公开(公告)号：EP2495568B1

公开(公告)日：2018-08-22

申请号：EP10826878.0

申请日：2010-10-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： Tanigawara, Yusuke ,  Suzuki, Sayo ,  Irie, Hidehiro ,  Nishimuta, Akito ,  Suzuki, Tetsuya ,  Sugimoto, Shinji

IPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N33/574

CPC分类号： G01N33/574 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N2800/52 ,  A61K2300/00

摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker. The marker for determining sensitivity to an anti-cancer agent is formed of a protein selected from the group consisting of a protein or a fragment thereof which is detected as a peak at m/z of 16,450 to 16,620, a protein or a fragment thereof which is detected as a peak at m/z of 22,080 to 22,310, and a protein or a fragment thereof which is detected as a peak at m/z of 17,100 to 17,270, the peaks being determined by means of a mass spectrometer.

公开(公告)号：EP2698637B1

公开(公告)日：2015-08-12

申请号：EP13005363.0

申请日：2009-01-30

申请人： Keio University ,  KABUSHIKI KAISHA YAKULT HONSHA

发明人： Tanigawara, Yusuke ,  Watanabe, Mitsuhiro ,  Arita, Eri ,  Nishimuta, Akito ,  Yamayoshi, Yasuko ,  Matsuzaki, Takeshi ,  Sugimoto, Shinji

IPC分类号： G01N33/68 ,  A61K31/4745 ,  A61K45/00 ,  A61P35/00 ,  G01N27/447 ,  G01N27/62 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K31/4745 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/6812 ,  G01N2800/52 ,  Y10S436/813 ,  A61K2300/00

公开(公告)号：EP2698637A1

公开(公告)日：2014-02-19

申请号：EP13005363.0

申请日：2009-01-30

申请人： Keio University ,  KABUSHIKI KAISHA YAKULT HONSHA

发明人： Tanigawara, Yusuke ,  Watanabe, Mitsuhiro ,  Arita, Eri ,  Nishimuta, Akito ,  Yamayoshi, Yasuko ,  Matsuzaki, Takeshi ,  Sugimoto, Shinji

IPC分类号： G01N33/68 ,  A61K31/4745 ,  A61K45/00 ,  A61P35/00 ,  G01N27/447 ,  G01N27/62 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K31/4745 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/6812 ,  G01N2800/52 ,  Y10S436/813 ,  A61K2300/00

摘要： Provided are a marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a substance in a metabolic pathway in which L-phenylalanine and/or N,N-dimethyl glycine are/is involved.

摘要翻译： 提供了用于确定对能够区分个体患者的治疗反应的抗癌剂的敏感性的标记和使用该标记的癌症治疗的新手段。 用于确定对抗癌剂的敏感性的标记物含有涉及L-苯丙氨酸和/或N，N-二甲基甘氨酸的代谢途径中的物质。

公开(公告)号：EP2495568A1

公开(公告)日：2012-09-05

申请号：EP10826878.0

申请日：2010-10-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： Tanigawara, Yusuke ,  Suzuki, Sayo ,  Irie, Hidehiro ,  Nishimuta, Akito ,  Suzuki, Tetsuya ,  Sugimoto, Shinji

IPC分类号： G01N33/68 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00 ,  G01N27/62 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/574 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N2800/52 ,  A61K2300/00

摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.
The marker for determining sensitivity to an anti-cancer agent is formed of a protein selected from the group consisting of a protein or a fragment thereof which is detected as a peak at m/z of 16,450 to 16,620, a protein or a fragment thereof which is detected as a peak at m/z of 22,080 to 22,310, and a protein or a fragment thereof which is detected as a peak at m/z of 17,100 to 17,270, the peaks being determined by means of a mass spectrometer.

摘要翻译： 为了提供用于确定患者对抗癌剂的敏感性的标记，以及采用该标记的新型癌症治疗手段。 用于测定对抗癌剂的敏感性的标志物由选自下列的蛋白质形成：作为m / z为16,450至16,620的峰检测的蛋白质或其片段，其蛋白质或其片段，其蛋白质或其片段 被检测为m / z为22,080至22,310的峰，以及在17,100至17,270的m / z处被检测为峰的蛋白质或其片段，所述峰通过质谱仪测定。