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1.发明授权INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权维生素D VERBINDUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN INDOLAMIDDERIVATE
公开(公告)号：EP2440550B1
公开(公告)日：2017-03-15
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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2.发明公开NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权N - （（1H-吲哚-3-基）烷基）-4-苄基）苯甲酰胺，和N - （（1H-吡咯并[2,3-b]吡啶-3-基）烷基）-4-苄基） 苯甲酰胺衍生物作为α-突触核蛋白聚集抑制剂用于治疗神经变性疾病的治疗
公开(公告)号：EP2651888A1
公开(公告)日：2013-10-23
申请号：EP11805450.1
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , ALLASIA, Sara , MARCHAND, Arnaud , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1) wherein R
1 , R
2 , R
4 , R
6 , E, n, Y
1 , Y
2 , Y
3 , Y
4 , Y
5 , L, B, R
8 , and m are as defined in the claims.-
3.发明公开NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权N-（2-（5-取代的-1H-吲哚-3-基）乙基）联苯-4-甲酰胺衍生物和相关化合物作为τ聚集诱导的毒性抑制剂的神经变性疾病的治疗
公开(公告)号：EP2651887A1
公开(公告)日：2013-10-23
申请号：EP11804532.7
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/18 , C07D209/14 , C07D401/12 , C07D409/12 , C07D471/04
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1), wherein R
1 , R
2 , R
4 , R
5 , R
6 , E, n, Y
1 , Y
2 , Y
3 , Y
4 , Y
5 , B, R
8 , and m are as defined in the claims.-
4.发明公开INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权INDOLAMIDDERIVATE和神经退行性疾病的治疗相关的化合物
公开(公告)号：EP2440550A1
公开(公告)日：2012-04-18
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
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5.发明授权N-(2-(5-substituted-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide derivatives and related compounds as Tau-aggregation induced toxicity inhibitors for the treatment of neurodegenerative disorders 有权N-（2-（5-取代的-1H-吲哚-3-基）乙基）联苯-4-甲酰胺衍生物和相关化合物作为τ聚集诱导的毒性抑制剂的神经变性疾病的治疗
公开(公告)号：EP2651887B1
公开(公告)日：2016-08-24
申请号：EP11804532.7
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/18 , C07D209/14 , C07D401/12 , C07D409/12 , C07D471/04
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6.发明公开
公开(公告)号：EP3621963A1
公开(公告)日：2020-03-18
申请号：EP18728316.3
申请日：2018-05-11
发明人： GRIFFIOEN, Johan, Gerard , PRINCEN, Katrien , VAN DOOREN, Tom, François, L. , MARCHAND, Arnaud, Didier, Marie , KILONDA, Amuri , ALLASIA, Sara , CHALTIN, Patrick
IPC分类号： C07D413/12 , A61K31/422 , A61P25/28
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7.发明授权N-((1H-indol-3-yl)-alkyl)-4-benzyl)benzamide and N-((1H-pyrrolo[2,3-b]pyridin-3-yl)-alkyl)-4-benzyl)benzamide derivatives as alpha synuclein aggregation inhibitors for the treatment of neurodegenerative disorders 有权N-（（1H-吲哚-3-基） - 烷基）-4-苄基）苯甲酰胺和N - （（1H-吡咯并[2,3-b]吡啶-3-基） - 烷基）-4-苄基） 苯甲酰胺衍生物α-突触核蛋白聚集抑制剂zur Behandlung von neurodegenerativen Erkrankungen
公开(公告)号：EP2651888B1
公开(公告)日：2017-05-17
申请号：EP11805450.1
申请日：2011-12-13
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Verónica , ALLASIA, Sara , MARCHAND, Arnaud , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D209/14 , C07D471/04 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/4045 , A61P25/28 , A61P25/16
CPC分类号： C07D209/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
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