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    ANALYSIS OF SALIVA PROTEOME FOR BIOMARKERS OF GINGIVITIS AND PERIODONTITIS USING FT-ICR-MS/MS
    2.
    发明公开
    ANALYSIS OF SALIVA PROTEOME FOR BIOMARKERS OF GINGIVITIS AND PERIODONTITIS USING FT-ICR-MS/MS 审中-公开

    公开(公告)号：EP3396383A1

    公开(公告)日：2018-10-31

    申请号：EP18173015.1

    申请日：2013-09-10

    申请人： Koninklijke Philips N.V.

    发明人： CHAPPLE, Iain ,  CREESE, Andrew ,  GRANT, Melissa

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6848 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2800/18

    摘要： Methods for diagnosing the status of periodontitis disease includes selecting a set of protein biomarkers including one or more biomarkers which have been shown to vary in abundance at particular stages of periodontitis. The set of protein biomarkers may be identified and quantified in expression in an acquired gingival crevicular fluid (GCF) or saliva oral fluid sample in order to distinguish between different states of periodontitis. Methods of diagnosing the status of periodontitis oral disease at varying levels of severity, e.g. gingivitis, mild periodontitis, or severe periodontitis, may include selecting a set of protein biomarkers which are capable distinguishing between different stages of periodontitis.

    TEST KIT FOR PLASMA OR SERUM ANTIBODY TITER AGAINST PERIODONTAL DISEASE-CAUSING BACTERIA
    3.
    发明授权
    TEST KIT FOR PLASMA OR SERUM ANTIBODY TITER AGAINST PERIODONTAL DISEASE-CAUSING BACTERIA 有权

    公开(公告)号：EP3139167B1

    公开(公告)日：2018-09-26

    申请号：EP16190674.8

    申请日：2011-10-18

    申请人： Sunstar Inc.

    发明人： NOZOE, Mikio

    IPC分类号： G01N33/569 ,  C07K14/195 ,  C12N15/09 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  C07K14/195 ,  G01N33/54366 ,  G01N33/56955 ,  G01N33/6854 ,  G01N2800/18 ,  Y10S435/81

    摘要： The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be treated by an automated device at a high speed; a periodontal disease-causing bacterium antigen protein which can be suitably used in the kit; a method for testing an antibody titer or the presence of an antibody in a blood sample using the kit; and a kit for typing strains of Porphyromonas gingivalis. The present invention discloses: a test kit comprising a set of polypeptides respectively having the acid sequences represented by SEQ ID NOs: 1, 3, 9, 15, 19, 31, 41, 43, 63, 65 and 67; a modified polypeptide having the amino acid sequence represented by SEQ ID NO: 67; and a method for determining an antibody titer or the presence of an antibody against a periodontal disease-causing bacterium in a blood sample separated from a human body, comprising bringing the blood sample into contact with the above-mentioned set of polypeptides.

    GUM CONDITION ASSESSMENT
    5.
    发明公开
    GUM CONDITION ASSESSMENT 审中-公开
    口香糖状况评估

    公开(公告)号：EP3232985A1

    公开(公告)日：2017-10-25

    申请号：EP15869117.0

    申请日：2015-10-20

    申请人： The Procter & Gamble Company

    发明人： CHANG, Jinlan ,  ZHANG, Wendi ,  HE, Yanyan ,  TANG, Ying ,  HE, Tao

    IPC分类号： A61C19/04

    CPC分类号： G01N21/33 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/14535 ,  A61B10/0051 ,  G01N33/72 ,  G01N2800/18

    摘要： A method of assessing a gum condition of an individual is provided, which comprising the steps: (a) tooth brushing within an oral cavity of the subject individual; (b) post-brushing rinsing the brushed oral cavity with a post-brushing rinse solution comprising volume from 1ml to 50 ml, for a predetermined post-brushing rinsing time, wherein the predetermined post-rinsing time is from 1second to 1 minute; (c) collecting expectorated post-brushing rinse solution from the subject individual; (d) measuring hemoglobin quantity contained in the collected post-brushing rinse solution; (e) comparing the measured hemoglobin quantity against a known standard of gum conditions corresponding to hemoglobin quantities to assess the gum condition of the subject individual from the compared hemoglobin quantities.

    摘要翻译： 提供了评估个体牙龈状况的方法，其包括以下步骤：（a）在受试者个体的口腔内刷牙; （b）刷后用含有1ml至50ml体积的刷后冲洗溶液冲洗刷过的口腔，持续预定的刷洗后冲洗时间，其中预定的冲洗后时间为1秒至1分钟; （c）从受试者收集预期的刷牙后冲洗液; （d）测量所收集的刷洗后冲洗溶液中含有的血红蛋白量; （e）将测量​​的血红蛋白量与相应于血红蛋白量的已知口香糖状况标准进行比较，以从所比较的血红蛋白量评估受试者个体的牙龈状况。

    IN-VITRO METHOD AND KIT FOR DIAGNOSING THE RISK OF SUFFERING FROM CARIES
    6.
    发明公开
    IN-VITRO METHOD AND KIT FOR DIAGNOSING THE RISK OF SUFFERING FROM CARIES 审中-公开
    用于诊断罹患龋病风险的体内方法和试剂盒

    公开(公告)号：EP3229020A1

    公开(公告)日：2017-10-11

    申请号：EP15862543.4

    申请日：2015-11-27

    申请人： Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

    发明人： MIRA OBRADOR, Alejandro ,  SIMÓN SORO, Áurea

    IPC分类号： G01N33/487 ,  G01N33/52 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/18 ,  G01N2800/60

    摘要： The invention describes a method of predicting the risk of caries in a subject and a kit based on said method, characterized in that the method involves the following steps:
    (a) determining the concentration in the saliva of the subject of: (i) at least one compound selected from among the components of the saliva of the immune system; (ii) at least one compound selected from among those involved in microbial adhesion to a surface of the buccal cavity; and (iii) at least one compound selected from among the components involved in the metabolism or regulation of pH in the buccal cavity;
    (b) comparing a response variable calculated on the basis of the at least one of the concentrations determined in (i), at least one of the concentrations determined in (ii), and at least one of the concentrations determined in (iii) in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
    (c) determining the risk of caries on the basis of the degree of difference in the response variable compared in step (b), wherein a higher degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries is indicative of a higher risk of caries in said subject.

    摘要翻译： 本发明描述了基于所述方法预测受试者中龋齿风险的方法和试剂盒，其特征在于该方法包括以下步骤：（a）确定受试者唾液中的浓度：（i）在 选自免疫系统唾液组分中的至少一种化合物; （ii）至少一种选自微生物粘附到颊腔表面的化合物; 和（iii）至少一种选自参与代谢或调节颊腔pH值的成分的化合物; （b）比较基于（i）中确定的至少一种浓度，（ii）中确定的至少一种浓度和（iii）中确定的至少一种浓度计算的响应变量 步骤（a）在具有龋齿的受试者群体中或在具有龋齿的受试者群体中具有相应的参考响应变量; 和（c）基于步骤（b）中比较的响应变量的差异程度确定龋齿风险，其中所述受试者的响应变量与群体中的相应参考响应变量之间的较高程度的差异 没有龋齿的受试者或龋齿受试者群体表明所述受试者龋齿的风险较高。

    Diagnostic prediction of caries risk by saliva marker analysis
    8.
    发明公开
    Diagnostic prediction of caries risk by saliva marker analysis 审中-公开
    Diagnostische Prognose des Kariesrisikos mittels Speichelmarkeranalyse

    公开(公告)号：EP3026435A1

    公开(公告)日：2016-06-01

    申请号：EP14195383.6

    申请日：2014-11-28

    申请人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana

    发明人： Mira Obrador, Alejandro ,  Soro Áurea, Simón

    IPC分类号： G01N33/68 ,  G01N33/84

    CPC分类号： G01N33/6893 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/18 ,  G01N2800/60

    摘要： The present invention discloses a method for predicting caries risk in a subject and a kit based on said method, characterized in that said method comprises:
    (a) determining the concentration in saliva from said subject of at least one compound selected from each of salivary components (i) of the immune system, (ii) involved in microbial adhesion to a surface of the buccal cavity; and (iii) involved in metabolism in the buccal cavity or in regulating the pH thereof;
    (b) comparing a response variable calculated from more than one concentration determined in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
    (c) determining caries risk based on the degree of difference in response variable compared in step (b), wherein a greater degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries, is indicative of higher caries risk in said subject.

    摘要翻译： 本发明公开了一种基于所述方法预测受试者和试剂盒的龋齿风险的方法，其特征在于所述方法包括：（a）确定所述受试者的唾液中至少一种选自唾液成分中的每种化合物的浓度 （i）免疫系统，（ii）涉及到颊腔表面的微生物粘附; 和（iii）参与颊腔中的代谢或调节其pH值; （b）将在步骤（a）中确定的多于一种浓度的反应变量与在不具有龋齿的受试者群体中的相应参考响应变量进行比较; 和（c）基于在步骤（b）中比较的响应变量的差异程度来确定龋齿风险，其中所述受试者的反应变量与没有龋齿的受试者群体中的相应参考响应变量之间的较大程度的差异 在具有龋齿的受试者群体中，表明所述受试者的龋齿风险较高。