公开(公告)号：EP1213287A4

公开(公告)日：2002-09-18

申请号：EP00953475

申请日：2000-08-18

申请人： KYORIN SEIYAKU KK

发明人： MIYACHI HIROYUKI ,  NOMURA MASAHIRO ,  TANASE TAKAHIRO ,  MURAKAMI KOJI ,  TSUNODA MASAKI

IPC分类号： A61P3/06 ,  A61P3/10 ,  A61P43/00 ,  C07D277/34 ,  A61K31/426

CPC分类号： C07D277/34

摘要： Novel benzylthiazolidine-2,4-dione derivatives which bind as ligands to human peroxisome proliferator-activated receptor (PPAR) to thereby activate the receptor and exert antihyperglycemic and antihyperlipidemic effects; and a process for the preparation thereof. Specifically, substituted benzylthiazolidine-2,4-dione derivatives represented by general formula (1), pharmaceutically acceptable salts thereof, or hydrates of both; and a process for the preparation of them: wherein A is -CH2CONH-, -NHCONH-, -CH2CH2CO-, or -NHCOCH2-; B is C1-C4 lower alkyl, C1-C3 lower alkoxy, halogeno, trifluoromethyl, trifluoromethoxy, substituted or unsubstituted phenyl, substituted or unsubstituted phenoxy, or substituted or unsubstituted benzyloxy.

公开(公告)号：EP1431275A4

公开(公告)日：2006-05-31

申请号：EP02768056

申请日：2002-09-25

申请人： KYORIN SEIYAKU KK

发明人： KOHNO YASUSHI ,  ANDO NAOKI ,  TANASE TAKAHIRO ,  KURIYAMA KAZUHIKO ,  IWANAMI SATORU ,  KUDOU SHINJI

IPC分类号： A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/16 ,  A61P27/14 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  C07C217/64 ,  C07D319/06 ,  C07C217/34 ,  A61K31/137 ,  A61K31/138 ,  A61K31/277 ,  A61K31/4409 ,  C07C217/56 ,  C07C255/54 ,  C07C317/22 ,  C07C323/20 ,  C07D213/30

CPC分类号： C07D319/06 ,  C07C217/64

摘要： A diaryl ether derivative having excellent immunosuppressive activity and reduced in side effects. The diaryl ether derivative is represented by the general formula (1): (1) {e.g., 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]propyl-1,3-propanediol}.

公开(公告)号：EP2647620A4

公开(公告)日：2014-04-30

申请号：EP11845569

申请日：2011-11-30

申请人： KYORIN SEIYAKU KK

发明人： TSUBUKI TAKESHI ,  TANASE TAKAHIRO ,  SUZUKI MASASHI

IPC分类号： C07C229/64 ,  C07C227/16 ,  C07C227/18 ,  C07D413/04

CPC分类号： C07C229/64 ,  C07C227/18 ,  C07D413/04

公开(公告)号：EP1285908A4

公开(公告)日：2005-09-21

申请号：EP01932262

申请日：2001-05-25

申请人： KYORIN SEIYAKU KK

发明人： MIYACHI HIROYUKI ,  NOMURA MASAHIRO ,  TAKAHASHI YUKIE ,  TANASE TAKAHIRO ,  MURAKAMI KOUJI ,  SUZUKI MASAHIRO

IPC分类号： A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C59/68 ,  C07C69/734 ,  C07C69/738 ,  C07C229/34 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C251/48 ,  C07C323/56 ,  A61K31/192 ,  C07C233/81 ,  C07C235/44 ,  C07C235/78

CPC分类号： C07C59/68 ,  C07C69/734 ,  C07C69/738 ,  C07C229/34 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C251/48 ,  C07C323/56

摘要： Novel substituted phenylpropionic acid derivatives of the general formula (1), which bind to human peroxisome proliferator activated receptor alpha (PPAR alpha ) as ligand to activate the receptor and thereby exhibit a potent lipid-decreasing effect; and use thereof as drugs: (1) wherein R is lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted benzyloxy; R is hydrogen, lower alkyl, or lower alkoxy; R is lower alkoxy; and A is -CH2CONH-, -NHCOCH2-, -CH2CH2CO-, CH2CH2CH2-, -CH2CH2O-, -CONHCH2-, -CH2NHCH2-, -COCH2O-, -OCH2CO-, -COCH2NH-, or NHCH2CO-.

公开(公告)号：EP1184366A4

公开(公告)日：2002-10-31

申请号：EP00935582

申请日：2000-06-08

申请人： KYORIN SEIYAKU KK

发明人： NOMURA MASAHIRO ,  TAKAHASHI YUKIE ,  TANASE TAKAHIRO ,  MIYACHI HIROYUKI ,  TSUNODA MASAKI ,  IDE TOMOHIRO ,  MURAKAMI KOJI

IPC分类号： A61K31/195 ,  A61K31/222 ,  A61K31/421 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/73 ,  C07C235/60 ,  C07C321/12 ,  C07C321/20 ,  C07C321/28 ,  C07C323/60 ,  C07D263/26 ,  C07C323/62

CPC分类号： C07D263/26 ,  A61K31/195 ,  C07C235/60 ,  C07C323/60

摘要： Novel substituted phenylpropionic acid derivatives capable of binding as a ligand to human peroxisome proliferator-activated receptor α (PPARα) to thereby activate the receptor and thus showing a potent effect of lowering blood lipid (cholesterol and neutral lipid) levels. Substituted phenylpropionic acid derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and hydrates of the same, and process for producing the same.

公开(公告)号：EP1207157A4

公开(公告)日：2002-09-18

申请号：EP00953477

申请日：2000-08-18

申请人： KYORIN SEIYAKU KK

发明人： MIYACHI HIROYUKI ,  NOMURA MASAHIRO ,  TANASE TAKAHIRO ,  MURAKAMI KOJI ,  TSUNODA MASAKI

IPC分类号： A61P3/06 ,  A61P3/10 ,  A61P43/00 ,  C07D277/34 ,  A61K31/426

CPC分类号： C07D277/34

摘要： Substituted benzylthiazolidine-2,4-dione derivatives capable of, as a ligand of human peroxisome proliferator-activated receptor (PPAR), enhancing the transcriptional activity of the receptor and showing effects of lowering blood sugar level and lowering lipid level; and a process for producing the same. Novel substituted benzamide derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and hydrates of the same wherein A represents optionally substituted phenyl, optionally substituted phenoxy or optionally substituted benzyloxy.

摘要翻译： 取代的苄基噻唑烷-2,4-二酮衍生物能够作为人过氧化物酶体增殖物激活受体（PPAR）的配体，增强受体的转录活性并显示出降低血糖水平和降低血脂水平的效果; 及其制造方法。 由通式（1）表示的新型取代的苯甲酰胺衍生物，其药学上可接受的盐及其水合物，其中A代表任选取代的苯基，任选取代的苯氧基或任选取代的苄氧基。