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公开(公告)号：EP2978753A1
公开(公告)日：2016-02-03
申请号：EP14718338.8
申请日：2014-03-25
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , KOUKNI, Mohamed , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D223/04 , C07D231/12 , C07D333/22 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/06
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
摘要翻译： 本发明涉及一系列新化合物，通过使用新化合物预防或治疗动物中的病毒感染的方法和用作药物的所述新化合物，更优选用作治疗或预防病毒感染的药物， 特别是RNA病毒的感染，更特别是属于黄病毒科的病毒感染，更特别是登革热病毒的感染。 本发明还涉及新化合物的药物组合物或组合制剂，用作药物的组合物或制剂，更优选用于预防或治疗病毒感染。 本发明还涉及化合物的制备方法。
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公开(公告)号：EP2462122A1
公开(公告)日：2012-06-13
申请号：EP10743082.9
申请日：2010-08-05
发明人： CHALTIN, Patrick , DEBYSER, Zeger , DE MAEYER, Marc , MARCHAND, Arnaud , MARCHAND, Damien , SMETS, Wim , VOET, Arnout , CHRIST, Frauke
IPC分类号： C07D239/26 , C07D239/42 , A61K31/505 , A61P31/18
CPC分类号： C07D491/052 , C07D239/26 , C07D239/38 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.
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公开(公告)号：EP4452254A2
公开(公告)日：2024-10-30
申请号：EP22912765.9
申请日：2022-12-23
发明人： VANDERHOYDONCK, Bart , MARCHAND, Arnaud , GWALTNEY II, Stephen L. , SMETS, Wim , CANDI, Aurélie , VERSELE, Matthias , KILONDA, Amuri
IPC分类号： A61K31/33 , A61K31/395 , A61K31/519 , A61K31/505
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公开(公告)号：EP2760831A1
公开(公告)日：2014-08-06
申请号：EP12775463.8
申请日：2012-09-26
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , McNAUGHTON, Michael , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim , KOUKNI, Mohamed
IPC分类号： C07D209/14 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D413/08 , C07D413/12 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D209/14 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/08 , C07D409/12 , C07D413/06 , C07D413/08 , C07D413/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
摘要翻译： 本发明涉及一系列新化合物，通过使用新化合物预防或治疗动物中的病毒感染的方法和用作药物的所述新化合物，更优选用作治疗或预防病毒感染的药物， 特别是RNA病毒的感染，更特别是属于黄病毒科的病毒感染，更特别是登革热病毒的感染。 本发明还涉及新化合物的药物组合物或组合制剂，用作药物的组合物或制剂，更优选用于预防或治疗病毒感染。 本发明还涉及化合物的制备方法。
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公开(公告)号：EP4452936A2
公开(公告)日：2024-10-30
申请号：EP22912764.2
申请日：2022-12-23
发明人： VANDERHOYDONCK, Bart , MARCHAND, Arnaud , GWALTNEY II, Stephen L. , SPIESER, Stéphane , SMETS, Wim , CANDI, Aurélie , VERSELE, Matthias
IPC分类号： C07D209/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D401/10 , C07D247/02
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公开(公告)号：EP4452253A2
公开(公告)日：2024-10-30
申请号：EP22912762.6
申请日：2022-12-23
发明人： VANDERHOYDONCK, Bart , MARCHAND, Arnaud , GWALTNEY, Stephen, L. , SPIESER, Stephane , SMETS, Wim , CANDI, Aurelie , VERSELE, Matthias , HALDER, Georg
IPC分类号： A61K31/33 , A61K31/395 , A61K31/13 , A61K31/454
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公开(公告)号：EP2978753B1
公开(公告)日：2020-08-12
申请号：EP14718338.8
申请日：2014-03-25
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , KOUKNI, Mohamed , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D223/04 , C07D231/12 , C07D333/22 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/06
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公开(公告)号：EP3617192A1
公开(公告)日：2020-03-04
申请号：EP19183201.3
申请日：2012-09-26
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , McNAUGHTON, Michael , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim , KOUKNI, Mohamed
IPC分类号： C07D209/14 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/08 , C07D409/12 , C07D413/08 , C07D413/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/404 , A61P31/14
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
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