公开(公告)号：EP3138470A1

公开(公告)日：2017-03-08

申请号：EP16191274.6

申请日：2015-01-21

申请人： Kabushiki Kaisha Topcon

发明人： YANG, Qi ,  REISMAN, Charles A.

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G06T7/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/64 ,  G06T5/00 ,  G01N21/17 ,  G01N21/88

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/1225 ,  A61B5/4842 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/887 ,  G06K9/00617 ,  G06K9/4604 ,  G06K9/4671 ,  G06K9/52 ,  G06K2009/4666 ,  G06T5/002 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： The present invention relates to a method of processing acquired ophthalmic image data comprising: providing an imaging signal produced by a imaging device, the imaging signal having a center wavelength of at least 1μm or being a polarization-sensitive optical coherence tomography (PS-OCT) signal; detecting intensities of the imaging signal as the imaging signal is backscattered by each of a plurality of tissue layers in a subject's eye for a plurality of axial scans; determining a ratio of the intensities of the backscattered imaging signals for each of the plurality of axial scans, the ratio being the intensity of a first portion of the backscattered imaging signal with respect to the intensity of a second portion of the backscattered imaging; identifying areas of the subject's eye based at least in part on the determined ratio.

摘要翻译： 本发明涉及一种处理所获得的眼科图像数据的方法，包括：提供由成像装置产生的成像信号，所述成像信号具有至少1¼m的中心波长或者是偏振光学相干断层扫描（PS-OCT） 信号; 当成像信号由对象眼睛中的多个组织层中的每一个反向散射以进行多次轴向扫描时，检测成像信号的强度; 确定所述多个轴向扫描中的每一个的反向散射成像信号的强度的比率，所述比率是所述背散射成像信号的第一部分的强度相对于背散射成像的第二部分的强度; 至少部分地基于所确定的比例来识别对象的眼睛的区域。

公开(公告)号：EP3138470B1

公开(公告)日：2018-12-26

申请号：EP16191274.6

申请日：2015-01-21

申请人： Kabushiki Kaisha Topcon

发明人： YANG, Qi ,  REISMAN, Charles A.

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G06T7/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/64 ,  G06T5/00 ,  G01N21/17 ,  G01N21/88 ,  A61B5/00 ,  G06K9/00 ,  G06K9/52 ,  G06K9/46

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1025 ,  A61B3/12 ,  A61B3/1225 ,  A61B5/4842 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/887 ,  G06K9/00617 ,  G06K9/4604 ,  G06K9/4671 ,  G06K9/52 ,  G06K2009/4666 ,  G06T5/002 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time.

公开(公告)号：EP3054420B1

公开(公告)日：2018-09-05

申请号：EP16151249.6

申请日：2016-01-14

申请人： KABUSHIKI KAISHA TOPCON

发明人： REISMAN, Charles A. ,  YANG, Qi

IPC分类号： G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time to phenotype subjects and classify diseases.

公开(公告)号：EP3082101A3

公开(公告)日：2016-10-26

申请号：EP16165027.0

申请日：2016-04-13

申请人： Kabushiki Kaisha TOPCON

发明人： REISMAN, Charles A. ,  WANG, Zhenguo ,  KUBOTA, Atsushi ,  LIU, Jonathan

IPC分类号： G06T5/50

CPC分类号： G06T7/0012 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/7257 ,  A61B5/7425 ,  G06K9/52 ,  G06K9/6215 ,  G06T5/50 ,  G06T2207/10101 ,  G06T2207/20052 ,  G06T2207/20212 ,  G06T2207/30041 ,  G06T2207/30101 ,  G06T2207/30104

摘要： Methods and systems for angiographic imaging with optical coherence tomography (OCT) are described using ratio-based and angiographic deviation based calculations. In using these calculations to determine motion, arbitrary interframe permutations may be used, post-calculated, non-linear results for projection visualization may be averaged, poor matches may be eliminated on an A-line by A-line basis, windowing functions may be used to improve results, partial spectrums may be used when capturing data, and a minimum intensity threshold may be used for determining which pixels to use.

公开(公告)号：EP3054420A3

公开(公告)日：2016-11-09

申请号：EP16151249.6

申请日：2016-01-14

申请人： Kabushiki Kaisha TOPCON

发明人： REISMAN, Charles A. ,  YANG, Qi

IPC分类号： G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time to phenotype subjects and classify diseases.

公开(公告)号：EP3082101A2

公开(公告)日：2016-10-19

申请号：EP16165027.0

申请日：2016-04-13

申请人： Kabushiki Kaisha TOPCON

发明人： REISMAN, Charles A. ,  WANG, Zhenguo ,  KUBOTA, Atsushi ,  LIU, Jonathan

IPC分类号： G06T5/50

CPC分类号： G06T7/0012 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/7257 ,  A61B5/7425 ,  G06K9/52 ,  G06K9/6215 ,  G06T5/50 ,  G06T2207/10101 ,  G06T2207/20052 ,  G06T2207/20212 ,  G06T2207/30041 ,  G06T2207/30101 ,  G06T2207/30104

摘要： Methods and systems for angiographic imaging with optical coherence tomography (OCT) are described using ratio-based and angiographic deviation based calculations. In using these calculations to determine motion, arbitrary interframe permutations may be used, post-calculated, non-linear results for projection visualization may be averaged, poor matches may be eliminated on an A-line by A-line basis, windowing functions may be used to improve results, partial spectrums may be used when capturing data, and a minimum intensity threshold may be used for determining which pixels to use.

摘要翻译： 使用基于比例和血管造影偏差的计算描述了使用光学相干断层扫描（OCT）进行血管造影成像的方法和系统。 在使用这些计算来确定运动时，可以使用任意的帧间排列，后计算，用于投影可视化的非线性结果可以被平均，可以通过A线在A线上消除不良匹配，窗口函数可以是 用于改善结果时，可以在捕获数据时使用部分光谱，并且可以使用最小强度阈值来确定要使用的像素。

公开(公告)号：EP3054420A2

公开(公告)日：2016-08-10

申请号：EP16151249.6

申请日：2016-01-14

申请人： Kabushiki Kaisha TOPCON

发明人： REISMAN, Charles A. ,  YANG, Qi

IPC分类号： G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Geographic atrophy of the eye can be detected and measured by imaging the eye at a depth greater than the retinal pigment epithelium (RPE) at a plurality of locations of the eye, for example, using optical coherence tomography (OCT); determining a ratio of the intensities of imaging signals of a retinal layer(s) with respect to the intensity of imaging signals of a sub-RPE layer(s) at each location; determining representative values based at least in part on the determined ratios; generating a map of the representative values; and identifying diseased areas from the map. Contours and binary maps may be generated based on the identified diseased areas. The size and shape of the identified areas may be analyzed and monitored over a period of time to phenotype subjects and classify diseases.

摘要翻译： 可以通过使用光学相干断层扫描（OCT）在眼睛的多个位置处以大于视网膜色素上皮（RPE）的深度成像眼睛来检测和测量眼睛的地理萎缩。 确定视网膜层的成像信号的强度相对于每个位置处的子RPE层的成像信号的强度的比率; 至少部分地基于所确定的比率确定代表值; 生成代表值的地图; 并从地图中识别患病区域。 可以基于所识别的患病区域来生成轮廓和二进制图。 识别区域的大小和形状可以在一段时间内进行分析和监测，以表型受试者和分类疾病。