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11 条记录 (耗时 0.012 秒)

    Benzopyrans, their production and pharmaceutical compositions containing them
    5.
    发明公开
    Benzopyrans, their production and pharmaceutical compositions containing them 失效
    Benzopyrane，ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen。

    公开(公告)号：EP0042299A1

    公开(公告)日：1981-12-23

    申请号：EP81302700.0

    申请日：1981-06-16

    申请人： KOWA COMPANY, LTD.

    发明人： Shiratsuchi, Masami ,  Shimizu, Noboru ,  Shigyo, Hiromichi ,  Kyotani, Yoshinori ,  Kunieda, Hisashi ,  Kawamura, Kiyoshi ,  Sato, Seiichi ,  Akashi, Toshihiro ,  Nagakura, Masahiko ,  Sawada, Naotoshi ,  Uchida, Yasumi

    IPC分类号： C07D311/64 ,  C07D311/66 ,  C07D311/22 ,  C07D311/58 ,  A61K31/35

    CPC分类号： C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  Y10S514/821

    摘要： Benzopyrans represented by the formula
    wherein A represents a direct bond or -CH 2 O-

    R 1 represents a C 3 -C 5 alkyl group, a hydroxy-(C 3 -C 5 alkyl) group, a lower alkyl-amino-lower alkyl group, a ni- trato-(C 3 -C 5 alkyl) group or a phenyl-(C 1 -C 5 ) alkyl group where the phenyl may be substituted by a lower alkoxy group, R 2 represents hydrogen, halogen, OH, N0 2 , a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R 3 represents hydrogen or N0 2 , B represents a direct bond, a C 1 -C 7 alkylene group, a -O-lower alkylene group or a -CONH-lower alkylene group, and
    n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

    摘要翻译： 苯并吡喃由下式表示：其中A表示直接键或-CH 2 O-，R 1表示C 3 -C 5烷基，羟基 - （C 3 -C 5烷基），低级烷基 - 氨基 - 低级烷基 ，硝基 - （C 3 -C 5烷基）基或苯基 - （C 1 -C 5）烷基，其中苯基可以被低级烷氧基取代，R 2表示氢，卤素，OH，NO 2，氨基甲酰基，低级 烷基，低级烷氧基，低级亚烷基氧基或乙酰基，R 3表示氢或NO 2，B表示直接键，C 1 -C 7亚烷基，-O-低级亚烷基或-CONH-低级亚烷基 组，... n表示1或2; 并且它们的酸加成盐可用于例如降低心跳率，心肌耗氧量和血压。

    Benzoylpiperazine esters and a process for their production
    10.
    发明公开
    Benzoylpiperazine esters and a process for their production 失效
    苯甲酰基哌嗪酮和维他芬

    公开(公告)号：EP0098713A2

    公开(公告)日：1984-01-18

    申请号：EP83303583.5

    申请日：1983-06-22

    申请人： KOWA COMPANY, LTD.

    发明人： Fujii, Setsuo ,  Hattori, Eizuo ,  Hirata, Mitsuteru ,  Watanabe, Koichiro ,  Onogi, Kazuhiro ,  Nagakura, Masahiko

    IPC分类号： C07D295/18 ,  C07D215/48 ,  C07D217/26 ,  C07D237/26 ,  C07D241/44 ,  C07D249/08 ,  C07D261/10 ,  C07D307/80 ,  C07D307/84 ,  C07D311/04 ,  A61K31/495

    CPC分类号： C07D209/48 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D217/26 ,  C07D237/28 ,  C07D241/44 ,  C07D261/18 ,  C07D295/192 ,  C07D307/79 ,  C07D307/84 ,  C07D307/86 ,  C07D311/12 ,  C07D311/58 ,  C07D311/84 ,  C07D317/68 ,  C07D319/18 ,  C07D333/54 ,  C07D333/60

    摘要： Benzoylpiperazine esters and acid addition salts thereof are disclosed, which esters have the following formula:
    wherein A represents a single bond or an alkylene group, vinylene group, -O-alkylene group or methine group, R 1 represents a bicyclic carbon ring residue which may be substituted with a lower alkyl group, lower alkoxy group, oxo group or nitro group or a halogen atom, or may be partially saturated; a fluorene residue which may contain an oxo group; a fluorenylidene group; an anthracene residue; a phenathrene residue which may be substituted with a lower alkyl group, or may be partially saturated; a benzofuran residue or thianaphthene residue which may be substituted with a lower alkyl group or lower alkoxy group; a benzopyran residue or benzoazine residue which may be substituted with an oxo group or phenyl group and partially saturated; a phthalimide residue; a benzodiazine residue; an isooxazole residue which may be substituted with a lower alkyl group or phenyl group; or an alkylene dioxybenzene residue or xanthene residue; and R 2 represents an alkyl group, cycloalkyl group, cycloalkylalkyl group or aralkyl group; except the case where A is a single bond, R l is
    and R 2 is a methyl group. The esters exhibit excellent chymotrypsin inhibitive activity.

    摘要翻译： 公开了苯甲酰哌嗪酯及其酸加成盐，该酯具有下式：其中A表示单键或亚烷基，亚乙烯基，-O-亚烷基或次甲基，R 1表示双环碳 可以被低级烷基，低级烷氧基，氧代基或硝基或卤素原子取代的环状残基，或者可以是部分饱和的; 可含有氧代基的芴残基; 亚芴基; 蒽残基; 可以被低级烷基取代的或可以部分饱和的苯硫醇残基; 可以被低级烷基或低级烷氧基取代的苯并呋喃残基或硫杂残基; 可以被氧代基或苯基取代并部分饱和的苯并吡喃残基或苯并嗪残基; 邻苯二甲酰亚胺残基; 苯并二氮残基; 可以被低级烷基或苯基取代的异恶唑残基; 或亚烷基二氧基苯残基或呫吨残基; R2代表烷基，环烷基，环烷基烷基或芳烷基; 除了A是单键的情况，R1是... ...，R2是甲基。 该酯表现出优异的糜蛋白酶抑制活性。