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14 条记录 (耗时 0.013 秒)

    Succinic acid compounds
    1.
    发明公开
    Succinic acid compounds 失效
    Bernsteinsäurederivaten。

    公开(公告)号：EP0507534A1

    公开(公告)日：1992-10-07

    申请号：EP92302786.6

    申请日：1992-03-30

    申请人： KISSEI PHARMACEUTICAL CO., LTD.

    发明人： Sato, Fumiyasu ,  Tsubaki, Atsushi ,  Hokari, Hiroshi ,  Tanaka, Nobuyuki ,  Saito, Masaru, Kissei Dai-san Seiyuryo ,  Akahane, Kenji ,  Kobayashi, Michihiro

    IPC分类号： C07D209/08 ,  C07D209/44 ,  C07D217/06 ,  C07D409/06 ,  A61K31/395

    CPC分类号： C07D409/06 ,  C07D209/08 ,  C07D209/44 ,  C07D217/06

    摘要： Succinic acid compounds of the formula:

    wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R 1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.

    摘要翻译： 具有下式的琥珀酸化合物：其中A表示杂环基，3至8元环烷基或苯基，其可以具有一个或多个选自以下的取代基：卤素原子，具有 1至6个碳原子和1至6个碳原子的低级烷氧基; B表示可以具有1或2个不饱和键的双环氨基，条件是B与氮原子上的羰基的碳原子键合; R表示氢原子或彼此结合形成化学键; R 1表示氢原子，碳原子数1〜6的低级烷基或碳原子数7〜10的芳烷基。 当存在不对称碳原子时，其对映异构体和其外消旋混合物; 当存在几何异构体时，每种几何异构体，其异构体，其Z-异构体，其顺式异构体和其反式异构体; 和其药学上可接受的盐，增强胰岛素分泌并具有降血糖活性，因此可用于治疗糖尿病。

    Histidine derivatives as renin inhibitors
    8.
    发明公开
    Histidine derivatives as renin inhibitors 失效
    Histidinderivate ALS Renininhibitoren。

    公开(公告)号：EP0181110A2

    公开(公告)日：1986-05-14

    申请号：EP85307555.4

    申请日：1985-10-18

    申请人： Kissei Pharmaceutical Co Ltd

    发明人： Iizuka, Kinji ,  Kamijo, Tetsuhide ,  Kubota, Tetsuhiro ,  Akahane, Kenji ,  Umeyama, Hideaki ,  Kiso, Yoshiaki

    IPC分类号： C07K5/06 ,  C07D233/64 ,  C07D403/02 ,  A61K37/02 ,  A61K31/415

    CPC分类号： C07D233/64 ,  C07C51/487 ,  C07C57/38 ,  C07C57/40 ,  C07C59/66 ,  C07C59/68 ,  C07C65/34 ,  C07D209/18 ,  C07K5/06147 ,  Y10S530/86

    摘要： @ Dipeptides are described which are represented by the formula

    wherein His represents an L-histidyl group, Ar, represents a phenyl group, a naphthyl group or an indolyl group, Ar 2 represents a phenyl group or a naphthyl group, X represents a chemical bond, -NHCO-, -CONH-, -CO-, -CH 2 -, -NH-, -O- or -(CH=CH) P -wherein p is 1 or 2, Z represents an oxygen atom or
    in which R 2 represents a hydrogen atom or combines with R, to form a chemical bond, m and n, which may be the same or different, each represents an integer of from 0 to 3, provided that when X is a chemical bond, the sum of n plus m is from 1 to 6 and when X is not a chemical bond, the sum of n plus m is from 1 to 4, Y represents a chemical bond when X is not a chemical bond, or, when X is a chemical bond, an alkylene group having 1 to 3 carbon atoms, R 1 represents a hydrogen atom or combines with R 2 to form a chemical bond, R 3 represents a formyl group or a hydroxymethyl group, R 4 represents an isobutyl group or a benzyl group, and C represents an L-configurational carbon atom; or the pharmaceutically acceptable salt thereof.
    These compounds have a strong inhibitory effect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin - associated hypertension.

    Histidine derivatives as renin inhibitors
    10.
    发明公开
    Histidine derivatives as renin inhibitors 失效
    作为RENIN抑制剂的HISTIDINE DERIVATIVES

    公开(公告)号：EP0181110A3

    公开(公告)日：1988-05-11

    申请号：EP85307555

    申请日：1985-10-18

    申请人： Kissei Pharmaceutical Co Ltd

    发明人： Iizuka, Kinji ,  Kamijo, Tetsuhide ,  Kubota, Tetsuhiro ,  Akahane, Kenji ,  Umeyama, Hideaki ,  Kiso, Yoshiaki

    IPC分类号： C07K05/06 ,  C07D233/64 ,  C07D403/02 ,  A61K37/02 ,  A61K31/415

    CPC分类号： C07D233/64 ,  C07C51/487 ,  C07C57/38 ,  C07C57/40 ,  C07C59/66 ,  C07C59/68 ,  C07C65/34 ,  C07D209/18 ,  C07K5/06147 ,  Y10S530/86

    摘要： @ Dipeptides are described which are represented by the formula

    wherein His represents an L-histidyl group, Ar, represents a phenyl group, a naphthyl group or an indolyl group, Ar 2 represents a phenyl group or a naphthyl group, X represents a chemical bond, -NHCO-, -CONH-, -CO-, -CH 2 -, -NH-, -O- or -(CH=CH) P -wherein p is 1 or 2, Z represents an oxygen atom or
    in which R 2 represents a hydrogen atom or combines with R, to form a chemical bond, m and n, which may be the same or different, each represents an integer of from 0 to 3, provided that when X is a chemical bond, the sum of n plus m is from 1 to 6 and when X is not a chemical bond, the sum of n plus m is from 1 to 4, Y represents a chemical bond when X is not a chemical bond, or, when X is a chemical bond, an alkylene group having 1 to 3 carbon atoms, R 1 represents a hydrogen atom or combines with R 2 to form a chemical bond, R 3 represents a formyl group or a hydroxymethyl group, R 4 represents an isobutyl group or a benzyl group, and C represents an L-configurational carbon atom; or the pharmaceutically acceptable salt thereof. These compounds have a strong inhibitory effect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin - associated hypertension.