公开(公告)号：EP2944316A1

公开(公告)日：2015-11-18

申请号：EP14737578.6

申请日：2014-01-10

申请人： Korea Institute Of Oriental Medicine

发明人： KIM, Jin Sook ,  KIM, Jung Hyun ,  KIM, Chan Sik ,  KIM, Young Sook ,  SHON, Eun Jin ,  LEE, Yun Mi ,  JUNG, Dong Ho ,  LEE, Ik Soo ,  JO, Gyu Hyeong ,  KIM, Joo Hwan

IPC分类号： A61K36/25 ,  A61K36/718 ,  A61P3/00 ,  A61P9/00

CPC分类号： A61K36/25 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/155 ,  A61K36/16 ,  A61K36/45 ,  A61K36/482 ,  A61K36/488 ,  A61K36/708 ,  A61K36/718 ,  A61K36/73 ,  A61K36/87 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum , Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.

摘要翻译： 本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿含常春藤叶和黄连的混合提取物作为活性成分的的改善的健康功能食品组合物。 更具体地，本发明涉及一种药物组合物和用于预防，治疗或糖尿病并发症或血管性水肿还含有的改善，基数在掌叶大黄葛根，银杏叶，决明子，蓝莓，覆盆子，覆盆子提取物的健康功能食品组合物 或葡萄籽作为活性成分的，除了常春藤叶和黄连的混合提取物。

公开(公告)号：EP2131850B1

公开(公告)日：2015-04-29

申请号：EP08723329.2

申请日：2008-03-07

申请人： Korea Institute of Oriental Medicine

发明人： KIM, Jin Sook ,  JANG, Dae Sik ,  LEE, Yun Mi ,  KIM, Jong Min ,  KIM, Young Sook ,  SHON, Eun Jin ,  KIM, Chan Sik ,  KIM, Jung Hyun ,  KIM, Ohn Soon ,  JUNG, Dong Ho ,  YOO, Jeong Lim ,  KIM, Joo Hwan

IPC分类号： A61K36/28 ,  A61P3/10 ,  A23L1/30

CPC分类号： A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

公开(公告)号：EP2131850A1

公开(公告)日：2009-12-16

申请号：EP08723329.2

申请日：2008-03-07

申请人： Korea Institute of Oriental Medicine

发明人： KIM, Jin Sook ,  JANG, Dae Sik ,  LEE, Yun Mi ,  KIM, Jong Min ,  KIM, Young Sook ,  SHON, Eun Jin ,  KIM, Chan Sik ,  KIM, Jung Hyun ,  KIM, Ohn Soon ,  JUNG, Dong Ho ,  YOO, Jeong Lim ,  KIM, Joo Hwan

IPC分类号： A61K36/28

CPC分类号： A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.