公开(公告)号：EP3460463A1

公开(公告)日：2019-03-27

申请号：EP18160783.9

申请日：2018-03-08

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： ATSUTA, Masaki ,  YAMADA, Ko ,  NAKAMURA, Hiroko ,  OKI, Mitsuhiro ,  MIYAMOTO, Hirohisa ,  SHINJO, Yasushi ,  YOSHIMURA, Reiko

IPC: G01N27/414

Abstract: A molecular detection apparatus, comprising: a chamber; a light source provided in the chamber and configured to emit light; a detector including at least one sensor and configured to generate a first detection data and a second detection data, the sensor being provided in the chamber and being configured to capture molecules of target molecules, the first detection data corresponding to the number of captured molecules per predetermined time under a first emission condition of the light, and the second detection data corresponding to the number of captured molecules per predetermined time under a second emission condition of the light; and a discriminator to discriminate the target molecules using the first and second detection data.

公开(公告)号：EP3348999A1

公开(公告)日：2018-07-18

申请号：EP15903517.9

申请日：2015-09-10

Applicant: Kabushiki Kaisha Toshiba

Inventor： YAMADA, Ko ,  YOSHIMURA, Reiko ,  MIYAMOTO, Hirohisa ,  OSADA, Norikazu ,  OKI, Mitsuhiro ,  NAKAMURA, Hiroko

IPC: G01N27/00 ,  G01N27/62

CPC classification number: G01N27/4148 ,  B82Y30/00 ,  G01N27/27 ,  G01N27/4141 ,  G01N27/4145 ,  G01N27/4146

Abstract: A molecular detection apparatus according to an arrangement includes a detector and a discriminator. The detector includes a plurality of detection cells, where the plurality of detection cells include at least an organic probe containing a cyano group or a nitro group as a neighboring group of a reactive group. The discriminator discriminates a substance to be detected by signal patterns of the plurality of detection cells.

公开(公告)号：EP3296731A1

公开(公告)日：2018-03-21

申请号：EP17156678.9

申请日：2017-02-17

Applicant: Kabushiki Kaisha Toshiba

Inventor： YAMADA, Ko ,  MIYAMOTO, Hirohisa ,  YOSHIMURA, Reiko ,  OSADA, Norikazu ,  NAKAMURA, Hiroko ,  OKI, Mitsuhiro

IPC: G01N27/414

CPC classification number: G01N33/0037 ,  G01N27/4141 ,  G01N27/4146 ,  H01L29/1606 ,  Y02A50/245

Abstract: A molecular detection apparatus includes: a collection unit collecting detection target gas containing molecules (2) to be detected; a detector (20) including detection cells (201) having an organic probe (22) provided at a sensor unit (21), for example a graphene (26) field-effect transistor, the organic probe capturing the collected molecule to be detected; and a discriminator discriminating the molecule to be detected by a detection signal generated by the molecule being captured by the organic probe. The detection cell has the organic probe containing a phosphonic acid structure or phosphoric acid structure. The organic probe comprises a polycyclic aromatic hydrocarbon group as base portion, a connecting portion and a head portion containing thze phosphonic or phosphoric acid structure.

Abstract translation: 一种分子检测装置包括：收集单元，收集包含待检测分子（2）的检测目标气体; 包括检测单元（201）的检测器（20），所述检测单元具有设置在传感器单元（21）处的有机探针（22），例如石墨烯（26）场效应晶体管，所述有机探针捕获所收集的待检测分子; 以及鉴别器，其通过由有机探针捕获的分子产生的检测信号来鉴别待检测的分子。 检测池具有含有膦酸结构或磷酸结构的有机探针。 有机探针包含多环芳族烃基作为基础部分，连接部分和含有膦酸或磷酸结构的头部。

公开(公告)号：EP3336532A1

公开(公告)日：2018-06-20

申请号：EP15900951.3

申请日：2015-08-12

Applicant: Kabushiki Kaisha Toshiba

Inventor： YAMADA, Ko ,  MIYAMOTO, Hirohisa ,  OSADA, Norikazu ,  OKI, Mitsuhiro ,  NORITOMI, Yasuko

IPC: G01N27/62 ,  G01N27/00

CPC classification number: G01N27/4141 ,  G01N27/62 ,  G01N27/622

Abstract: A molecular detection apparatus according to an arrangement includes: a distributor which ionizes a target containing substances to be detected, applies voltage to ionized substances, and extracts the substances to be detected according to a time-of-flight based on the speed; a detector which detects the substance to be detected dropped from the distributor; and a discriminator which discriminates the substance to be detected. The detector includes: a plurality of detection units including field effect transistors using graphene layers; and a plurality of organic probes which are provided on the graphene layers, and at least some of which have different bond strengths with the substances to be detected. The substance to be detected is discriminated depending on a signal pattern based on intensity differences of the detection signals generated by differences in the bond strengths between the organic probes and the substances to be detected.

公开(公告)号：EP3296730A1

公开(公告)日：2018-03-21

申请号：EP17155881.0

申请日：2017-02-13

Applicant: Kabushiki Kaisha Toshiba

Inventor： MIYAMOTO, Hirohisa ,  YAMADA, Ko ,  YOSHIMURA, Reiko

IPC: G01N27/414

CPC classification number: G01N27/4148 ,  G01N1/34 ,  G01N27/27 ,  G01N27/4141 ,  G01N27/4146 ,  G01N33/0037

Abstract: A molecular detection apparatus includes: a collection unit (10) collecting detection target gas containing molecules (2) to be detected; a detector (20) including a plurality of detection cells (201) each having an organic probe (22) disposed at a sensor unit (23), for example a graphene (26) field-effect transistor (21), the organic probe capturing the molecules collected in the collection unit; and a discriminator discriminating the molecules by a signal pattern based on an intensity difference of detection signals generated by the molecules being captured by the organic probes in a plurality of the detection cells. In the molecular detection apparatus according to the embodiment, at least one of the detection cells has a plurality of different types of the organic probes disposed at the sensor unit. Hereby changes the mixing ratio of the different organic probe types systematically across the sensor array. The organic probes comprise a polycyclic aromatic hydrocarbon group as base portion, a connecting portion and a head portion containing a reactive group and a neighbouring group.

Abstract translation: 分子检测装置包括：收集单元（10），收集待检测的含检测目标气体的分子（2）;检测单元 包括多个检测单元（201）的检测器（20），每个检测单元具有设置在传感器单元（23）处的有机探针（22），例如石墨烯（26）场效应晶体管（21），有机探针捕获 在收集单元中收集的分子; 以及鉴别器，该鉴别器基于由多个检测单元中的有机探针捕获的分子产生的检测信号的强度差异以信号图案来识别分子。 在根据该实施例的分子检测装置中，至少一个检测单元具有设置在传感器单元处的多种不同类型的有机探针。 由此跨传感器阵列系统地改变不同有机探针类型的混合比率。 有机探针包含多环芳烃基团作为基础部分，连接部分和含有反应性基团和邻近基团的头部。

公开(公告)号：EP3460573A1

公开(公告)日：2019-03-27

申请号：EP18162333.1

申请日：2018-03-16

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： NAKAMURA, Hiroko ,  ASAKAWA, Koji ,  KIHARA, Naoko ,  YOSHIMURA, Reiko ,  YAMADA, Ko

IPC: G03F7/004 ,  G03F7/039

Abstract: A photosensitive composition of an arrangement includes: a resin containing at least one selected from polyacrylic acid, polymethacrylic acid, a cycloolefin-maleic anhydride copolymer, polycycloolefin, and a vinyl ether-maleic anhydride copolymer and having an ester bond which is caused to generate carboxylic acid by an acid or an ether bond which is caused to generate alcohol by an acid; and a photo acid generator which generates an acid by being irradiated with light, of which a wavelength is not less than 300 nm nor more than 500 nm, or KrF excimer laser light, the photo acid generator containing a substance that has a naphthalene ring or a benzene ring and in which at least one carbon atom of the naphthalene ring or the benzene ring is bonded to a bulky group.

公开(公告)号：EP3457122A1

公开(公告)日：2019-03-20

申请号：EP18160219.4

申请日：2018-03-06

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： YAMADA, Ko ,  MIYAMOTO, Hirohisa ,  YOSHIMURA, Reiko ,  NAKAMURA, Hiroko ,  OKI, Mitsuhiro ,  SHINJO, Yasushi ,  ATSUTA, Masaki

IPC: G01N27/414 ,  G01N33/00

Abstract: A molecular detection apparatus according to an arrangement includes: a collection unit collecting a detection target gas containing a molecule to be detected; a detector including a detection cell that has an organic probe provided in a sensor unit, for example a graphene field effect transistor (GFET), the organic probe capturing the collected molecule, and a discriminator discriminating the molecule by a detection signal generated by the molecule being captured by the organic probe of the detection cell. The detection cell has the organic probe including a dicyanovinyl structure (for example ORGANIC COMPOUND 2A) or a coumarin (for example ORGANIC COMPOUND 2B) structure.

公开(公告)号：EP3379244A1

公开(公告)日：2018-09-26

申请号：EP17192161.2

申请日：2017-09-20

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： OKI, Mitsuhiro ,  MIYAMOTO, Hirohisa ,  YAMADA, Ko

IPC: G01N33/00

CPC classification number: G01N30/54 ,  G01N30/70 ,  G01N33/0018 ,  G01N33/0031 ,  G01N2030/025 ,  G01N2033/0019

Abstract: A molecular detection apparatus (1) according to an arrangement includes: a collection unit (10) which collects detection target gases (3) each containing molecule (2) to be detected; a concentration adjusting unit (20) which dilutes and/or concentrates the molecule, and generates a plurality of detection target gases having different concentrations of the molecule (2); a detection unit (30) to which the plurality of detection target gases (3) are sequentially introduced, and which includes a plurality of detection cells (301) each outputting detection signals based on the concentrations of the molecule (2) in the plurality of detection target gases (3); and a discrimination unit (40) which discriminates the molecule (2) by change tendencies of the detection signals based on the concentrations of the molecule (2) output. Discrimination of gases is performed by using the plurality of detection cells (301) where each cell has a different dependency of cell response to gas concentration and the target detection gas (3) is successively interrogated by the the detection cells (301) after successive dilutions or concentrations of the target detection gas.