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    DC107 DERIVATIVES
    5.
    发明公开
    DC107 DERIVATIVES 失效
    推出冯DC 107

    公开(公告)号：EP0786462A1

    公开(公告)日：1997-07-30

    申请号：EP96917696.5

    申请日：1996-06-14

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KANDA, Yutaka ,  SAITOH, Yutaka ,  SAITO, Hiromitsu ,  ASHIZAWA, Tadashi ,  SUGIYAMA, Kazuyo ,  GOMI, Katsushige ,  KAKITA, Shingo ,  TAKAHASHI, Yuichi ,  MURAKATA, Chikara

    IPC分类号： C07D513/08 ,  A61K31/425

    CPC分类号： C07D513/08

    摘要： DC107 derivatives represented by the formula (I):
    or pharmacologically acceptable slats thereof,
    [wherein R 1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR 4 or the like; R 2 represents hydrogen or COR 5 ; R 3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R 3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR 6 , with the proviso that the compound wherein R 1 , R 2 and Z each represents hydrogen, R 3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.]

    摘要翻译： 由式（I）代表的DC107衍生物：其或其药理学上可接受的板条，其中R 1是氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR 4等; R 2表示氢或COR 5; R 3表示低级烷基，低级烯基，可被取代或未取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，取代或未取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基烷基，脂环族烷酰氧基烷基等，或与Y键合以表示 单一债券 Y与R 3键合以表示单键，或与Z键合以表示单键; Z表示氢或与Y键合以表示单键; W表示氧或NR 6，条件是其中R 1，R 2和Z各自表示氢，R 3与Y键合以表示单键，W表示氧（DC107 ）被排除在外