公开(公告)号：EP1244800B1

公开(公告)日：2007-03-14

申请号：EP00990461.6

申请日：2000-10-30

申请人： Kosan Biosciences, Inc.

发明人： KATZ, Leonard ,  LIU, Lu ,  CHUNG, Loleta, M.

IPC分类号： C12N15/76 ,  C07D498/18 ,  A61K31/435

CPC分类号： C07D498/18 ,  C12N9/1029 ,  C12N15/52 ,  C12P17/188

摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.

公开(公告)号：EP1244800A1

公开(公告)日：2002-10-02

申请号：EP00990461.6

申请日：2000-10-30

申请人： Kosan Biosciences, Inc.

发明人： KATZ, Leonard ,  LIU, Lu ,  CHUNG, Loleta, M.

IPC分类号： C12N15/76 ,  C07D498/18 ,  A61K31/435

CPC分类号： C07D498/18 ,  C12N9/1029 ,  C12N15/52 ,  C12P17/188

摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.