公开(公告)号：EP1310487A4

公开(公告)日：2004-03-03

申请号：EP01954496

申请日：2001-08-07

申请人： DAIICHI SEIYAKU CO

发明人： NAKAYAMA KEIJI ,  MUTO MAKOTO ,  SAITO TATSURU ,  TANI YUICHIRO ,  AKIBA TOSHIFUMI

IPC分类号： C07D209/54 ,  C07C45/64 ,  C07C45/38 ,  C07C47/293 ,  C07C47/37 ,  C07C209/48 ,  C07C211/18 ,  C07C253/16 ,  C07C255/31

CPC分类号： C07D209/54

摘要： Processes for preparing intermediate compounds (VII) and compounds (VIII) and (XIV), which are useful as raw materials in the synthesis of antimicrobial compounds, from compounds (I) or (X) trough compounds (II); and novel compounds useful in the processes.

公开(公告)号：EP1582513A4

公开(公告)日：2006-07-05

申请号：EP04700528

申请日：2004-01-07

申请人： DAIICHI SEIYAKU CO

发明人： TANI YUICHIRO ,  NAKAYAMA KEIJI ,  SAKURATANI KENJI ,  SATO KOJI

IPC分类号： C07C67/317 ,  C07B61/00 ,  C07C69/74

CPC分类号： C07C67/317 ,  C07C2601/02 ,  C07C69/74

摘要： A process for production of 2-fluorocyclopropane-1 -carboxylic esters, characterized by reacting a compound represented by the general formula (1) with a reducing agent in the presence of a phase transfer catalyst: (1) [wherein X is chloro, bromo, or iodo; and R1 is alkyl having 1 to 8 carbon atoms, aryl having 6 to 12 carbon atoms, alkenyl having 2 to 8 carbon atoms, or aralkyl composed of aryl having 6 to 12 carbon atoms and alkylene having 1 to 6 carbon atoms]. According to the process, the reaction time of dehalogenation can be remarkably shortened.

摘要翻译： 一种制备2-氟环丙烷-1-羧酸酯的方法，其特征在于在相转移催化剂存在下使通式（1）代表的化合物与还原剂反应：（1）[其中X是氯，溴 ，或碘; 和R1是具有1-8个碳原子的烷基，具有6-12个碳原子的芳基，具有2-8个碳原子的链烯基或由具有6-12个碳原子的芳基和具有1-6个碳原子的亚烷基构成的芳烷基。 根据该过程，脱卤的反应时间可以显着缩短。

公开(公告)号：EP1211254A4

公开(公告)日：2006-05-03

申请号：EP00957001

申请日：2000-09-07

申请人： DAIICHI SEIYAKU CO

发明人： SATO KOUJI ,  TAKAYANAGI YOSHIHIRO ,  OKANO KATSUHIKO ,  NAKAYAMA KEIJI ,  IMURA AKIHIRO ,  ITOH MIKIHIRO ,  YAGI TSUTOMU ,  KOBAYASHI YUKINARI ,  NAGAI TOMOYUKI

IPC分类号： A61P31/04 ,  C07C213/00 ,  C07C215/16 ,  C07C227/08 ,  C07C227/34 ,  C07C227/36 ,  C07C229/18 ,  C07C229/30 ,  C07D265/36 ,  C07D498/06 ,  C12P13/00 ,  A61K31/5383 ,  C07C227/06

CPC分类号： C07D498/06 ,  C07B57/00 ,  C07B2200/07 ,  C07C213/00 ,  C07C227/08 ,  C07C227/34 ,  C07C227/36 ,  C07C229/18 ,  C07C229/30 ,  C07D265/36 ,  C12P13/001 ,  C12P13/02 ,  C12P13/04 ,  C12P41/005 ,  Y02P20/55 ,  C07C215/16

摘要： The invention provides an industrially advantageous process for the preparation of antimicrobial drugs and industrially advantageous processes for the preparation of intermediates of antimicrobial drugs. Specifically, a process for preparing compounds (VI-a) according to the following reaction scheme; and intermediates therefor: (A)