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1.发明公开INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS 有权吲唑，异恶唑和异噻唑及其作为代理环境雌激素
公开(公告)号：EP1812404A1
公开(公告)日：2007-08-01
申请号：EP05794749.1
申请日：2005-10-14
申请人： LABORATOIRE THERAMEX
发明人： RONDOT, Benoît , LAFAY, Jean , BONNET, Paule , CLERC, Thierry , DUC, Igor , DURANTI, Eric , PUCCIO, François , SHIELDS, Jacqueline , BLOT, Christian , MAILLOS, Philippe
IPC分类号： C07D231/56 , C07D491/06 , C07D261/20 , C07D275/04 , C07D275/06 , A61K31/416 , A61K31/4162 , A61K31/423 , A61K31/428 , A61P5/30
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
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2.发明公开
公开(公告)号：EP1572665A2
公开(公告)日：2005-09-14
申请号：EP03795984.8
申请日：2003-12-15
申请人： LABORATOIRE THERAMEX
发明人： ADJE, Nathalie , BONNET, Paule , CARNIATO, Denis , LAFAY, Jean , DELANSORNE, Rémi , PASCAL, Jean-Claude
IPC分类号： C07D233/54 , A61K31/4164 , A61P43/00
CPC分类号： A01N43/56 , C07D231/14 , C07D231/16 , C07D231/38 , C07D231/40
摘要： The present invention relates to imidazole derivatives of the formula: (I) in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification.The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.
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3.发明授权INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS 有权吲唑，异恶唑和异噻唑及其作为代理环境雌激素
公开(公告)号：EP1812404B1
公开(公告)日：2011-06-15
申请号：EP05794749.1
申请日：2005-10-14
申请人： LABORATOIRE THERAMEX
发明人： RONDOT, Benoît , LAFAY, Jean , BONNET, Paule , CLERC, Thierry , DUC, Igor , DURANTI, Eric , PUCCIO, François , SHIELDS, Jacqueline , BLOT, Christian , MAILLOS, Philippe
IPC分类号： C07D231/56 , C07D491/06 , C07D261/20 , C07D275/04 , C07D275/06 , A61K31/416 , A61K31/4162 , A61K31/423 , A61K31/428 , A61P5/30
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
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公开(公告)号：EP1644350A1
公开(公告)日：2006-04-12
申请号：EP03816954.6
申请日：2003-05-16
申请人： LABORATOIRE THERAMEX
发明人： LAFAY, Jean , RONDOT, Benoît , CARNIATO, Denis , BONNET, Paule , CLERC, Thierry , SHIELDS, Jacqueline , DUC, Igor , DURANTI, Eric
IPC分类号： C07D333/54 , C07D333/76 , A61K31/381 , A61P35/00
CPC分类号： C07D333/54 , C07D333/76
摘要： The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.
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5.发明授权
公开(公告)号：EP2534165B1
公开(公告)日：2013-07-24
申请号：EP11702245.9
申请日：2011-02-08
申请人： Laboratoire Theramex
发明人： MOUTOU, Jean-Luc , MOUTON, Florent , PELLEGRINO, Gilles , DILLENSCHNEIDER, Jean-Marc , LAFAY, Jean
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , C07J1/0059
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6.发明公开
公开(公告)号：EP2534165A2
公开(公告)日：2012-12-19
申请号：EP11702245.9
申请日：2011-02-08
申请人： Laboratoire Theramex
发明人： MOUTOU, Jean-Luc , MOUTON, Florent , PELLEGRINO, Gilles , DILLENSCHNEIDER, Jean-Marc , LAFAY, Jean
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , C07J1/0059
摘要： The invention relates to a process for the preparation of a compound of formula (I): wherein R
1 and R
2 are as defined in the description, by reaction of a compound of formula (II) with a base. Compound (I) is an intermediate useful in the preparation of gestodene.-
7.发明授权
公开(公告)号：EP1644350B1
公开(公告)日：2009-07-01
申请号：EP03816954.6
申请日：2003-05-16
申请人： LABORATOIRE THERAMEX
发明人： LAFAY, Jean , RONDOT, Benoît , CARNIATO, Denis , BONNET, Paule , CLERC, Thierry , SHIELDS, Jacqueline , DUC, Igor , DURANTI, Eric
IPC分类号： C07D333/54 , C07D333/76 , A61K31/381 , A61P35/00
CPC分类号： C07D333/54 , C07D333/76
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8.发明公开1-N-PHENYL-AMINO-1H-IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开1-N - 苯基氨基-1H-咪唑衍生物及其药物组合物含
公开(公告)号：EP1694650A1
公开(公告)日：2006-08-30
申请号：EP04804432.5
申请日：2004-12-15
申请人： LABORATOIRE THERAMEX
发明人： LAFAY, Jean , RONDOT, Benoît , BONNET, Paule , CLERC, Thierry , SHIELDS, Jacqueline , DUC, Igor , DURANTI, Eric , PUCCIO, François , BLOT, Christian , MAILLOS, Philippe
IPC分类号： C07D233/56 , C07D409/12 , C07D419/12 , A61K31/4164 , A61K31/5415 , A61P5/00 , A61P35/00
CPC分类号： C07D233/54 , C07D409/12 , C07D419/12
摘要： The invention relates to the compounds of formula (I), in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds. The invention generally relates to the field of hormone- and non hormone-dependent cancer and endocrine disorders.
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9.发明授权
公开(公告)号：EP1572665B1
公开(公告)日：2006-05-03
申请号：EP03795984.8
申请日：2003-12-15
申请人： LABORATOIRE THERAMEX
发明人： ADJE, Nathalie , BONNET, Paule , CARNIATO, Denis , LAFAY, Jean , DELANSORNE, Rémi , PASCAL, Jean-Claude
IPC分类号： C07D233/54 , A61K31/4164 , A61P43/00
CPC分类号： A01N43/56 , C07D231/14 , C07D231/16 , C07D231/38 , C07D231/40
摘要： The present invention relates to imidazole derivatives of the formula: (I) in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification.The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.
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公开(公告)号：EP0886645B1
公开(公告)日：1999-09-01
申请号：EP97902235.7
申请日：1997-01-17
申请人： LABORATOIRE THERAMEX
CPC分类号： C07J7/0045 , C07J21/006 , C07J41/0016 , C07J53/004 , C07J71/001
摘要： The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5, R6, n and X are as defined in the specification, and to pharmaceutical compositions containing them. These compounds are excellent progestogens which are devoid of residual androgenic activity.
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