-
公开(公告)号：EP0657412B1
公开(公告)日：1998-02-04
申请号：EP94900271.1
申请日：1993-11-17
发明人： NAKANO, Hirofumi , FUJII, Noboru , YAMASHITA, Yoshinori , SAITOH, Yutaka , AGATSUMA, Tsutomu , ANDO, Katsuhiko , NISHIIE, Yasushi , KITA, Katsunori , MORISHIMA, Naoki , GOMI, Katsushige
CPC分类号： C07C305/26 , C07C50/38 , C07C305/22 , C12P29/00
摘要： A saintopin E derivative represented by general formula (I) and useful as an antibacterial and antitumor agent, wherein when R represents hydrogen, then R represents SO2OH (in the case of UCE1022), while when R represents acetyl, then R represents hydrogen (in the case of saintopin E).
-
公开(公告)号：EP0791581A1
公开(公告)日：1997-08-27
申请号：EP96930356.9
申请日：1996-09-11
发明人： MIZUKAMI, Tamio , ASAI, Akira , YAMASHITA, Yoshinori , NAKANO, Hirofumi , KAKITA, Shingo , UOSAKI, Youichi , OCHIAI, Keiko , ASHIZAWA, Tadashi , MIHARA, Akira
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： This invention relates to UCH15 compounds of the formula (I):
wherein R 1 represents a hydrogen atom or a hydroxyl group.摘要翻译： 本发明涉及式（I）的UCH15化合物：其中R1代表氢原子或羟基。
-
3.发明授权
公开(公告)号：EP0271581B1
公开(公告)日：1993-01-13
申请号：EP87902737.3
申请日：1987-04-17
发明人： NAKANO, Hirofumi , TAKAHASHI, Isami , ICHIMURA, Michio , KAWAMOTO, Isao , ASANO, Kozo , TOMITA, Fusao , SANO, Hiroshi , YASUZAWA, Toru , MORIMOTO, Makoto , FUJIMOTO, Kazuhisa
摘要： New cpds. designated DC-88A and DC-89Al are obtd. by culture of Streptomyces species, specifically S. lydicus FERM-BP 988 or S. parvullus FERM-BP 1002. DC-88A has the molecular formula C26H25N3O8, mol. wt. (by EI-MS) 507.1624, and is sol. in methanol, ethanol, acetone, chloroform, ethyl acetate, DMSO; insol. in water, hexane. The Rf on silica gel using toluene/acetone (7:3 v/v) is 0.46. DC-89Al has the molecular formula C26H26N3O8Cl, mol. wt. 543, m.pt. 157.5-58.5 deg.C; sol. in methanol, ethanol, acetone, ethyl acetate, chloroform, DMSO; insol. in water, hexane, IR, UV, 1H NMR, 13C NMR spectral data are given for both cpds.
-
公开(公告)号：EP0670317B9
公开(公告)日：2001-03-14
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
-
公开(公告)号：EP0659752B1
公开(公告)日：1999-03-31
申请号：EP94917806.5
申请日：1994-06-14
发明人： NAKANO, Hirofumi , FUJII, Noboru , MIZUKAMI, Tamio , UOSAKI, Youichi , KITA, Katsunori , KOBAYASHI, Eiji
IPC分类号： C07D493/04 , C12P17/18 , A61K31/35
CPC分类号： C07D493/04 , C12P17/181
摘要： A novel substance DC114-A1 represented by formula (I).
-
6.发明公开NOVEL COMPOUNDS DC-88A AND DC-89A1 AND PROCESS FOR THEIR PREPARATION 失效NEER VERBINDUNGEN DC-88A UND DC-89A1 UND DEREN HERSTELLUNGSVERFAHREN。
公开(公告)号：EP0271581A1
公开(公告)日：1988-06-22
申请号：EP87902737.3
申请日：1987-04-17
发明人： NAKANO, Hirofumi , TAKAHASHI, Isami , ICHIMURA, Michio , KAWAMOTO, Isao , ASANO, Kozo , TOMITA, Fusao , SANO, Hiroshi , YASUZAWA, Toru , MORIMOTO, Makoto , FUJIMOTO, Kazuhisa
摘要： These compounds are prepared by culturing bacteria belonging to the genus Streptomyces. They have antibacterial and oncostatic activities and are useful as medicines.
摘要翻译： 新的cpds。 指定为DC-88A和DC-89A1。 通过Streptomyces物种的培养，特别是S.firidicus FERM-BP 988或小檗菌FERM-BP1002。DC-88A具有分子式C 26 H 25 N 3 O 8，mol。 重量。 （EI-MS）507.1624，为溶胶。 在甲醇，乙醇，丙酮，氯仿，乙酸乙酯，DMSO中; INSOL。 在水中，己烷。 使用甲苯/丙酮（7:3v / v）的硅胶上Rf值为0.46。 DC-89Al具有分子式C26H26N3O8Cl，mol。 重量。 543，m.pt 157.5-58.5℃; 溶胶。 在甲醇，乙醇，丙酮，乙酸乙酯，氯仿，DMSO中; INSOL。 在水，己烷，IR，UV，1 H NMR，13 C NMR光谱数据中给出了两种cpds。
-
公开(公告)号：EP0670317B1
公开(公告)日：2000-03-08
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译： 通式（I）表示的环氧基环己二酮衍生物或其药理学上允许的盐，式中，R表示碳原子数10〜25的直链状或支链状的烷酰基，碳原子数10〜25的直链烯酰基或式（A）所示的基团， 到4.这种化合物具有抗菌和抗肿瘤活性。
-
8.发明公开NOVEL SUBSTANCES DC-92B AND DC-92D, AND PROCESS FOR THEIR PREPARATION 失效NEUE MITTEL DC-92B UND DC-92D，SOWIE DEREN VERFAHREN ZUR HERSTELLUNG。
公开(公告)号：EP0274545A1
公开(公告)日：1988-07-20
申请号：EP87904737.1
申请日：1987-07-17
发明人： NAKANO, Hirofumi , TAKAHASHI, Isami , TOMITA, Fusao , ASANO, Kozo , YASUZAWA, Toru , ASHIZAWA, Tadashi , TAKAHASHI, Keiichi
摘要： Novel compounds DC-928 and DC-92D having an an- thaquinone structure represented by planar structural formula (I) and a process for their preparation. These compounds are produced by cultivating microorganisms belonging to the genus Actinomajula. They have antibacterial and oncostatic activities, thus being useful as medicines. In the formula, R represents a group represented by the formula (II) or (III).
摘要翻译： 式（I）的Anthra（1,2-b）吡喃类抗生素是新的。 R为（II）（抗生素DC-92B）或（III）（抗生素DC-92D）。 县。 制备方法。 包括Actinomadura（特别是Actinomadura sp.DO-92，FERM-P 1019）的菌株的培养物。 县。 抗生素为深红色固体，溶于（m）乙醇，丙酮，氯仿，乙酸乙酯，甲苯和DMSO，但可溶于无机物。 在水和己烷中。 IR，（1）1 H NMR和（13）C NMR光谱数据。
-
公开(公告)号：EP0791581B1
公开(公告)日：2001-10-10
申请号：EP96930356.9
申请日：1996-09-11
发明人： MIZUKAMI, Tamio , ASAI, Akira , YAMASHITA, Yoshinori , NAKANO, Hirofumi , KAKITA, Shingo , UOSAKI, Youichi , OCHIAI, Keiko , ASHIZAWA, Tadashi , MIHARA, Akira
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34
摘要： Compounds UCH 15 represented by general formula (I), wherein R1 represents hydrogen or hydroxy.
-
公开(公告)号：EP0667351B1
公开(公告)日：2000-03-15
申请号：EP94921820.0
申请日：1994-07-26
发明人： NAKANO, Hirofumi , OGAWA, Harumi , YAMASHITA, Yoshinori 3-9-9, Naka-machi , KATAHIRA, Ritsuko , CHIBA, Shigeru , IWASAKI, Toshiaki , ASHIZAWA, Tadashi
IPC分类号： C07H15/24 , C12P19/56 , A61K31/704
CPC分类号： C12P19/56 , C07H15/244
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.012 秒)
