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    GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS
    5.
    发明公开
    GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS 审中-实审

    公开(公告)号：EP4368993A2

    公开(公告)日：2024-05-15

    申请号：EP24160209.3

    申请日：2019-04-10

    申请人： Koninklijke Philips N.V.

    发明人： KOOIJMAN, Gerben ,  RMAILE, Amir Hussein ,  GLASSE, Carl ,  DE JAGER, Marinus Karel Johannes ,  CHAPPLE, Iain Leslie Campbell ,  GRANT, Melissa Mackay ,  PRESHAW, Philip ,  TAYLOR, John ,  VAN HARTSKAMP, Michael Alex

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2800/1820130101

    摘要： Disclosed is an in vitro method for assessing whether a human patient has gingivitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from gingivitis, the concentrations are measured of the certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and S100 calcium-binding protein A8 (S100A8), and at least one of Hemoglobin subunit beta (Hb-beta), Keratin 4 (K-4) and Pyruvate Kinase (PK). Another combination is Alpha-1-acid glycoprotein (A1AGP), Hemoglobin subunit beta (Hb-beta) and Keratin 4 (K-4). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with gingivitis. The comparison allows assessing whether the testing value is indicative of the presence of gingivitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of gingivitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for gingivitis in said patient.

    PERIODONTITIS DIAGNOSTIC METHODS, USES AND KITS
    8.
    发明公开
    PERIODONTITIS DIAGNOSTIC METHODS, USES AND KITS 审中-公开

    公开(公告)号：EP3553518A1

    公开(公告)日：2019-10-16

    申请号：EP18166975.5

    申请日：2018-04-12

    申请人： Koninklijke Philips N.V.

    发明人： KOOIJMAN, Gerben ,  RMAILE, Amir Hussein ,  GLASSE, Carl ,  DE JAGER, Marinus Karel Johannes ,  CHAPPLE, Iain Leslie Campbell ,  GRANT, Melissa Mackay ,  PRESHAW, Philip ,  TAYLOR, John ,  VAN HARTSKAMP, Michael Alex

    IPC分类号： G01N33/573 ,  G01N33/68 ,  G06F19/10 ,  G16H50/30

    摘要： Disclosed is an in vitro method for assessing whether a human patient has periodontitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of two or more of the proteins Matrix metalloproteinase-8 (MMP-8), Matrix metalloproteinase-9 (MMP-9), Pyruvate Kinase (PK) and S100 calcium-binding protein A8 (S100A8). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for periodontitis in said patient.