公开(公告)号：EP1226752A4

公开(公告)日：2004-05-06

申请号：EP00971708

申请日：2000-11-01

申请人： KYOWA HAKKO KOGYO KK

发明人： MORI KATSUHIRO ,  SATO MITSUO ,  SEKINE SUSUMU

IPC分类号： A01K67/027 ,  C07K14/435 ,  C12N15/85 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： A01K67/0275 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0393 ,  C07K14/43595 ,  C12N15/8509 ,  C12N2800/30

摘要： Transgenic non-human mammals which have a DNA encoding a foreign reporter gene for monitoring a change in the calcium ion concentration in cells and express this reporter protein in one or more types of non-nerve cells; a method of constructing the above transgenic non-human mammals; a method of detecting a change in the calcium ion concentration in cells by using the above transgenic non-human mammals; a DNA having a promoter activity to be used in the construction; and a method of utilizing this DNA. The non-human mammals as described above, which express the above DNA in one or more tissues or organs selected from the group consisting of epithelial tissues, binding tissues, fat tissues, cartilage tissues, bone tissues, muscle tissues, oral cavity tissues, blood tissues, bone marrow, circulatory organs, lymphoid tissues, teeth, digestive organs, liver, gall, pancreas, respiratory organs, urinary organs, genital organs, endocrine organs, sensory organs and nails, are usable in evaluating the pharmacological effects and activities of physiologically active substances (for example, drugs), novel gene products with unknown functions, etc.

公开(公告)号：EP1688439A4

公开(公告)日：2007-12-19

申请号：EP04773776

申请日：2004-10-08

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  HOSAKA EMI ,  NATSUME AKITO ,  WAKITANI MASAKO ,  UCHIDA KAZUHISA ,  SATO MITSUO ,  OHNUKI NAOKO ,  NAKAMURA KAZUYASU

IPC分类号： A61K38/17 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07K14/705 ,  C07K14/715 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/62 ,  C12P21/08

CPC分类号： C07K16/30 ,  A61K38/00 ,  C07K14/70528 ,  C07K14/7151 ,  C07K16/00 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32 ,  C12N9/1051 ,  C12N9/88 ,  C12N9/90

摘要： There has been required a fused protein composition of the Fc domain of an antibody which has an enhanced effector function and is useful as a drug. Thus it is intended to provide a composition comprising a fused protein molecule of the Fc domain of an antibody which has an N-glycoside-binding complex sugar chain in the Fc domain, wherein the N-glycoside-binding complex sugar chain is a sugar chain having no fucose attached to N-acetylglucosamine at the reducing end of the sugar chain; a transformant producing this fused protein composition; a process for producing the fused protein composition; and a drug containing the fused protein composition.