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1.发明授权METHOD OF DETECTING THROMBOSIS BY MEASURING VON WILLEBRAND FACTOR-CLEAVING PROTEASE 有权检测方法的血栓通过测量血管性血友病因子裂解酶
公开(公告)号：EP1712918B1
公开(公告)日：2012-06-20
申请号：EP04807583.2
申请日：2004-12-22
申请人： Mitsubishi Chemical Medience Corporation , Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
IPC分类号： G01N33/573
CPC分类号： G01N33/6893 , G01N2333/95 , G01N2800/222 , G01N2800/226 , G01N2800/32 , Y10S436/811 , Y10T436/106664
摘要： A method of detecting the level of thrombus formation tendency or thrombosis through determining of the quantity of von Willebrand factor splitting enzyme. There is further disclosed a kit for detecting the level of thrombus formation tendency or thrombosis, which kit includes an antibody capable of specific binding to von Willebrand factor splitting enzyme, or a fragment of the antibody. The provided detection method and detection kit excel in convenience, speed and specificity.
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2.发明授权ENZYME PRODUCING PLASMA PROTEIN FRAGMENT HAVING EFFECT OF INHIBITING CANCER METASTASIS AND PLASMA PROTEIN FRAGMENT FRAGMENTED BY THE ENZYME 有权血浆蛋白片段生成酶与癌症转移锁定和EFFECT THROUGH这种酶片段化血浆蛋白片段
公开(公告)号：EP1118660B1
公开(公告)日：2011-04-27
申请号：EP99970118.8
申请日：1999-09-29
发明人： MORIKAWA, Wataru , KAMINAKA, Kazuyoshi , TAKEMOTO, Sumiyo , MAEDA, Hiroaki , NOZAKI, Chikateru , MIYAMOTO, Seiji
CPC分类号： C12N9/6454 , A61K35/00 , C12N9/6435 , C12N9/6478 , C12Y304/21007
摘要： An aspartic acid enzyme having a high homology with a cathepsin D precursor, which is a protein starting at the N-terminal amino acid residue with LVRIPLHKFT and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins typified by plasminogen molecular species to give a plasma protein fragment having an effect of inhibiting cancer metastasis; the plasma protein fragment having an effect of inhibiting cancer metastasis which is prepared via the degradation with the above enzyme; a process for preparing the protein fragment having an effect of inhibiting cancer metastasis which comprises degrading a plasma protein with the above enzyme; and remedies against cancer metastasis which contain as the major ingredient the above enzyme or a fragmented plasma protein.
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3.发明公开ENZYME PRODUCING PLASMA PROTEIN FRAGMENT HAVING EFFECT OF INHIBITING CANCER METASTASIS AND PLASMA PROTEIN FRAGMENT FRAGMENTED BY THE ENZYME 有权血浆蛋白片段生成酶与癌症转移锁定和EFFECT THROUGH这种酶片段化血浆蛋白片段
公开(公告)号：EP1118660A1
公开(公告)日：2001-07-25
申请号：EP99970118.8
申请日：1999-09-29
发明人： MORIKAWA, Wataru , KAMINAKA, Kazuyoshi-Gadenkoto-Mizukidai , TAKEMOTO, Sumiyo , MAEDA, Hiroaki , NOZAKI, Chikateru , MIYAMOTO, Seiji
CPC分类号： C12N9/6454 , A61K35/00 , C12N9/6435 , C12N9/6478 , C12Y304/21007
摘要： An aspartic enzyme having a high homology with a cathepsin D precursor, which is a protein having the N-terminal amino acid sequence LVRIPLHKFT and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins, typically plasminogen, to produce plasma protein fragments having an inhibitory activity to metastasis and growth of cancer; the plasma protein fragments having an inhibitory activity to metastasis and growth of cancer which is prepared via the degradation with the above enzyme; a process for preparing the protein fragments which comprises degrading plasma proteins with the above enzyme; and a medicament for treating and preventing metastasis and growth of cancer which comprises as a major ingredient the above enzyme or the plasma protein fragments.
摘要翻译： 纤溶酶原具有带组织蛋白酶D的前体，所有这一切都为具有N-末端氨基酸序列LVRIPLHKFT和表示约45 kDa的分子量在非还原SDS电泳和可降解的血浆蛋白，通常的蛋白质的同源性高天冬氨酸酶， 以产生具有对抑制活性和转移的癌症生长血浆蛋白片段; 具有抑制活性和转移的癌症生长，其经由与上述的酶的降解下载的血浆蛋白片段的所有; 用于制备该方法包括用上述的酶降解的血浆蛋白的蛋白片段的方法; 及用于治疗和预防转移和癌症生长，其包含作为主要成分的上述酶或血浆蛋白片段的药物。
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