公开(公告)号：EP3925620A1

公开(公告)日：2021-12-22

申请号：EP20754881.9

申请日：2020-02-07

申请人： Kao Corporation ,  Shizuoka Prefectural University Corporation

发明人： ONISHI, Shintaro ,  MORI, Takuya ,  SUZUKI, Takashi ,  KUREBAYASHI, Yuuki

IPC分类号： A61K39/145 ,  C07K7/06 ,  C12N7/00 ,  C12N7/02 ,  C12N15/12

摘要： Provided is a method for efficiently proliferating an influenza virus serving as a material for vaccine in a host.
A method for proliferating an influenza virus in a host, comprising a step of inhibiting transfer of Bax in a host cell to the inner mitochondrial membrane.

公开(公告)号：EP4159284A1

公开(公告)日：2023-04-05

申请号：EP21813509.3

申请日：2021-05-21

申请人： Shizuoka Prefectural University Corporation ,  Nikken Foods Company Limited

发明人： MINAMI, Akira ,  SUZUKI, Takashi ,  IWAO, Yasunori

IPC分类号： A61Q19/08 ,  A61K8/66

摘要： The present invention provides a novel elastin production promoter. The elastin production promoter contains sialidase as an active ingredient.

公开(公告)号：EP3769760A1

公开(公告)日：2021-01-27

申请号：EP19770520.5

申请日：2019-03-20

申请人： Kao Corporation

发明人： IWASHITA, Masazumi ,  SUZUKI, Takashi

IPC分类号： A61K31/352 ,  A61K9/10 ,  A61K47/26 ,  A61P25/28 ,  A61P43/00

摘要： Provided are a nobiletin composition having excellent solubility in water and a method for simply producing the same. A method for producing a solid dispersion containing nobiletin, the method involving a step of dissolving nobiletin or a nobiletin-containing substance and a water-soluble hesperidin derivative selected from the group consisting of glucosyl hesperidin and methyl hesperidin in an ethanol aqueous solution having an ethanol concentration of from 20 to 90 vol% and a step of drying the solution.

公开(公告)号：EP3733155A1

公开(公告)日：2020-11-04

申请号：EP18895719.5

申请日：2018-12-27

申请人： Kao Corporation

发明人： SUZUKI, Takashi ,  ABE, Tetsuya ,  TAKAHASHI, Rui ,  ENDO, Koji ,  HAGURA, Toyoki ,  IWAI, Hidetaka ,  HORIZUMI, Teruo ,  AOSAKI, Taisuke ,  UDA, Akihiro ,  NAKAMICHI, Masato

IPC分类号： A61K8/34 ,  A61K8/02 ,  A61K8/37 ,  A61K9/08 ,  A61K47/10

摘要： To provide a new method for producing a composition containing a hardly water-soluble aromatic compound, the composition having outstanding hardly water-soluble aromatic compound.
A method for producing a composition containing a hardly water-soluble aromatic compound, comprising:
Step (1) of obtaining a hardly water-soluble aromatic compound solution 1, Step (1) comprising Step (1-1) of preparing a material for heating comprising (A) a hardly water-soluble aromatic compound, (B) a polyol, and (C) an aqueous medium, and Step (1-2) of obtaining a heated solution containing a hardly water-soluble aromatic compound by heating the material for heating at normal pressure at a temperature of less than 100°C; and
Step (2) of obtaining a hardly water-soluble aromatic compound solution 2 by adding water to the hardly water-soluble aromatic compound solution 1 such that the hardly water-soluble aromatic compound solution 2 has a concentration of the (A) hardly water-soluble aromatic compound above a saturation solubility at 25°C, wherein, in Step (1), a content of a surfactant in the material for heating is 0.1 mass% or less and a content of the (A) hardly water-soluble aromatic compound in the material for heating is below a saturation solubility of the (A) hardly water-soluble aromatic compound in a solvent having the same composition at 25°C.