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    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS AND ANGIOEDEMA, CONTAINING NATURAL MIXTURE EXTRACT AS ACTIVE INGREDIENT
    3.
    发明公开
    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETIC COMPLICATIONS AND ANGIOEDEMA, CONTAINING NATURAL MIXTURE EXTRACT AS ACTIVE INGREDIENT 审中-公开
    用于预防的药物组合物和糖尿病并发症与天然混合提取物作为积极治疗和血管性水肿

    公开(公告)号：EP3146976A1

    公开(公告)日：2017-03-29

    申请号：EP15796502.1

    申请日：2015-05-21

    申请人： Korea Institute of Oriental Medicine

    发明人： KIM, Jin Sook ,  KIM, Junghyun ,  KIM, Chan-Sik ,  SHON, Eunjin ,  LEE, Yun Mi ,  CHOI, Sojin ,  LEE, Ik Soo ,  KIM, Young Sook ,  JUNG, Dong Ho ,  PYUN, Bo-Jeong ,  JUNG, Seung-Hyun

    IPC分类号： A61K36/54 ,  A61P3/10 ,  A61P3/00 ,  A61K36/65 ,  A61P9/00 ,  A61P35/00

    CPC分类号： A61K36/65 ,  A61K36/54

    摘要： The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy, and angioedema, including macular (retinal) edema, macular degeneration, and varicose veins.

    摘要翻译： 桂枝和牡丹皮根皮，桂枝和白芍，或桂枝和茯苓雅丁到本发明的混合物的提取物已被证实抑制过度生成的高级糖基化终产物，其中慢性糖尿病的条件下发生 表现出片段化的晚期糖基化终产物和基质蛋白之间的交联的效果，具有优异的效果，抑制在经受高血糖或老化的人视网膜色素上皮细胞株的晚期糖基化终产物的生成 环境，并具备在延迟优异的效果，预防和治疗糖尿病并发症，肌肉退化，震荡视网膜，和糖尿病并发症，黄斑变性的各种动物模型中下肢水肿，和下肢水肿，因此混合物提取物可有效地 用作活性成分为一种组合物用于预防和治疗糖尿病complicati 附加组件，包括糖尿病性视网膜病，糖尿病性肾病和糖尿病性神经病变，血管性水肿，包括黄斑（视网膜）水肿，黄斑变性，和静脉曲张。

    EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME
    7.
    发明公开
    EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 有权
    FROM ASTER红松提取物和含有药物组合物和功能性食品

    公开(公告)号：EP2131850A1

    公开(公告)日：2009-12-16

    申请号：EP08723329.2

    申请日：2008-03-07

    申请人： Korea Institute of Oriental Medicine

    发明人： KIM, Jin Sook ,  JANG, Dae Sik ,  LEE, Yun Mi ,  KIM, Jong Min ,  KIM, Young Sook ,  SHON, Eun Jin ,  KIM, Chan Sik ,  KIM, Jung Hyun ,  KIM, Ohn Soon ,  JUNG, Dong Ho ,  YOO, Jeong Lim ,  KIM, Joo Hwan

    IPC分类号： A61K36/28

    CPC分类号： A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

    摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.