公开(公告)号：EP1731495A4

公开(公告)日：2008-03-26

申请号：EP05727496

申请日：2005-03-25

申请人： KURARAY CO ,  DAIICHI SEIYAKU CO

发明人： KOYAKUMARU KENICHI ,  UEYAMA SHINGO ,  UJITA KATSUJI ,  HAYASHIBARA TATSUHIKO ,  NAKAGAWA NAOSHI ,  AKIBA TOSHIFUMI ,  SAITO TATSURU

IPC分类号： C07C45/65 ,  C07C45/59 ,  C07C45/70 ,  C07C47/277 ,  C07C47/37

CPC分类号： C07C45/59 ,  C07C45/65 ,  C07C45/70 ,  C07C47/277 ,  C07C47/37 ,  C07C2601/02

摘要： A process for industrially advantageously and easily producing a cyclopropane monoacetal derivative represented by the general formula (III) through a small number of steps, characterized by reacting a halogenated unsaturated carbonyl compound represented by the general formula (II) with an alcoholate. (In the formulae, the symbols are the same as defined in the description.)

摘要翻译： 通过少量步骤在工业上有利和容易地生产通式（III）表示的环丙烷单缩醛衍生物的方法，其特征在于使由通式（II）表示的卤代不饱和羰基化合物与醇盐反应。 （在公式中，符号与描述中定义的符号相同。）

公开(公告)号：EP1731494A4

公开(公告)日：2008-03-26

申请号：EP05727497

申请日：2005-03-25

申请人： KURARAY CO ,  DAIICHI SEIYAKU CO

发明人： KOYAKUMARU KENICHI ,  HAYASHIBARA TATSUHIKO ,  AKIBA TOSHIFUMI ,  SAITO TATSURU

IPC分类号： C07C45/59 ,  C07C45/60 ,  C07C47/277

CPC分类号： C07C47/277 ,  C07C45/59 ,  C07C45/60

摘要： Disclosed is a method for producing a halogenated unsaturated carbonyl compound commercially advantageously without causing environmental problems. A method for producing a halogenated unsaturated carbonyl compound represented by the general formula (III) below is characterized in that an alkoxy cyclic ether represented by the general formula (I) below is reacted with an acid halide represented by the general formula (II) below. (In the above formulae, symbols are as defined in the description.)

公开(公告)号：EP1258478A4

公开(公告)日：2006-03-15

申请号：EP01906267

申请日：2001-02-23

申请人： DAIICHI SEIYAKU CO

发明人： SAITO TATSURU ,  JOUNO TOSHIAKI ,  TANI YU-ICHIRO ,  AKIBA TOSHIFUMI

IPC分类号： A01N43/42 ,  A61K31/47 ,  A61K31/4709 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04

CPC分类号： C07D215/56 ,  A01N43/42 ,  A61K31/47 ,  A61K31/4709 ,  C07D401/04

摘要： A process for efficiently producing artificial quinolonecarboxylic acid-type antimicrobials which are expected as excellent drugs and pesticides and intermediates compounds to be used therein. According to this process, an amine substituent, which is a substituent at the 7-position of quinolonecarboxylic acid derivatives, can be efficiently introduced.

公开(公告)号：EP1310487A4

公开(公告)日：2004-03-03

申请号：EP01954496

申请日：2001-08-07

申请人： DAIICHI SEIYAKU CO

发明人： NAKAYAMA KEIJI ,  MUTO MAKOTO ,  SAITO TATSURU ,  TANI YUICHIRO ,  AKIBA TOSHIFUMI

IPC分类号： C07D209/54 ,  C07C45/64 ,  C07C45/38 ,  C07C47/293 ,  C07C47/37 ,  C07C209/48 ,  C07C211/18 ,  C07C253/16 ,  C07C255/31

CPC分类号： C07D209/54

摘要： Processes for preparing intermediate compounds (VII) and compounds (VIII) and (XIV), which are useful as raw materials in the synthesis of antimicrobial compounds, from compounds (I) or (X) trough compounds (II); and novel compounds useful in the processes.

公开(公告)号：EP0829473A4

公开(公告)日：1998-10-07

申请号：EP96914415

申请日：1996-05-23

申请人： DAIICHI SEIYAKU CO

发明人： AKIBA TOSHIFUMI ,  EBATA TUTOMU ,  SAITO TATSURU ,  SHIMIZU SADAHIRO ,  HIRAI KEIICHI ,  OHTA NAOKI ,  TOJO TOSHIAKI

IPC分类号： C07C255/31 ,  C07C271/22 ,  C07D209/54 ,  C07C253/30 ,  C07C255/28 ,  C07M7/00

CPC分类号： C07C271/22 ,  C07C255/31 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/54

摘要： Compounds of general formula (I), wherein n is an integer of 2 to 5; R1 is H or a substituent of general formula (R1) (wherein R?a, Rb and Rc¿ are each phenyl, phenylmethyl or naphthyl optionally substituted with one or more substituents of at least one member selected from the group consisting of C¿1?-C4 alkyl, C1-C4 alkoxy, halogeno and nitro, H or C1-C4 alkyl); and R?2¿ is H or C¿1?-C4 alkyl (with the proviso that the compound wherein n is 2, R?1¿ is H and R2 is ethyl is excepted); other compounds of general formula (II) prepared from the compounds of general formula (I), being useful as an antimicrobial; and novel processes for preparing these compounds at a low cost and in less steps.

摘要翻译： 通式（I）的化合物，其中n是2至5的整数; R 1是H或通式（R 1）的取代基（其中R 3a，R b和R c各自是苯基，苯基甲基或萘基，其任选被一个或多个选自C 1 C 1 -C 4烷基，C 1 -C 4烷氧基，卤代和硝基，H或C 1 -C 4烷基）; R 2'是H或C 1 -C 4烷基（条件是其中n是2，R 1'是H并且R 2是乙基的化合物是例外）。 由通式（I）化合物制备的通式（II）的其它化合物可用作抗微生物剂; 以及以较低成本和较少步骤制备这些化合物的新方法。