公开(公告)号：EP2035377A1

公开(公告)日：2009-03-18

申请号：EP07725521.4

申请日：2007-05-24

申请人： KARO BIO AB

发明人： GARCIA COLLAZO, Ana Maria ,  KOCH, Eva, Kristina ,  MALM, Lars, Johan ,  CHENG, Aiping ,  HANSSON, Tomas, Fredrik

IPC分类号： C07D209/08 ,  C07D209/18 ,  C07D209/20 ,  C07D405/04 ,  C07D413/04 ,  A61P5/14 ,  A61K31/404

CPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/42 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04

摘要： The invention provides compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, (I) wherein R1, R2, R3, R4, R5, R6, Y and W are as defined in the specification. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist.

公开(公告)号：EP1537073B1

公开(公告)日：2007-09-12

申请号：EP03763744.4

申请日：2003-07-08

申请人： KARO BIO AB ,  Bristol-Myers Squibb Company

发明人： GARG, Neeraj ,  GADIM, Mahmoud, Rahimi ,  NORIN, Thomas, Anders, Wilson ,  MALM, Lars, Johan ,  RYONO, Denis, Evan

IPC分类号： C07C235/52 ,  C07C235/34 ,  A61K31/195 ,  A61P5/16

CPC分类号： C07C235/52 ,  C07C235/34

公开(公告)号：EP1537073A2

公开(公告)日：2005-06-08

申请号：EP03763744.4

申请日：2003-07-08

申请人： KARO BIO AB ,  BRISTOL-MYERS SQUIBB COMPANY

发明人： GARG, Neeraj ,  GADIM, Mahmoud, Rahimi ,  ERICSSON, Thomas, Anders, Wilson ,  MALM, Lars, Johan ,  RYONO, Denis, Evan

IPC分类号： C07C235/52 ,  C07C235/34 ,  A61K31/195 ,  A61P5/16

CPC分类号： C07C235/52 ,  C07C235/34

摘要： This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described herein is administered in a therapeutically effective amount.