公开(公告)号：EP2038651B1

公开(公告)日：2017-03-29

申请号：EP07735881.0

申请日：2007-05-14

申请人： Koninklijke Philips N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  VOSSENAAR, Erik Robert ,  SPEKOWIUS, Gerhard ,  VAN DER VAART, Nijs Cornelis ,  KUIPER, Stein

IPC分类号： G01N33/53 ,  G01N33/50 ,  G01N33/58 ,  G01N33/574 ,  C12Q1/68 ,  G01N33/487 ,  G06T7/00 ,  G01N15/14 ,  G01N21/33 ,  G06T7/40 ,  G06K9/00

CPC分类号： G01N33/582 ,  C12Q1/68 ,  G01N15/147 ,  G01N21/33 ,  G01N33/5035 ,  G01N33/5076 ,  G01N33/5308 ,  G01N33/574 ,  G06K9/00134 ,  G06T7/0012 ,  G06T7/41 ,  G06T2207/10056 ,  G06T2207/30024 ,  C12Q2523/313

公开(公告)号：EP2046188B1

公开(公告)日：2019-03-27

申请号：EP07735484.3

申请日：2007-04-12

申请人： Philips Intellectual Property & Standards GmbH

发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  KUHN, Michael Harald ,  ZAENGEL, Thomas ,  VAN DER VAART, Nijs Cornelis

IPC分类号： A61B1/04 ,  A61B1/06

公开(公告)号：EP2046188A1

公开(公告)日：2009-04-15

申请号：EP07735484.3

申请日：2007-04-12

申请人： Philips Intellectual Property & Standards GmbH

发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  KUHN, Michael Harald ,  ZAENGEL, Thomas ,  VAN DER VAART, Nijs Cornelis

IPC分类号： A61B1/04 ,  A61B1/06

CPC分类号： A61B1/00087 ,  A61B1/00165 ,  A61B1/00188 ,  A61B1/0019 ,  A61B1/041 ,  A61B1/042 ,  A61B1/043 ,  A61B1/06 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0084 ,  A61B18/20 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609 ,  G03B15/02

摘要： The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas, —a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

公开(公告)号：EP2059786A2

公开(公告)日：2009-05-20

申请号：EP07805115.8

申请日：2007-07-11

申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  DE BOER, Ruth Wilhelmine Ireen ,  SPEKOWIUS, Gerhard ,  KUIPER, Stein ,  VAN DER VAART, Nijs Cornelis

IPC分类号： G01N15/14 ,  C12Q1/68 ,  G01N21/64

CPC分类号： G01N21/33 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/6852 ,  G01N15/1475 ,  G01N21/6458

摘要： The invention relates to a method of determining in vivo in a human or animal subject the amount of nuclear DNA by first localizing cell nuclei of living tissue and subsequently measuring the nuclear UV absorbance using confocal scanning microscopy. The invention relates also to a method for detecting cancerous cells in vivo in a human or animal subject by first identifying the localization of cell nuclei in living tissue and subsequently determining the nuclear UV absorbance by laser scanning confocal microscopy. Furthermore, the invention relates to a method of diagnosing cancer in a human or animal subject in vivo relying on a combination of identifying the localization of cell nuclei in living tissue and measuring nuclear UV absorbance by laser scanning confocal microscopy.

公开(公告)号：EP2038651A2

公开(公告)日：2009-03-25

申请号：EP07735881.0

申请日：2007-05-14

申请人： Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus ,  VOSSENAAR, Erik Robert ,  SPEKOWIUS, Gerhard ,  VAN DER VAART, Nijs Cornelis ,  KUIPER, Stein

IPC分类号： G01N33/53 ,  G01N33/50 ,  G01N33/58 ,  G01N33/574 ,  C12Q1/68 ,  G01N33/487 ,  G06T7/00 ,  G01N15/14

CPC分类号： G01N33/582 ,  C12Q1/68 ,  G01N15/147 ,  G01N21/33 ,  G01N33/5035 ,  G01N33/5076 ,  G01N33/5308 ,  G01N33/574 ,  G06K9/00134 ,  G06T7/0012 ,  G06T7/41 ,  G06T2207/10056 ,  G06T2207/30024 ,  C12Q2523/313

摘要： The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject.

摘要翻译： 本发明涉及确定的采矿的方法在体外核DNA的量使用UV吸收测量用UV光的人或动物细胞内。 因此本发明涉及一种用于生物样品依靠上述原则中检测癌细胞在体外的方法。 因此，本发明涉及体外诊断或预测在人或动物对象的癌症可能发生的方法。

公开(公告)号：EP4289341A1

公开(公告)日：2023-12-13

申请号：EP22178123.0

申请日：2022-06-09

申请人： Koninklijke Philips N.V.

发明人： RONDA, Cornelis Reinder ,  PEKAR, Martin ,  HENDRIKS, Bernardus Hendrikus Wilhelmus ,  PRESURA, Christian Nicolae ,  RMAILE, Amir Hussein ,  HOETZL, Sandra ,  PAULUSSEN, Igor Wilhelmus Franciscus ,  BORN, Matthias

IPC分类号： A61B5/00

摘要： A device and method for providing a classification of tooth surface materials using measured reflectance values for light within a particular optical band. In particular, at least two optical reflectance measurements may obtained within an optical wavelength band of 550 nm to 650 nm, and wherein a characteristic value proportional to a difference or ratio of those measurements is computed. This provides an indication, direct or indirect, of a sign of a slope of a reflectance spectrum within that band, and this has been identified through experiment as a reliable differentiator of healthy vs unhealthy enamel (presence of caries vs absence of caries).

公开(公告)号：EP4198998A1

公开(公告)日：2023-06-21

申请号：EP21215664.0

申请日：2021-12-17

申请人： Koninklijke Philips N.V.

发明人： WILDEBOER, Rogier Rudolf ,  RUETTEN, Walter ,  KOLEN, Alexander ,  CLUITMANS, Matthijs Joseph Maria ,  HENDRIKS, Bernardus Hendrikus Wilhelmus ,  KAHLMAN, Josephus Arnoldus Johannes Maria

IPC分类号： G16H30/40 ,  G16H40/63 ,  G16H50/50

摘要： A mechanism for identifying regions of an anatomical element that are insufficiently represented by the anatomical model and/or are sites of a local structural or electrical abnormality. An anatomical model and a measured electrical activity model are obtained. The anatomical model is processed to produce a predicted electrical activity model. The measured and predicted electrical activity models are compared to identify any regions of mismatch, which represent regions underrepresented by the anatomical model and/or sites of abnormalities.

公开(公告)号：EP4190222A1

公开(公告)日：2023-06-07

申请号：EP21211769.1

申请日：2021-12-01

申请人： Koninklijke Philips N.V.

发明人： PAULUSSEN, Elvira Johanna Maria ,  LAI, Marco ,  HENDRIKS, Bernardus Hendrikus Wilhelmus ,  REICH, Christian ,  COMPEN, Hendrikus Antonius Cornelus Maria ,  SHAN, Caifeng

IPC分类号： A61B1/00

摘要： An endoscope system is for generating an image of tissue to be examined. The system is adapted to deliver radiation with a first polarization to the tissue, and a return polarization control system is provided in the path between the tissue and the receiver. It has an electrically controllable adjuster with an array of adjuster pixels which are independently controllable to implement a local polarization control in respect of local regions of the image. In this way, the image can be enhanced in a pixelated way to give the best possible imaging of tissue beneath the surface.

公开(公告)号：EP4023182A1

公开(公告)日：2022-07-06

申请号：EP20218002.2

申请日：2020-12-31

申请人： Koninklijke Philips N.V.

发明人： WILDEBOER, Rogier Rudolf ,  HENDRIKS, Bernardus Hendrikus Wilhelmus ,  JANSSEN, Rik Jozef Martinus ,  SCHÄFER, Dirk

IPC分类号： A61B34/20

摘要： A mechanism for generating a mapping function for mapping measurements taken at an electrode within crossing electric fields to a position or positions within a multidimensional co-ordinate system. The values for coefficients of the mapping function are generated using a first machine-learning algorithm, which receives, as input, example measurements (or responses) of the electrode and provides, as output, values for the coefficients for the mapping function. There is proposed a method and processing system for carrying out this mechanism.

公开(公告)号：EP3789754A1

公开(公告)日：2021-03-10

申请号：EP20198404.4

申请日：2015-03-13

申请人： Koninklijke Philips N.V.

发明人： WIJBRANS, Klaas Cornelis Jan ,  LUCASSEN, Gerhardus Wilhelmus ,  HENDRIKS, Bernardus Hendrikus Wilhelmus

IPC分类号： G01N21/25 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01J3/02 ,  G01J3/36 ,  A61B5/00 ,  G01J3/12

摘要： A spectroscopic analysis device for analysis of a sample comprising:
a photonic integrated circuit (PIC) comprising:
an input (DEF) for receiving light from the sample; and
a demultiplexer (DEMUX) arranged to distribute the received light into at least a first optical chain (C1) and a second optical chain (C2);
wherein each optical chain (C1, C2) of the photonic integrated circuit (PIC) further comprises a tunable bandpass filter (TBF1, TBF2) and a photodetector (PD1, PD2) arranged respectively to filter and to detect the light distributed into its corresponding optical chain (C1, C2);
wherein each optical chain (C1, C2) further comprises an integrator (INT1, INT2) configured to integrate an electrical output of the photodetector in its corresponding optical chain (C1, C2);
wherein i) each tunable bandpass filter (TBF1, TBF2) is configured to receive control data indicative of a time period (T Filter ) during which the corresponding tunable bandpass filter (TBF1, TBF2) is arranged to filter a predetermined wavelength interval and/or ii) each integrator (INT1, INT2) is configured to receive control data indicative of a time period (T int ) during which the corresponding integrator is arranged to integrate an electrical output of its corresponding photodetector (PD1, PD2), such that the integration result of the corresponding integrator (INT1, INT2) is controlled based on the respective time period (T Filter , T int ).