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公开(公告)号：EP1320611B1
公开(公告)日：2005-11-09
申请号：EP01973782.4
申请日：2001-04-26
发明人： ARSLANIAN, Robert, L. , ASHLEY, Gary , FRYKMAN, Scott , JULIEN, Bryan , KATZ, Leonard , KHOSLA, Chaitan , LAU, Janice , LICARI, Peter, J. , REGENTIN, Rika , SANTI, Daniel , TANG, Li
IPC分类号： C12N15/52 , C12N15/74 , C12N9/00 , C12N1/21 , C12P17/16 , C12P17/18 , C07D313/00 , C07D413/06 , C07D417/06 , C07D493/04 , C07D493/06
CPC分类号： C12P17/181 , C07D313/00 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07D493/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/16 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
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公开(公告)号：EP1831204A2
公开(公告)日：2007-09-12
申请号：EP05854506.2
申请日：2005-12-16
发明人： TIAN, Zong-Qiang , MYLES, David, C. , WANG, Zhan , XU, Yuan , JULIEN, Bryan , RODRIGUEZ, Eduardo , SHIMAZU, Mark , BUCHANAN, Greg, O. , KATZ, Leonard
IPC分类号： C07D407/08 , A61K31/351 , C12P17/06 , C12N1/21
CPC分类号： C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12
摘要： Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.
摘要翻译： 式I代表的抗真菌化合物，其中R1，R2，R3和R4如本文所定义。 分离或纯化的天然存在的20,21-二氢安替比林化合物。 本发明还提供纤维堆囊菌ambM，ambO，ambP和ambS突变株; 产生24-norambruticin化合物的重组纤维索氏菌菌株; 以及使用本发明的化合物治疗真菌感染的方法。
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公开(公告)号：EP1224317B1
公开(公告)日：2006-03-08
申请号：EP00973861.8
申请日：2000-10-25
发明人： KATZ, Leonard , REVILL, Peter
摘要： Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.
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公开(公告)号：EP1244800A1
公开(公告)日：2002-10-02
申请号：EP00990461.6
申请日：2000-10-30
发明人： KATZ, Leonard , LIU, Lu , CHUNG, Loleta, M.
IPC分类号： C12N15/76 , C07D498/18 , A61K31/435
CPC分类号： C07D498/18 , C12N9/1029 , C12N15/52 , C12P17/188
摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.
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公开(公告)号：EP1320611A2
公开(公告)日：2003-06-25
申请号：EP01973782.4
申请日：2001-04-26
发明人： ARSLANIAN, Robert, L. , ASHLEY, Gary , FRYKMAN, Scott , JULIEN, Bryan , KATZ, Leonard , KHOSLA, Chaitan , LAU, Janice , LICARI, Peter, J. , REGENTIN, Rika , SANTI, Daniel , TANG, Li
IPC分类号： C12N15/52 , C12N15/74 , C12N9/00 , C12N1/21 , C12P17/16 , C12P17/18 , C07D313/00 , C07D413/06 , C07D417/06 , C07D493/04 , C07D493/06
CPC分类号： C12P17/181 , C07D313/00 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/04 , C07D493/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/16 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
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公开(公告)号：EP1224317A2
公开(公告)日：2002-07-24
申请号：EP00973861.8
申请日：2000-10-25
发明人： KATZ, Leonard , REVILL, Peter
摘要： Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.
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公开(公告)号：EP1244800B1
公开(公告)日：2007-03-14
申请号：EP00990461.6
申请日：2000-10-30
发明人： KATZ, Leonard , LIU, Lu , CHUNG, Loleta, M.
IPC分类号： C12N15/76 , C07D498/18 , A61K31/435
CPC分类号： C07D498/18 , C12N9/1029 , C12N15/52 , C12P17/188
摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.
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8.发明公开RECOMBINANT METHODS AND MATERIALS FOR PRODUCING EPOTHILONE AND EPOTHILONE DERIVATIVES 审中-公开用于制备重组方法和产品，埃博霉素衍生物埃博霉素
公开(公告)号：EP1135470A2
公开(公告)日：2001-09-26
申请号：EP99960500.9
申请日：1999-11-19
发明人： JULIEN, Bryan , KATZ, Leonard , KHOSLA, Chaitan , TANG, Li , ZIERMANN, Rainer
CPC分类号： C07D417/06 , C07D493/04 , C07D493/08 , C07D513/08 , C12N15/1058 , C12N15/52 , C12P17/181
摘要： Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) of sorangium cellulosum are used to express recombinant PKS genes in host cells for the production of epithilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
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