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    Process for the preparation of a bispyridiniumalkane-containing semisolid preparation
    3.
    发明公开
    Process for the preparation of a bispyridiniumalkane-containing semisolid preparation 审中-公开
    韦法罕zur Herstellung einer bispyridiniumalkanhaltigen halbfesten Zubereitung

    公开(公告)号：EP2702983A1

    公开(公告)日：2014-03-05

    申请号：EP13179624.5

    申请日：2013-08-07

    申请人： L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE ,  SCHÜLKE & MAYR GMBH

    发明人： Behrends, Sabine ,  Dettmann, Andreas ,  Radischat, Nadine ,  Hahn, Mona

    IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K9/06 ,  A61K47/44 ,  C11D3/48 ,  A61K31/4425

    CPC分类号： A61K9/0043 ,  A61K9/06 ,  A61K31/4425 ,  A61K47/10 ,  A61K47/14

    摘要： The invention relates to a process for preparing a semisolid preparation which contains bispyridiniumalkane, in which process a) the bispyridiniumalkane is dissolved in solvent so as to prepare a solution of the bispyridiniumalkane, and b) the solution of the bispyridiniumalkane is mixed with one or more further customary constituents of a semisolid preparation. It is preferred to employ octenidin dihydrochloride as the bispyridiniumalkane. Furthermore, the invention relates to semisolid preparations, prepared by the process, in the form of a concentrate, in the form of a use preparation or as a kit. In particular, the semisolid preparation is applied to the nasal mucosa for controlling MRP and its activity is comparable to that of mupirocin-based preparations.

    摘要翻译： 本发明涉及一种制备含有双吡啶基烷烃的半固体制剂的方法，其中a）将双吡啶鎓烷烃溶解在溶剂中以制备双吡啶烷基烷烃的溶液，和b）将双吡啶烷烃的溶液与一种或多种 半固体制剂的进一步习惯成分。 优选使用辛烯啶二盐酸盐作为双吡啶鎓烷烃。 此外，本发明涉及通过该方法以浓缩物的形式，以使用制剂或试剂盒的形式制备的半固体制剂。 特别地，半固体制剂应用于鼻粘膜以控制MRP，其活性与基于莫匹罗星的制剂相当。

    Stabilized, antimicrobially effective composition with a content of bispyridinium alkane
    4.
    发明公开
    Stabilized, antimicrobially effective composition with a content of bispyridinium alkane 有权
    Stabilisierte，antimikrobiell wirksame Zusammensetzung mit einem Anteil a Bispyridiniumalkan

    公开(公告)号：EP2656734A2

    公开(公告)日：2013-10-30

    申请号：EP13174331.2

    申请日：2009-02-18

    申请人： Air Liquide Santé (International) ,  SCHÜLKE & MAYR GMBH

    发明人： Beilfuss, Wolfgang ,  Behrends, Sabine ,  Hahn, Mona ,  Spuida, Thomas ,  Kassens, Elke ,  Dettmann, Andreas

    IPC分类号： A01N25/22 ,  A01N25/30 ,  A01N43/40 ,  A61K8/49 ,  A61Q11/00 ,  A01P1/00 ,  A61K31/4425 ,  A61Q17/00

    CPC分类号： A61K31/4425 ,  A01N43/40 ,  A61K8/4926 ,  A61Q11/00 ,  A61Q17/005 ,  A01N25/22 ,  A01N25/30 ,  A01N2300/00

    摘要： The invention provides an aqueous-based composition which comprises a) at least one bispyridinium alkane (for example octenidine) and b) at least one stabilizer selected from antioxidants, complexing agents, reducing agents, UV filters and photoprotective agents, in particular α-tocopherol, and BHT. The composition can also comprise c) one or more auxiliaries selected from, for example, nonionic surfactants, ethers, solvents and polymers, in particular fatty alcohol alkoxylates and alkoxylated fatty acid monoglycerides. The presence of the stabilizer reduces or prevents the appearance of decomposition products of bispyridinium alkanes and, in the case of the presence of auxiliaries, of decomposition products of the auxiliaries, such as ethers and peroxides.

    摘要翻译： 本发明提供一种含水基组合物，其包含a）至少一种双吡啶烷烃（例如，辛烯尼酸）和b）至少一种选自抗氧化剂，络合剂，还原剂，UV过滤器和光保护剂的稳定剂，特别是±生育酚 ，和BHT。 组合物还可包含c）一种或多种选自例如非离子表面活性剂，醚，溶剂和聚合物，特别是脂肪醇烷氧基化物和烷氧基化脂肪酸单甘油酯的助剂。 稳定剂的存在降低或防止双吡啶烷烃的分解产物的出现，以及在助剂的存在的情况下，助剂如醚和过氧化物的分解产物。

    KIT FOR COLOURING DISINFECTED REGIONS OF A SURFACE
    5.
    发明公开
    KIT FOR COLOURING DISINFECTED REGIONS OF A SURFACE 审中-公开
    KIT ZUMFÄRBENDESINFIZIERTER REGIONEN EINEROBERFLÄCHE

    公开(公告)号：EP2952213A1

    公开(公告)日：2015-12-09

    申请号：EP15164321.0

    申请日：2015-04-20

    申请人： L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE ,  SCHÜLKE & MAYR GMBH

    发明人： Behrends, Sabine ,  Hahn, Mona ,  Steinhorst, Nicole

    IPC分类号： A61L2/00 ,  A61L2/28

    CPC分类号： C11D3/48 ,  C11D3/40 ,  C11D17/04

    摘要： The invention relates to a kit for the coloring of disinfected areas of a surface, the kit comprising
    a) at least one swab of surgical gauze and
    b) liquid disinfectant,
    wherein the swab is dry and is dyed with colorant, and the liquid disinfectant, when brought in contact with the at least one dry swab, dissolves the colorant at least partially, to result in a swab impregnated with colored disinfectant.
    According to the invention, kits can be put together such that customary swabs from surgical gauze can be dyed. The colorant is then dissolved from the swab using the disinfectant, so as to result in a colored disinfectant. The colored disinfectant can be used to indicate disinfected areas.

    摘要翻译： 本发明涉及一种用于着色表面消毒区域的试剂盒，该试剂盒包括a）至少一个手术纱布拭子和b）液体消毒剂，其中拭子干燥并用着色剂染色，液体消毒剂， 当与至少一个干拭子接触时，至少部分地溶解着色剂，导致用彩色消毒剂浸渍的拭子。 根据本发明，可以将试剂盒放在一起，使得可以染色来自外科纱布的常规拭子。 然后使用消毒剂将着色剂从拭子溶解，以得到有色消毒剂。 彩色消毒剂可用于指示消毒区域。