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1.发明授权METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMITOTICS 有权方法与HSP90消炎药疾病杂志与抗有丝分裂结合物处理
公开(公告)号：EP1628667B1
公开(公告)日：2009-07-29
申请号：EP04753672.7
申请日：2004-05-28
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
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2.发明授权METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMETABOLITES 有权方法与HSP90消炎药疾病的联合抗代谢物治疗
公开(公告)号：EP1631267B1
公开(公告)日：2008-01-02
申请号：EP04776158.0
申请日：2004-05-28
IPC分类号： A61K31/33 , A61K31/505
CPC分类号： A61K31/513 , A61K31/395 , A61K31/522 , A61K31/525 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimetabolite, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimetabolite in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimetabolite. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimetabolite and subsequently treated with a dose of an HSP90 inhibitor.
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3.发明公开METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMITOTICS 有权方法与HSP90消炎药疾病杂志与抗有丝分裂结合物处理
公开(公告)号：EP1628667A1
公开(公告)日：2006-03-01
申请号：EP04753672.7
申请日：2004-05-28
IPC分类号： A61K31/535
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
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4.发明公开METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ENZYME INHIBITORS 审中-公开方法与HSP90消炎药疾病的结合酶抑制剂治疗
公开(公告)号：EP1628623A2
公开(公告)日：2006-03-01
申请号：EP04753673.5
申请日：2004-05-28
IPC分类号： A61K6/00
CPC分类号： A61K31/165 , A61K31/395 , A61K31/517
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an enzyme inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an enzyme inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an enzyme inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an enzyme inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
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5.发明公开METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH ANTIMETABOLITES 有权方法与HSP90消炎药疾病的联合抗代谢物治疗
公开(公告)号：EP1631267A2
公开(公告)日：2006-03-08
申请号：EP04776158.0
申请日：2004-05-28
IPC分类号： A61K31/00
CPC分类号： A61K31/513 , A61K31/395 , A61K31/522 , A61K31/525 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimetabolite, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimetabolite in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimetabolite. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimetabolite and subsequently treated with a dose of an HSP90 inhibitor.
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6.发明公开METHOD FOR TREATING DISEASES USING HSP90-INHIBITING AGENTS IN COMBINATION WITH PLATINUM COORDINATION COMPLEXES 审中-公开17烷基氨基-17- desmethoxygeldanamycin和奥沙利铂在乳腺癌和结肠直肠癌的治疗中的用途
公开(公告)号：EP1628657A2
公开(公告)日：2006-03-01
申请号：EP04753658.6
申请日：2004-05-28
CPC分类号： A61K33/24 , A61K31/28 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a platinum coordination complex, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a platinum coordination complex in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a platinum coordination complex. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a platinum coordination complex and subsequently treated with a dose of an HSP90 inhibitor.
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