-
公开(公告)号：EP1881852A2
公开(公告)日：2008-01-30
申请号：EP06727994.3
申请日：2006-04-21
IPC分类号： A61K49/12
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
-
2.发明公开CONDUCTIVE STRUCTURE BASED ON POLY-3,4-ALKENEDIOXYTHIOPHENE (PEDOT) AND POLYSTYRENESULFONIC ACID (PSS) 有权导报基于poly-3,4-ALKENDIOXYTHIOPHEN（PEDOT）结构与聚苯乙烯（PSS）
公开(公告)号：EP1138091A1
公开(公告)日：2001-10-04
申请号：EP00962444.6
申请日：2000-09-06
发明人： DE LEEUW, Dagobert, M. , GELINCK, Gerwin, H. , TOUWSLAGER, Fredericus, J. , WILLARD, Nicolaas, P.
CPC分类号： H01L51/0037 , G03F7/0125 , G03F7/038 , G03F7/093 , H01B1/127 , H01G11/48 , H01L27/3239 , H01L51/0014 , H01L51/0021 , H01L51/0023 , H01L51/0036 , H01L51/0516 , H01L51/0541 , H01L51/5088 , H01L51/5206 , Y02E60/13
摘要： An electronic component has an electrically conductive relief structure (3) which contains a salt of a poly-3,4-alkylenedioxythiophene. This salt provides the structure with a stable conductivity. The salt is a polyacid salt by preference. The polyacid salt of poly-3,4-alkylenedioxythiophene is used in the method of manufacturing a relief structure on an electrically insulating substrate. Relief structures (3) comprising tracks (311-314, 321-324) and channels (141) with track widths (tW) and channel lengths (cL) of less than 10 νm can be achieved. The tracks (311-314; 321-324) are used as electrodes (31; 32), the channels (141) are used as semiconductor channels in electronic components, especially in fieldeffect transistors (11) and light-emitting diodes.
-
公开(公告)号：EP1824521A2
公开(公告)日：2007-08-29
申请号：EP05804156.7
申请日：2005-11-15
IPC分类号： A61K49/00
CPC分类号： A61K49/225 , A61K47/6907 , A61K47/6923 , A61K47/6929 , A61K47/6941 , B82Y5/00
摘要： A new type of contrast agent is described, which comprises matrix particles with a plurality of metal nanoparticles as well as the method of imaging therewith. A plurality of metal nanoparticles are encapsulated in a non-proteinaceous biocompatible or biodegradable matrix particle and/or attached to a non-proteinaceous biocompatible or biodegradable matrix particle, the matrix of the matrix particles being selected from the group consisting of a carbohydrate, a lipid, a synthetic polymer, an aqueous liquid, a surfactant and an organic liquid, or a mixture thereof. The matrix particles are biocompatible and/or biodegradable and can be coupled to targeting molecules for targeted visualization.
-
4.发明授权FULL-COLOR ELECTROCHROMIC DISPLAY WITH STACKED IN CELL MONOCHROMIC ELECTROCHROMES 有权相互有关存储电致变色层色的电致变色显示
公开(公告)号：EP1532483B1
公开(公告)日：2006-09-27
申请号：EP03740939.8
申请日：2003-07-01
CPC分类号： G09G3/38 , G02F1/15 , G02F1/155 , G02F2001/1515 , G09G2300/0809 , G09G2340/16
摘要： A display device comprising a plurality of independently addressable pixels (1) comprising: a first substrate (2); a counter-electrode (3); a second substrate (4); a stack of electrochromic layers (5a, 5b, 5c) associated with said second substrate (4); an electrolyte (6) disposed between said counter-electrode (3) and said stack of electrochromic layers (5a, 5b, 5c). Said electrochromic layers (5a, 5b, 5c) are each independently addressable for switching operation; and separated from each other by layers of an electrolyte (7). A driving method for operating said pixel (1) comprises the steps of: providing at least one power line (8) which is selectively connectable to an electrochromic layer (5) or a working electrode (10) associated with said electrochromic layer (5); selectively applying to said power line (8) a bleaching or coloring voltage; addressing the electrochromic layer (5) which is to be bleached or colored; connecting said power line (8) to said addressed electrochromic layer (5); retaining the connection of said power line (8) during a hold period; and disconnecting said power line (8).
-
公开(公告)号：EP2162065A1
公开(公告)日：2010-03-17
申请号：EP08763418.4
申请日：2008-06-23
发明人： VAN KESTEREN, Hans, W. , VINK, Teunis, J. , WILLARD, Nicolaas, P. , KALKMAN, Jeroen , SAALMINK, Milan
IPC分类号： A61B5/08 , G01N33/497 , G01N21/17
CPC分类号： G01N33/497 , A61B5/087 , A61B5/411 , G01N21/1702
摘要： A device (100) for measuring a concentration of NO in exhaled air is provided. The device (100) comprises a mouthpiece (11), an NO sensor (12), an airway obstruction measurement and an analysis module. The mouthpiece (11) receives the exhaled air during an exhalation. The NO sensor (12) measures the concentration of NO in the exhaled air. The airway obstruction measurement module determines an airway obstruction parameter. The analysis module (16) analyzes an inflammatory status of a respiratory system based on a combination of the measured concentration of NO and the determined airway obstruction parameter.
-
公开(公告)号：EP1889086A2
公开(公告)日：2008-02-20
申请号：EP06727996.8
申请日：2006-04-21
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , G01R33/4804
摘要： The invention relates to a method for mapping of a physico-chemical parameter such as pH, temperature, pO2 or metabolite concentration using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method is a modification of the known ratiometric method and may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
-
公开(公告)号：EP1877813A2
公开(公告)日：2008-01-16
申请号：EP06728040.4
申请日：2006-04-25
发明人： WILLARD, Nicolaas, P. , WEGH, Rene, T. , PIKKEMAAT, Jeroen, A. , GRUELL, Holger , SCHAEFFTER, Tobias , LAMERICHS, Rudolf, M., J., N.
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method of MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent such as a CEST contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts .
-
公开(公告)号：EP1700331A1
公开(公告)日：2006-09-13
申请号：EP04801483.1
申请日：2004-12-07
IPC分类号： H01L21/02 , H01L21/312 , H01L21/311
CPC分类号： H01L21/0212 , H01L21/02282 , H01L21/02348 , H01L21/28291 , H01L21/31133 , H01L21/3127 , H01L27/11507 , H01L28/55
摘要： Ferroelectric polymers such as for example copolymers of vinylidenedifluoride (VDF) and trifluoroethylene (TrFE) may be patterned by spincoating the ferroelectric polymer layer from a ferroelectric spincoating solution, which comprises a photosensitive crosslinker, onto a substrate followed by irradiating the ferroelectric polymer layer through a mask and removing the unexposed parts of the ferroelectric polymer layer.
-
公开(公告)号：EP1534463B1
公开(公告)日：2006-03-29
申请号：EP03792540.1
申请日：2003-07-18
发明人： BRZESOWSKY, Rudolf, H. , BALKENENDE, Abraham, R. , VAN AGTHOVEN, Raymond, G., A. , TIMMERMANS, Petrus, H., M. , WILLARD, Nicolaas, P.
IPC分类号： B23K26/14 , C03B33/09 , C03B33/095
CPC分类号： B23K26/073 , B23K26/146 , B23K26/40 , B23K2201/40 , B23K2203/50 , B23K2203/52 , B28D5/0011 , C03B33/091 , Y10T225/12 , Y10T225/304
摘要： The invention relates to a method of breaking a substrate of a brittle material, the method comprising the steps of providing a substrate (1) of a brittle material, heating the substrate with a laser beam (3) to create a heated spot on the substrate, moving the laser beam and the substrate with respect to each other to create a line of heated spots on the substrate (2), cooling the heated spots on the substrate by locally applying a cooling medium (4) behind the heated spots such that a micro-crack is propagated in the line of heated spots, and breaking the substrate along the line of the propagated micro-cracks by applying a mechanical force on the substrate wherein, the cooling medium comprises an aqueous surfactant solution. The surfactants will connect to the broken siloxane bonds inside the surface cracks. Then recombination and healing of the broken siloxane bonds will not occur and the required breaking load will remain constant over time.
-
公开(公告)号：EP1881852B1
公开(公告)日：2009-08-19
申请号：EP06727994.3
申请日：2006-04-21
IPC分类号： A61K49/12
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.016 秒)
