公开(公告)号：EP0204833A4

公开(公告)日：1988-02-03

申请号：EP86900478

申请日：1985-12-10

申请人： LAWRENCE PAUL J

发明人： LAWRENCE PAUL J

IPC分类号： C12Q1/28 ,  G01N33/72

CPC分类号： G01N33/725 ,  C12Q1/28 ,  C12Q2326/00 ,  C12Q2326/30 ,  Y10S436/904

公开(公告)号：EP0267952A4

公开(公告)日：1989-06-27

申请号：EP87903812

申请日：1987-06-01

申请人： LAWRENCE PAUL J

发明人： LAWRENCE PAUL J

IPC分类号： G01N33/50 ,  C12Q1/28

CPC分类号： C12Q1/28

摘要： Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50 % by volume of a solvent for iron protoporphyrins. In a preferred embodiment, the solvent for iron protoporphyrins comprises a mixture of a neutralized amine and an organic co-solvent. Alternatively, the solvent may comprise pyridine, an amide, a sulfoxide or sulfone, or mixtures thereof. Test results may be improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.