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公开(公告)号：EP0857080A1
公开(公告)日：1998-08-12
申请号：EP96926361.0
申请日：1996-07-18
CPC分类号： B01J19/0093 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0066 , B01F13/0094 , B01J2219/00783 , B01J2219/00822 , B01J2219/00889 , B01L3/5027 , Y10S366/03
摘要： Disclosed is a static micromixer with a mixing chamber and a duct component upstream of the former for separate feeding to the mixing chamber of the fluids to be mixed or dispersed. The aim of the invention is to design the duct component in a static mixer of this generic type in such a way as to improve the efficiency of the mixing process in the mixing chamber. The invention is characterised by the following features: a) the wafer-like elements A and B for the duct component each consist of thin films with a thickness of 10-1000 microns, preferably
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公开(公告)号：EP0391895A1
公开(公告)日：1990-10-17
申请号：EP88902400.0
申请日：1988-03-17
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , SCHMID, Peter , BICHLER, Peter , BRUNNER, Winfried , SIMON, Wolfgang
CPC分类号： G02B5/1852 , B01D25/001 , B01D25/26 , B01D2201/46 , B01J19/0093 , B01J35/04 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/101 , F28D9/00 , F28D9/0037 , F28F2260/02 , Y02W10/15 , Y10T29/49366 , Y10T29/5183 , Y10T82/10 , Y10T82/266
摘要： Un procédé permet de produire des corps à structure fine (15a-15e) ayant une pluralité de canaux adjacents de forme très précise, de dimensions très stables et d'une haute qualité de surface. On forme une pluralité de rainures (3) à section transversale constante et à contour défini sur toute leur longueur par incision de feuilles (1), de préférence métalliques, dont la surface est entaillable. Les feuilles à rainures, ou des feuilles avec et sans rainures sont superposées et reliées. Le procédé décrit permet avec des moyens simples de former dans ces corps à structure fine une pluralité de canaux très rapprochés ayant une section transversale constante sur toute leur longueur, une haute précision et une haute qualité de surface. On peut sélectionner librement dans une large gamme la forme de la section transversale et l'agencement des canaux. Les sections transversales se mesurent par millièmes de millimètres, et l'épaisseur des parois les plus minces de séparation de canaux adjacents se mesure en centièmes de millimètres, les canaux ayant une longueur supérieure à 1000 mum. Les rainures sont usinées par entaillement par des diamants de façonnage, la précision de la forme des rainures, pour ce qui est de leur section transversale, tournant autour de U 1 mum, les plus minces parois ayant environ 15 mum et la longueur des rainures étant supérieure à 1000 mum.
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公开(公告)号：EP0605527A1
公开(公告)日：1994-07-13
申请号：EP92919901.0
申请日：1992-09-23
发明人： WEIBEZAHN, Karl, Friedrich , KNEDLITSCHEK, Gudrun , DERTINGER, Hermann , SCHUBERT, Klaus , BIER, Wilhelm , SCHALLER, Thomas
CPC分类号： B01L3/5085 , C12M23/34 , C12M25/02 , C12M29/04 , C12N5/0068 , C12N2533/30 , C12N2535/10
摘要： Substrat pour cultures de cellules comprenant un corps microstructuré en forme de plaque. Afin d'absorber des cellules ou des agrégats de cellules, ce corps comporte une multiplicité de cavités séparées les unes des autres par des entretoises. Le plus grand diamètre et la profondeur de ces cavités correspondent toujours à un multiple du diamètre des cellules ou des agrégats de cellules. Ces cavités comportent toujours au moins une ouverture au niveau de leur base, qui est inférieure à la plus petite des cellules ou au plus petit des agrégats de cellules à absorber par les cavités. Une culture de cellules se forme également avec ce substrat. Cette invention consiste à proposer un substrat qui permet d'élaborer une culture de cellules en trois dimensions.
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公开(公告)号：EP0391895B1
公开(公告)日：1992-05-13
申请号：EP88902400.6
申请日：1988-03-17
申请人： KERNFORSCHUNGSZENTRUM KARLSRUHE GMBH , Messerschmitt-Bölkow-Blohm Gesellschaft mit beschränkter Haftung
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , SCHMID, Peter , BICHLER, Peter , BRUNNER, Winfried , SIMON, Wolfgang
IPC分类号： B23P15/00
CPC分类号： G02B5/1852 , B01D25/001 , B01D25/26 , B01D2201/46 , B01J19/0093 , B01J35/04 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , B23B1/00 , B23C3/00 , B23P15/26 , C02F3/101 , F28D9/00 , F28D9/0037 , F28F2260/02 , Y02W10/15 , Y10T29/49366 , Y10T29/5183 , Y10T82/10 , Y10T82/266
摘要： A process for manufacturing fine-structured bodies (15a-15e) with several closely spaced channel-like perforations of highly uniform shape, dimensions and surface quality. Several grooves (3) of constant cross-section and given cross-sectional contour over their entire length are cut in the surface of incisable, preferably metallic sheets (1), and grooved or grooved and ungrooved sheets are superimposed and joined together. The process permits the manufacture of fine-structured bodies of this type using simple means to produce a plurality of closely spaced channel-like perforations of constant cross-section and given cross-sectional contour over their entire length in these bodies. The perforations may be of any cross-sectional shape and arrangement, within very wide limits, the dimensional precision of the cross-sections is of the order of a thousandth of a millimetre, and the smallest wall thicknesses between adjacent perforations are of the order of a hundredth of a millimetre for perforations of length greater than 1000 mum. The grooves are cut by diamond tools, so that the dimensional precision of their cross-section is approx. U 1 mum for smallest wall thicknesses of approx. 15 mum and groove lengths of over 1000 mum.
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公开(公告)号：EP0956151B1
公开(公告)日：2003-03-12
申请号：EP98905302.0
申请日：1998-01-16
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , HERRMANN, Erhard , Klinksiek, Bernd , Krumbach, Bernd
CPC分类号： B01J19/0093 , B01J19/2415 , B01J19/26 , B01J2219/00074 , B01J2219/00103 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02
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6.发明授权
公开(公告)号：EP0861121B1
公开(公告)日：1999-07-28
申请号：EP96934816.8
申请日：1996-10-24
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , HERRMANN, Erhard , KOGLIN, Bernd , MENZEL, Thomas
CPC分类号： B01F5/0256 , B01F5/0644 , B01F13/00 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , Y10S366/03
摘要： Described is a method of continuously producing a dispersion of at least one fluid A forming the disperse phase and at least one fluid B forming a continuous phase surrounding the disperse phase. At least one stream of fluid A and at least one stream of fluid B are fed into a dispersion apparatus where they meet in a dispersion chamber. Used is a microchannel dispersion apparatus (1a, 1b, 3a, 3b) in which each of the streams of fluid A and B are divided by an array of microchannels (1a, 1b) into separate threads of moving fluid which emerge into the dispersion chamber (4) with each thread of the same fluid moving at the same speed in such a way that, at the channel outlets, each jet (6a) of disperse phase is immediately adjacent to a jet (6b) of continuous phase and so that each jet (6a) of disperse phase is surrounded, as it breaks up into droplets, by the adjacent jets (6b) of continuous phase.
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7.发明授权
公开(公告)号：EP0758918B1
公开(公告)日：1998-09-09
申请号：EP95919399.6
申请日：1995-05-05
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , SEIDEL, Dieter , MENZEL, Thomas , KOGLIN, Bernd , PREISIGKE, Hans-Joerg , HERRMANN, Erhard
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0093 , B01F13/0096 , B01J19/0093 , B01J19/2415 , B01J2219/00121 , B01J2219/00159 , B01J2219/00783 , B01J2219/00889 , B01J2219/00995 , F28D9/0037 , F28F3/04 , F28F2260/02
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8.发明公开
公开(公告)号：EP0861121A1
公开(公告)日：1998-09-02
申请号：EP96934816.0
申请日：1996-10-24
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , HERRMANN, Erhard , KOGLIN, Bernd , MENZEL, Thomas
CPC分类号： B01F5/0256 , B01F5/0644 , B01F13/00 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , Y10S366/03
摘要： Described is a method of continuously producing a dispersion of at least one fluid A forming the disperse phase and at least one fluid B forming a continuous phase surrounding the disperse phase. At least one stream of fluid A and at least one stream of fluid B are fed into a dispersion apparatus where they meet in a dispersion chamber. Used is a microchannel dispersion apparatus (1a, 1b, 3a, 3b) in which each of the streams of fluid A and B are divided by an array of microchannels (1a, 1b) into separate threads of moving fluid which emerge into the dispersion chamber (4) with each thread of the same fluid moving at the same speed in such a way that, at the channel outlets, each jet (6a) of disperse phase is immediately adjacent to a jet (6b) of continuous phase and so that each jet (6a) of disperse phase is surrounded, as it breaks up into droplets, by the adjacent jets (6b) of continuous phase.
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9.发明公开
公开(公告)号：EP0859660A1
公开(公告)日：1998-08-26
申请号：EP96934817.0
申请日：1996-10-24
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , HERRMANN, Erhard , KOGLIN, Bernd , MENZEL, Thomas , MAUL, Christine
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0094 , B01J19/0093 , B01J19/18 , B01J19/2415 , B01J2219/00085 , B01J2219/00164 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03 , Y10T137/2514 , Y10T137/2516 , Y10T137/2559 , Y10T137/2562 , Y10T137/2564
摘要： Described is a method of carrying out a reaction between at least two reactants (A, B) each of which is divided by an array of slit-shaped microchannels (1a, 1b) into separate laminae of fluid which subsequently emerge into a common mixing and reaction chamber. The laminae of fluid have a thickness of
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10.发明公开
公开(公告)号：EP0758918A1
公开(公告)日：1997-02-26
申请号：EP95919399.0
申请日：1995-05-05
发明人： SCHUBERT, Klaus , BIER, Wilhelm , LINDER, Gerd , SEIDEL, Dieter , MENZEL, Thomas , KOGLIN, Bernd , PREISIGKE, Hans-Joerg , HERRMANN, Erhard
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0093 , B01F13/0096 , B01J19/0093 , B01J19/2415 , B01J2219/00121 , B01J2219/00159 , B01J2219/00783 , B01J2219/00889 , B01J2219/00995 , F28D9/0037 , F28F3/04 , F28F2260/02
摘要： In the proposed reaction process, at least two educts (A, B) are divided by their respective assemblies of microchannels (1a, 1b) into spatially separated fluid filaments. These fluid filaments then enter a common mixing and reaction chamber (4). It is essential that the fluid filaments of the two educts (A, B) are allowed to enter the mixing/reaction chamber (4) as free jets (6a, 6b), each free jet (6a) of an educt (A) being led into the mixing/reaction chamber (4) immediately adjacent to a free jet (6b) of a different educt (B). Adjacent free jets then mix by diffusion and/or turbulence. This system significantly accelerates the mixing process by comparison with conventional reactors, and, with rapid chemical reactions, largely prevents the formation of unwanted by-products and secondary products.
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