公开(公告)号：EP3242683A1

公开(公告)日：2017-11-15

申请号：EP16700220.3

申请日：2016-01-11

申请人： Mabimmune Diagnostics AG ,  Neurimmune Holding AG ,  The University of Zurich

发明人： BROKOPP, Chad ,  GRIMM, Jan ,  COMBALUZIER, Benoit ,  GOERANSON, Mareike ,  LOHMANN, Christine ,  HOERSTRUP, Simon ,  NITSCH, Roger

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K47/6871 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/485 ,  C12Y304/14005 ,  G01N33/573 ,  G01N33/57492 ,  G01N2333/948 ,  G01N2800/224 ,  G01N2800/226 ,  G01N2800/323 ,  G01N2800/52

摘要： Provided are novel human-derived antibodies specific for Fibroblast Activation Protein (FAP), preferably capable of selectively inhibiting the enzymatic activity of FAP, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with FAP are provided. Assays and kits related to antibodies specific for FAP are also disclosed. The novel anti-FAP antibodies can be used in pharmaceutical and diagnostic compositions for FAP-targeted immunotherapy and diagnostics.

公开(公告)号：EP3224623A1

公开(公告)日：2017-10-04

申请号：EP15797249.8

申请日：2015-11-12

申请人： Syddansk Universitet

发明人： ASTAKHOVA, Irina Kira

IPC分类号： G01N33/564 ,  G01N33/86 ,  G01N33/92

CPC分类号： G01N33/564 ,  G01N33/86 ,  G01N33/92 ,  G01N2333/974 ,  G01N2800/226

摘要： There is provided phospholipid-peptide or phospholipid-protein conjugates useful for identification of autoantibodies, and in particular autoantibodies directed towards phospholipids. There is further provided intermediates and methods for their preparation as well as synthesis of the phospholipid-peptide or phospholipid-protein conjugates.

摘要翻译： 提供了用于鉴定自身抗体的磷脂 - 肽或磷脂 - 蛋白质偶联物，特别是针对磷脂的自身抗体。 还提供了用于其制备的中间体和方法以及磷脂 - 肽或磷脂 - 蛋白质缀合物的合成。

公开(公告)号：EP2418942B1

公开(公告)日：2017-08-23

申请号：EP10765133.3

申请日：2010-04-14

申请人： Sanford-Burnham Medical Research Institute

发明人： PELLECCHIA, Maurizio

IPC分类号： A01N35/00 ,  C07C235/66 ,  A61K31/166

CPC分类号： G01N33/564 ,  C07C39/14 ,  C07C49/83 ,  C07C235/66 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D277/64 ,  C07D417/10 ,  C12Q1/6883 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N2800/042 ,  G01N2800/046 ,  G01N2800/065 ,  G01N2800/10 ,  G01N2800/101 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/105 ,  G01N2800/122 ,  G01N2800/127 ,  G01N2800/202 ,  G01N2800/205 ,  G01N2800/222 ,  G01N2800/226 ,  G01N2800/24 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/285 ,  G01N2800/32 ,  G01N2800/325 ,  G01N2800/328 ,  G01N2800/347 ,  G01N2800/52

公开(公告)号：EP2883060A4

公开(公告)日：2016-06-29

申请号：EP13829360

申请日：2013-08-13

申请人： OTAGO INNOVATION LTD

发明人： ESPINER ERIC ARNOLD ,  PRICKETT TIMOTHY CHARLES RAMSEY

IPC分类号： G01N33/68 ,  A61K39/00 ,  C07K16/22

CPC分类号： G01N33/6893 ,  C07K16/22 ,  G01N33/74 ,  G01N2333/4703 ,  G01N2333/58 ,  G01N2800/226 ,  G01N2800/32 ,  G01N2800/52

摘要： The present disclosure relates to methods for the prognosis and/or diagnosis of vascular-related disorders in a subject and in particular pregnancy-related vascular disorders. The present disclosure is based on the finding that a positive correlation exists between positive prediction of a vascular disorder event in a subject and the concentration of the circulating marker NTproCNP (also referred to as NT-CNP) in humans and animals. In addition, the present disclosure is based on the finding that there is also a positive correlation between the occurrence of a vascular related adverse event during pregnancy and the concentration of the circulating marker NT-proCNP in the maternal circulation.

公开(公告)号：EP3028052A1

公开(公告)日：2016-06-08

申请号：EP14748175.8

申请日：2014-08-01

申请人： Fundación Pública Andaluza Progreso Y Salud ,  Instituto de Salud Carlos III

发明人： SORIA ESCOMS, Bernat ,  HMADCHA, Abdelkrim ,  ACOSTA LÓPEZ, Lourdes ,  ESCACENA ACOSTA, Natalia

IPC分类号： G01N33/86 ,  C12N5/00

CPC分类号： G01N33/6893 ,  A61K35/28 ,  C12N5/0667 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  F23J15/04 ,  F23J15/06 ,  F23J2215/50 ,  G01N33/86 ,  G01N2333/8132 ,  G01N2333/9726 ,  G01N2800/226 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/7095

摘要： The present invention refers to the use of tissue type plasminogen activator (tPA) and/or plasminogen activator inhibitor (PAI-1 ) for prognosticating or predicting a thrombotic event associated to the treatment with MSCs of a human subject suffering from an inflammatory disease.

摘要翻译： 本发明涉及一种用于观测与或相关联的预测与来自炎性疾病的人受治疗者的MSC治疗血栓形成事件中使用的组织型纤溶酶原激活剂（tPA）和/或纤溶酶原激活物抑制剂（PAI-1）的。

公开(公告)号：EP2997352A2

公开(公告)日：2016-03-23

申请号：EP14762263.3

申请日：2014-03-14

申请人： Bayer Healthcare LLC

发明人： JIN, Ye ,  MURPHY, John ,  HERMISTON, Terry

IPC分类号： G01N21/64

CPC分类号： G01N33/6893 ,  G01N33/56972 ,  G01N2333/964 ,  G01N2800/065 ,  G01N2800/085 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/226 ,  G01N2800/26 ,  G01N2800/368 ,  G01N2800/7095

摘要： Provided herein are protein biomarkers for NETosis related diseases, including proteases. Also provided are substrate sequences of such proteases and uses thereof.

公开(公告)号：EP2995957A2

公开(公告)日：2016-03-16

申请号：EP15176660.7

申请日：2008-09-10

申请人： Universiteit Leiden ,  Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center

发明人： BIESSEN, Ericus Anna Leonardus ,  VAN BERKEL, Theodorus Josephus Cornelis ,  KRAAIJEVELD, Adrian Otto

IPC分类号： G01N33/68 ,  A61P9/00

CPC分类号： G01N33/6863 ,  C07K14/523 ,  C07K16/24 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/53 ,  G01N2333/521 ,  G01N2333/523 ,  G01N2500/10 ,  G01N2800/226 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/50 ,  G01N2800/52 ,  H01J49/0027 ,  H01J49/164 ,  H01J49/40

摘要： The present invention relates to the identification of chemokine biomarkers predictive of future acute coronary syndromes including unstable angina pectoris (UAP). The present invention also identifies particular chemokines as potential therapeutic targets for intervention in cardiovascular diseases.

摘要翻译： 本发明涉及预测未来急性冠状动脉综合征（包括不稳定型心绞痛（UAP））的趋化因子生物标志物的鉴定。 本发明还鉴定了特定的趋化因子作为干预心血管疾病的潜在治疗靶点。

公开(公告)号：EP2856172A4

公开(公告)日：2016-03-02

申请号：EP13793724

申请日：2013-05-23

申请人： UNIV VERMONT

发明人： SCHNEIDER DAVID

IPC分类号： G01N33/68 ,  G01N33/48 ,  G01N33/53 ,  G01N33/96

CPC分类号： G01N33/56966 ,  A61K31/4365 ,  A61K31/443 ,  A61K31/519 ,  G01N33/6854 ,  G01N33/86 ,  G01N2333/70535 ,  G01N2800/222 ,  G01N2800/226 ,  G01N2800/52

摘要： Compositions and methods are provided for determining platelet reactivity where the levels of FcγRIIa on the surface of platelets is measured and if the levels of FcγRIIa are greater than a reference value, the platelets have enhanced reactivity.

摘要翻译： 提供了用于确定血小板反应性的组合物和方法，其中测量血小板表面上的FcγRIIa水平，如果FcγRIIa的水平大于参考值，则血小板具有增强的反应性。

公开(公告)号：EP2482078B1

公开(公告)日：2016-02-03

申请号：EP12152464.9

申请日：2007-05-01

申请人： Critical Care Diagnostics, Inc.

发明人： Snider, James V. ,  Jacobson, Sven

IPC分类号： G01N33/68

CPC分类号： G01N33/6869 ,  G01N33/6893 ,  G01N2333/7155 ,  G01N2800/226 ,  G01N2800/32 ,  G01N2800/325 ,  G01N2800/52

公开(公告)号：EP2732046A4

公开(公告)日：2015-03-25

申请号：EP12812054

申请日：2012-07-13

申请人： T2 BIOSYSTEMS INC

发明人： LOWERY THOMAS JAY ,  PAPKOV VYACHESLAV ,  MASSEFSKI WALTER W ,  DHANDA RAHUL ,  THAYER EDWARD CHRIS

IPC分类号： C12Q1/56

CPC分类号： G01N33/86 ,  A61B5/02007 ,  A61B5/0263 ,  A61B5/7246 ,  A61M1/10 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2230/20 ,  A61M2230/207 ,  G01N24/08 ,  G01N24/088 ,  G01N2800/226 ,  G01N2800/52 ,  G01R33/448 ,  Y02A90/26

摘要： The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.