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公开(公告)号：EP0670317A1
公开(公告)日：1995-09-06
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C₁₀-C₂₅ linear or branched alkanoyl, C₁₀-C₂₅ linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译： 由通式（Ⅰ）表示的环氧环己烯二酮衍生物或其药理学上可接受的盐，其中R代表C 10 -C 25直链或支链烷酰基，C 10 -C 25直链烯酰基或式（A）代表的基团，其中n代表整数1 到4.这种化合物具有抗菌和抗肿瘤活性。
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公开(公告)号：EP0670317B9
公开(公告)日：2001-03-14
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
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公开(公告)号：EP0788501B1
公开(公告)日：2002-06-05
申请号：EP95937391.1
申请日：1995-10-04
发明人： LEWIS, Michael, E. , KAUER, James, C. , NEFF, Nicola , GLICKSMAN, Marcie , ROBERTS-LEWIS, Jill , MURAKATA, Chikara , SAITO, Hiromitsu , MATSUDA, Yuzuru , KANAI, Fumihiko , KANEKO, Masami
IPC分类号： C07D498/22 , A61K31/55 , C07D487/14 , A61K31/40
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K2300/00
摘要： The invention features novel derivatives of K-252a e.g. (II-4) as well as novel bis-N-substituted derivatives of staurosporine of Formula (I). The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a. In the formula (I): [Stau] -N(CH3)-W-N(CH3)-[Stau], [Stau] represents a residue of formula (a) and W represents a radical of the formula: -C(=Y)-NH-W'-NH-C(=Y)- where W' is a hydrocarbylene radical of 2-20 carbon atoms and Y is O or S. In formula (II-4) R?1, R2, Z1, and Z2¿ are each H; X is CH¿2?OH; and R is OCH3.
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公开(公告)号：EP0670317B1
公开(公告)日：2000-03-08
申请号：EP94927068.0
申请日：1994-09-20
发明人： KANEKO, Masami , SAITOH, Yutaka , AKINAGA, Shiro , OKABE, Masami , AKASAKA, Kazuhito , NAKANO, Hirofumi
IPC分类号： C07D303/36 , A61K31/335
CPC分类号： C07D303/36
摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.
摘要翻译： 通式（I）表示的环氧基环己二酮衍生物或其药理学上允许的盐，式中，R表示碳原子数10〜25的直链状或支链状的烷酰基，碳原子数10〜25的直链烯酰基或式（A）所示的基团， 到4.这种化合物具有抗菌和抗肿瘤活性。
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公开(公告)号：EP0788501A1
公开(公告)日：1997-08-13
申请号：EP95937391.0
申请日：1995-10-04
发明人： LEWIS, Michael, E. , KAUER, James, C. , NEFF, Nicola , GLICKSMAN, Marcie , ROBERTS-LEWIS, Jill , MURAKATA, Chikara , SAITO, Hiromitsu , MATSUDA, Yuzuru , KANAI, Fumihiko , KANEKO, Masami
CPC分类号： C07D487/14 , A61K31/407 , A61K31/5377 , A61K31/553 , A61K31/7056 , A61K2300/00
摘要： The invention features novel derivatives of K-252a e.g. (II-4) as well as novel bis-N-substituted derivatives of staurosporine of Formula (I). The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a. In the formula (I): [Stau] -N(CH3)-W-N(CH3)-[Stau], [Stau] represents a residue of formula (a) and W represents a radical of the formula: -C(=Y)-NH-W'-NH-C(=Y)- where W' is a hydrocarbylene radical of 2-20 carbon atoms and Y is O or S. In formula (II-4) R?1, R2, Z1, and Z2¿ are each H; X is CH¿2?OH; and R is OCH3.
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