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1.发明授权DIAGNOSTICS AND REMEDIES FOR DISEASES WITH PARTICIPATION OF MACROCYTES/MACROPHAGES 有权诊断以及与参与macrocytes /巨噬细胞疾病救济
公开(公告)号：EP1199565B1
公开(公告)日：2008-10-08
申请号：EP00937283.0
申请日：2000-06-16
CPC分类号： G01N33/74 , G01N33/5055 , G01N33/56966 , G01N33/6893 , G01N2333/475 , G01N2333/52 , G01N2333/71 , G01N2500/00
摘要： Diagnostics and remedies for inflammatory diseases, delayed hypersensitivity, malignant tumor and arteriosclerosis which contain, as the active ingredient, a substance binding to human VEGF receptor Flt-1 or a substance inhibiting signal transduction mediated by human VEGF receptor Flt-1.
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2.发明公开SUBSTANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME 审中-公开天的信号的键的分子在适当的位置1175酪氨酸磷酸化KDR / FLK-1抑制物质及其用途
公开(公告)号：EP1338655A1
公开(公告)日：2003-08-27
申请号：EP01972658.7
申请日：2001-10-02
发明人： SHIBUYA, Masabumi , TAKAHASHI, Tomoko , Furuya, Akiko Tokyo Res. Lab. kyowa Hakko Kog.Co. , Shitara, Kenya Tokyo Res. Lab. Kyowa Hakko Kog.Co
IPC分类号： C12Q1/02 , C12Q1/48 , C12N15/09 , C07K16/18 , C07K14/47 , A61K39/395 , A61P43/00 , A61P35/00 , A61P9/00 , A61K45/00 , G01N33/15 , G01N33/50
CPC分类号： C12Q1/485 , A61K2039/505 , C07K16/2863 , C07K2317/34 , G01N2500/04
摘要： The present invention provides a substance which inhibits binding of a signal transduction molecule to 1175-tyrosine phosphorylated KDR/Flk-1 and inhibits cell growth by VEGF. Also, the present invention provides a method for inhibiting KDR/Flk-1 signal transduction, a method for inhibiting cell growth, a method for inhibiting angiogenesis, a method for screening a cell growth inhibitor, a method for screening an angiogenesis inhibitor, a method for screening a substance which inhibits KDR/Flk-1 signal transduction, a method for determining whether or not a tested substance can inhibit KDR/Flk-1 signal transduction, a method for detecting angiogenesis in tissue and a method for screening a substance which inhibits 1175-tyrosine phosphorylated. KDR/Flk-1, in which each method comprises using the substance.
摘要翻译： 本发明提供一种物质，其抑制信号转导分子的由VEGF KDR磷酸化/的Flk-1和抑制细胞生长1175酪氨酸结合。 所以，本发明提供了一种方法，用于抑制KDR /的Flk-1的信号转导，一种用于抑制细胞生长，一种用于抑制血管生成，用于筛选的细胞生长抑制剂，血管生成抑制剂的筛选方法的方法，一种方法 用于筛选抑制KDR /的Flk-1的信号转导，用于确定性采矿受试物质是否能够抑制KDR /的Flk-1的信号转导，用于检测组织中血管生成的方法和用于筛选物质，其抑制的方法的方法的物质 1175 - 酪氨酸磷酸。 KDR /的Flk-1，其中每个方法包括使用该物质。
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3.发明公开DIAGNOSTICS AND REMEDIES FOR DISEASES WITH PARTICIPATION OF MACROCYTES/MACROPHAGES 有权诊断以及与参与macrocytes /巨噬细胞疾病救济
公开(公告)号：EP1199565A1
公开(公告)日：2002-04-24
申请号：EP00937283.0
申请日：2000-06-16
IPC分类号： G01N33/53 , A61K45/00 , A61K39/395
CPC分类号： G01N33/74 , G01N33/5055 , G01N33/56966 , G01N33/6893 , G01N2333/475 , G01N2333/52 , G01N2333/71 , G01N2500/00
摘要： The present invention relates to a diagnostic agent and a therapeutic agent for inflammatory disease, delayed type hypersensitivity, malignant tumor and arteriosclerosis, which comprises, as an active ingredient, a substance which binds to a human VEGF receptor Flt-1 or a substance which inhibits signal transduction via a human VEGF receptor Flt-1.
摘要翻译： 本发明涉及一种诊断剂和用于炎性疾病的治疗剂，迟发型超敏反应，恶性肿瘤和动脉硬化，其包含作为活性成分，其结合于人VEGF受体Flt-1或者抑制物质的物质 通过人VEGF受体的Flt-第一信号转导
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公开(公告)号：EP1160572A1
公开(公告)日：2001-12-05
申请号：EP00906685.3
申请日：2000-03-03
IPC分类号： G01N33/53 , A61K39/395 , A61K51/10
CPC分类号： G01N33/57426 , G01N2333/705
摘要： The present invention relates to treating and diagnosing leukemia using an anti-human VEGF receptor Flt-1 antibody, and a diagnostic agent and a therapeutic agent comprising the anti-human VEGF receptor Flt-1 antibody as an active ingredient.
摘要翻译： 本发明涉及使用抗人VEGF受体Flt-1抗体治疗和诊断白血病，以及包含抗人VEGF受体Flt-1抗体作为活性成分的诊断剂和治疗剂。
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