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公开(公告)号：EP0212522A3
公开(公告)日：1987-07-15
申请号：EP86111064
申请日：1986-08-11
IPC分类号： G01N33/74 , G01N33/577 , G01N33/543
摘要： Described is an improved method for the measurement of TSH in blood or body liquid by immunoassays such as EIA and RIA, characterized in that TSH-P subunit specific monoclonal antibodies recognizing different epitopes are used. According to this method, TSH can easily be measured in high sensitivity with high specificity within a very short period of time without inhibition by the presence of other glycoprotein hormones such as LH, HCG and FSH. This method is useful for diagnosis of various diseases in which TSH plays a role, such as proto- phathic hypothyroidism, Basedow's disease and cretinism.
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2.发明公开Nonspecific-reaction inhibitor in an immunological assay with monoclonal antibody 无效用单克隆抗体进行免疫测定的非特异性反应抑制剂
公开(公告)号：EP0174026A3
公开(公告)日：1988-10-26
申请号：EP85111223
申请日：1985-09-05
发明人： Tsuji, Ichiroh , Unoki, Masanori , Aoyama, Noriaki
IPC分类号： G01N33/577 , C12N15/00
CPC分类号： G01N33/577 , G01N33/5306
摘要： Disclosed are certain animal sera and ascites that are useful for inhibiting the nonspecific-reactions occuring when carrying out an immunological assay with monoclonal antibodies (MCA). The use of the inhibitor makes the assay very accurate.
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公开(公告)号：EP0212522A2
公开(公告)日：1987-03-04
申请号：EP86111064.1
申请日：1986-08-11
IPC分类号： G01N33/74
摘要： Described is an improved method for the measurement of TSH in blood or body liquid by immunoassays such as EIA and RIA, characterized in that TSH-P subunit specific monoclonal antibodies recognizing different epitopes are used. According to this method, TSH can easily be measured in high sensitivity with high specificity within a very short period of time without inhibition by the presence of other glycoprotein hormones such as LH, HCG and FSH. This method is useful for diagnosis of various diseases in which TSH plays a role, such as proto- phathic hypothyroidism, Basedow's disease and cretinism.
摘要翻译： 描述了通过免疫测定如EIA和RIA测量血液或体液中的TSH的改进方法，其特征在于使用识别不同表位的TSH-β亚基特异性单克隆抗体。 根据该方法，可以在非常短的时间内容易地以高特异性的高灵敏度测定TSH，而不会抑制其它糖蛋白激素如LH，HCG和FSH的抑制。 这种方法可用于诊断TSH发挥作用的各种疾病，如原发性甲状腺功能减退症，基诺病和克氏病。
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公开(公告)号：EP0173341B1
公开(公告)日：1990-04-04
申请号：EP85110914.0
申请日：1985-08-29
IPC分类号： G01N33/74 , G01N33/76 , G01N33/78 , G01N33/577
CPC分类号： C07K16/26
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公开(公告)号：EP0173973A3
公开(公告)日：1988-08-10
申请号：EP85110915
申请日：1985-08-29
IPC分类号： G01N33/577 , G01N33/74 , C12P21/00 , C12R01/91
CPC分类号： G01N33/74
摘要： Described is a highly sensitive immunoassay method for determining the amounts of TSH contained in body fluids, in which an anti-β-subunit TSH monoclonal antibody having a specific association constant value is used.
摘要翻译： 描述了用于确定体液中含有的TSH的量的高度灵敏的免疫测定方法，其中使用具有特定关联常数值的抗β-亚基TSH单克隆抗体。
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6.发明公开Nonspecific-reaction inhibitor in an immunological assay with monoclonal antibody 无效使用单克隆抗体在免疫学测试非特异性反应抑制剂。
公开(公告)号：EP0174026A2
公开(公告)日：1986-03-12
申请号：EP85111223.5
申请日：1985-09-05
发明人： Tsuji, Ichiroh , Unoki, Masanori , Aoyama, Noriaki
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , G01N33/5306
摘要： Disclosed are certain animal sera and ascites that are useful for inhibiting the nonspecific-reactions occuring when carrying out an immunological assay with monoclonal antibodies (MCA). The use of the inhibitor makes the assay very accurate.
摘要翻译： 本发明公开了某些动物血清和腹水做是有用的用于抑制非特异性-反应存在的当用单克隆抗体（MCA）的免疫学测定进行。 使用抑制剂的使测定非常准确。
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7.发明授权Nonspecific-reaction inhibitor in an immunological assay with monoclonal antibody 无效单克隆抗体免疫测定中非特异性反应抑制剂
公开(公告)号：EP0174026B1
公开(公告)日：1992-02-19
申请号：EP85111223.5
申请日：1985-09-05
发明人： Tsuji, Ichiroh , Unoki, Masanori , Aoyama, Noriaki
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , G01N33/5306
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8.发明公开Method for the determination of thyroid-stimulating hormone 失效Verfahren zur Bestimmung des thyroid-stimulierenden Hormons。
公开(公告)号：EP0173973A2
公开(公告)日：1986-03-12
申请号：EP85110915.7
申请日：1985-08-29
IPC分类号： G01N33/577 , G01N33/74 , C12P21/00
CPC分类号： G01N33/74
摘要： Described is a highly sensitive immunoassay method for determining the amounts of TSH contained in body fluids, in which an anti-β-subunit TSH monoclonal antibody having a specific association constant value is used.
摘要翻译： 描述了用于确定体液中含有的TSH的量的高度灵敏的免疫测定方法，其中使用具有特定关联常数值的抗β-亚基TSH单克隆抗体。
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公开(公告)号：EP0173341A1
公开(公告)日：1986-03-05
申请号：EP85110914.0
申请日：1985-08-29
IPC分类号： G01N33/74 , G01N33/76 , G01N33/78 , G01N33/577
CPC分类号： C07K16/26
摘要： Described is an immunoassay method which makes it possible to determine the amounts of thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone and human choriogonadotropin with the substantially same degrees of sensitivities for all the hormones, in which there is used a monoclonal antibody derived from a hybridoma obtained using the spleen cells of an animal immunized with only one of the hormones or its a-subunit.
摘要翻译： 描述了一种免疫测定方法，其可以确定促甲状腺激素，促卵泡激素，黄体生成激素和人绒毛膜促性腺激素的量，其对于所有激素具有基本相同程度的敏感性，其中使用衍生的单克隆抗体 来自使用仅用一种激素或其α亚基免疫的动物的脾细胞获得的杂交瘤。
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