并且衍生自具有至少1.5×10 6的排阻极限分子量的多孔颗粒材料，所述多孔颗粒材料由 聚乙二醇。 分离材料通过以下步骤制备：使具有至少1.5×10 6排阻极限分子量的多孔颗粒材料通过1,1-羰基二咪唑烷化，甲磺酸化，碳二亚胺化，硫代丙基化，环氧化，溴化的活化 或使用相应的活化剂甲酰化，并使如此活化的多孔颗粒材料与在多孔颗粒材料上作为配体连接后出现的一种或多种物质对待回收的凝血因子具有亲和力，以形成具有 相对于直径至少为0.1μm的孔，每毫升多孔颗粒材料的比表面积至少为1.5m 2。

    Beads of cross-linked glucomannan and production thereof
    7.
    发明公开
    Beads of cross-linked glucomannan and production thereof 失效
    Perlen von vernetzten Glukomannanen und ihre Herstellung。

    公开(公告)号：EP0298171A1

    公开(公告)日：1989-01-11

    申请号：EP87306092.5

    申请日：1987-07-10

    申请人： Motozato, Yoshiaki ,  Kurita Water Industries Ltd.

    发明人： Motozato, Yoshiaki

    IPC分类号： C08B37/14 ,  C08J9/26 ,  G01N30/48 ,  B01J20/22

    CPC分类号： C08J3/12 ,  B01J20/22 ,  B01J20/285 ,  B01J20/291 ,  C08B37/0087 ,  C08J2305/00

    摘要： Glucomannan beads which have a cross-linked structure, exhibit a degree of swelling of 1.5 to 15 ml of wet gel bed per g of dry gel, an exclusion limit molecular weight of 200 to 10⁸, and an average bead size of 1 to 500 µm.
    Such beads can be prepared by a process which comprises a process for the production of glucomannan beads having an average size of 1 to 500 µm and a cross-linked structure, which comprises suspending in an aqueous medium a solution containing 0.2 to 20% by weight of an ester of glucomannan, optionally together with a diluent, in a chlorinated hydrocarbon solvent which has a boiling point lower than that of the aqueous medium and which is immiscible or substantially immiscible with the aqueous medium; agitating the suspension, to cause the formation of droplets of the solution suspended in the aqueous medium; evaporating off the solvent contained in the liquid droplets, to leave spherical beads of the glucomannan ester; saponifying the beads of the glucomannan ester; and cross-linking the saponified beads by adding thereto a cross-linking agent in an amount of at least 0.5 part by weight per part by weight of the glucomannan beads.

    摘要翻译： 具有交联结构的葡甘露聚糖珠粒，每g干凝胶呈现1.5-15ml湿凝胶层的溶胀度，排阻极限分子量为200至10 8，平均珠粒度为1 至500亩。 这样的珠粒可以通过包括生产平均粒度为1〜500μm的葡甘露聚糖珠粒和交联结构体的方法制备，该方法包括在水性介质中悬浮含有0.2-20％的溶液 葡聚糖的酯，任选与稀释剂一起在氯化烃溶剂中，其沸点低于含水介质的沸点，并且与水介质不混溶或基本上不混溶; 搅拌悬浮液，使悬浮在水介质中的溶液的液滴形成; 蒸发液滴中含有的溶剂，留下葡萄糖聚糖酯的球形珠粒; 皂化葡甘露聚糖酯的珠粒; 并通过向其中加入至少0.5重量份的葡糖甘露聚糖珠的交联剂来交联皂化的珠粒。