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1.发明公开NITROGENOUS FUSED-RING DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE DERIVATIVES, AND USE THEREOF AS DRUGS 有权与含氮稠环，医药组合物衍生品在内，及其作为药物的衍生物
公开(公告)号：EP1724278A4
公开(公告)日：2012-05-02
申请号：EP05720416
申请日：2005-03-03
发明人： FUSHIMI NOBUHIKO , TERANISHI HIROTAKA , SHIMIZU KAZUO , YONEKUBO SHIGERU , ITO FUMIAKI , ISAJI MASAYUKI
IPC分类号： C07H17/02 , A61K31/7056 , A61K31/706 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P19/06 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00
CPC分类号： A61K31/7056 , A61K31/706 , C07H17/02
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2.发明公开FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF 有权稠合杂环衍生物，组合物容纳医疗及其医学用途
公开(公告)号：EP1609798A4
公开(公告)日：2009-06-17
申请号：EP04722965
申请日：2004-03-24
发明人： FUSHIMI NOBUHIKO , YONEKUBO SHIGERU , MURANAKA HIDEYUKI , SHIOHARA HIROAKI , TERANISHI HIROTAKA , SHIMIZU KAZUO , ITO FUMIAKI , ISAJI MASAYUKI
IPC分类号： A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7056 , A61K31/706 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P19/06 , A61P43/00 , C07H15/203 , C07H17/00 , C07H17/02 , C07H17/04
CPC分类号： C07H15/203 , C07H17/00 , C07H17/02 , C07H17/04
摘要： A fused heterocyclic derivative represented by the general formula (I) (wherein R is hydrogen, OH, etc.; R is hydrogen, halogeno, or alkyl; R and R each is hydrogen, OH, halogeno, etc.; Q is alkylene, etc.; ring A is aryl or heteroaryl; and G is the group represented by the formula (G1) or (G2)), (G1) (G2) a pharmacologically acceptable salt of the derivative, or a prodrug of either. They have excellent inhibitory activity against human SGLT and are useful as preventive or therapeutic agents for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity.
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3.发明公开GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE THEREFOR 审中-公开Glucopyranosyloxypyrazole衍生物组成容纳医疗，它的医疗使用和生产及其中间体
公开(公告)号：EP1400529A4
公开(公告)日：2007-12-19
申请号：EP02730718
申请日：2002-05-27
IPC分类号： A61P3/04 , A61P3/10 , A61P43/00 , C07D231/20 , C07H15/26 , C07H17/02 , A61K31/7056
CPC分类号： C07D231/20 , C07H15/26 , C07H17/02
摘要： A glucopyranosyloxypyrazole derivative represented by the following general formula (I), a pharmaceutically acceptable salt of the derivative, or a prodrug of either. (I) The compound has excellent inhibitory activity against human SGLT1 and is useful as a preventive or remedy for diseases attributable to hyperglycemia such as diabetes, complications of diabetes, and obesity. Also provided are a medicinal composition containing the derivative, salt, or prodrug; a medicinal use thereof; and an intermediate for the derivative. (In the general formula (I), R1 is hydrogen, etc.; one of Q and T is the group represented by (II) and the other is optionally substituted alkyl, etc.; and R2 is halogeno, etc.)
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