公开(公告)号：EP2722322B1

公开(公告)日：2019-06-12

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  A61P31/12 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61K31/04 ,  A61K31/47

摘要： The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP4360710A2

公开(公告)日：2024-05-01

申请号：EP23218086.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： A61P31/00

CPC分类号： C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C205/45 ,  C07C323/22 ,  C07C225/20 ,  C07C225/22 ,  C07C233/41 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/738 ,  C07C69/78 ,  C07C49/747 ,  C07C49/753 ,  C07D215/20 ,  C07D213/65 ,  C07C2601/0220170501 ,  C07C2602/0820170501 ,  C07D221/04 ,  A61P11/02 ,  A61P17/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/16 ,  A61P3/10 ,  A61P9/00 ,  Y02A50/30

摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：EP2722322A2

公开(公告)日：2014-04-23

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven, K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C13/465 ,  A61K31/04 ,  A61K31/47 ,  A61P31/12

摘要： The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP4360710A3

公开(公告)日：2024-08-07

申请号：EP23218086.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61P31/12 ,  A61K31/04 ,  A61K31/47

CPC分类号： C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C205/45 ,  C07C323/22 ,  C07C225/20 ,  C07C225/22 ,  C07C233/41 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/738 ,  C07C69/78 ,  C07C49/747 ,  C07C49/753 ,  C07D215/20 ,  C07D213/65 ,  C07C2601/0220170501 ,  C07C2602/0820170501 ,  C07D221/04 ,  A61P11/02 ,  A61P17/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/16 ,  A61P3/10 ,  A61P9/00 ,  Y02A50/30

摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：EP2722322B8

公开(公告)日：2020-03-11

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  A61P31/12 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61K31/04 ,  A61K31/47

公开(公告)号：EP3611158A1

公开(公告)日：2020-02-19

申请号：EP19179546.7

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61P31/12 ,  A61K31/04 ,  A61K31/47

摘要： Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.