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1.发明授权PREPARATION OF NEW PHARMACEUTICALLY SUITABLE SALT OF LOSARTAN AND FORMS THEREOF WITH NEW PURIFICATION AND ISOLATION METHODS 有权新药剂SUITABLE氯沙坦盐的产品及其形成了由新的清洁和隔离方法
公开(公告)号：EP1589966B1
公开(公告)日：2010-11-10
申请号：EP04706411.8
申请日：2004-01-29
发明人： ANTONCIC, Ljubomir , COPAR, Anton , SVETE, Peter , HUSU-KOVACECIC, Breda , HAM, Zoran , MAROLT, Boris
IPC分类号： A61K31/4178 , A61P9/12 , C07D403/10
CPC分类号： C07D403/10
摘要： Pharmaceutically suitable crystalline and amorphous alkali and earth-alkali salts of 2-n-butyl-4-chloro-5-h idroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 Himidazole have been prepared and new manufacturing, purification and isolation procedure for said salts in high purity have been described. Stable pharmaceutical compositions containing new crystalline potassium salts of 2-n-butyl-4-chloro-5hidroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 H-imidazole have been prepared.
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公开(公告)号：EP1615884B1
公开(公告)日：2016-06-29
申请号：EP04726842.0
申请日：2004-04-09
发明人： ANTONCIC, Ljubomir , SORSAK, Gorazd , COPAR, Anton
IPC分类号： C07D207/34
CPC分类号： C07D207/34
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3.发明授权PROCESS FOR PREPARING AMORPHOUS (4R-CIS)-6-[2-[3-PHENYL-4-(PHENYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYL)-PYRROL-1-YL]-2,2-DIMETHYL-[1,3]-DIOXANE-4-YL-ACETIC ACID 有权PROCESS FOR无定形的（4R-顺）的制备-6- [2- [3-苯基-4-（苯基氨基甲酰基）-2-（4-氟苯基）-5-（1-甲基）吡咯-1-基] - 2,2-二甲基 - [1,3]二恶烷-4-基 - 乙酸
公开(公告)号：EP1711489B1
公开(公告)日：2012-12-26
申请号：EP04809253.0
申请日：2004-12-27
发明人： ANTONCIC, Ljubomir , SORSAK, Gorazd
IPC分类号： C07D405/06 , C07D207/34
CPC分类号： C07D405/06 , C07D207/34
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公开(公告)号：EP1812422A1
公开(公告)日：2007-08-01
申请号：EP05802257.5
申请日：2005-11-09
发明人： ANTONCIC, Ljubomir
IPC分类号： C07D403/10 , A61K31/415
CPC分类号： C07D403/10
摘要： New form of irbesartan having favourable chargeability is prepared from the alcoholic/etheric or ketonic solution of irbesartan after slow cooling with sporadic or light agitation and alternatively new crystalline form of an acid addition salt of irbesartan is prepared from the aqueous solution of a sodium salt of irbesartan after strongly acidifying aforesaid solution and subsequently adjusting pH with an alkali. Those are used in manufacturing a pharmaceutical composition.
摘要翻译： 具有良好带电性的厄贝沙坦的新形式是在用散发性或轻度搅拌的缓慢冷却后从厄贝沙坦的醇/醚或酮溶液制备的，或者备选地厄贝沙坦的酸加成盐的新结晶形式由 将上述溶液强酸化并随后用碱调节pH的厄贝沙坦。 这些用于制造药物组合物。
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5.发明公开PREPARATION OF NEW PHARMACEUTICALLY SUITABLE SALT OF LOSARTAN AND FORMS THEREOF WITH NEW PURIFICATION AND ISOLATION METHODS 有权新药剂SUITABLE氯沙坦盐的产品及其形成了由新的清洁和隔离方法
公开(公告)号：EP1589966A2
公开(公告)日：2005-11-02
申请号：EP04706411.8
申请日：2004-01-29
发明人： ANTONCIC, Ljubomir , COPAR, Anton , SVETE, Peter , HUSU-KOVACECIC, Breda , HAM, Zoran , MAROLT, Boris
IPC分类号： A61K31/4178 , A61P9/12 , C07D403/10
CPC分类号： C07D403/10
摘要： Pharmaceutically suitable crystalline and amorphous alkali and earth-alkali salts of 2-n-butyl-4-chloro-5-h idroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 Himidazole have been prepared and new manufacturing, purification and isolation procedure for said salts in high purity have been described. Stable pharmaceutical compositions containing new crystalline potassium salts of 2-n-butyl-4-chloro-5hidroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 H-imidazole have been prepared.
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公开(公告)号：EP1812422B1
公开(公告)日：2013-12-25
申请号：EP05802257.5
申请日：2005-11-09
发明人： ANTONCIC, Ljubomir
IPC分类号： C07D403/10 , A61K31/415
CPC分类号： C07D403/10
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7.发明公开A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS 审中-公开4-溴甲基-2'-甲酰基和4-溴甲基-2'-羟基联苯和它们在血管紧张素II拮抗剂的制造合成
公开(公告)号：EP1871764A1
公开(公告)日：2008-01-02
申请号：EP06707654.7
申请日：2006-03-30
IPC分类号： C07D403/04 , C07D235/02 , C07D417/08
CPC分类号： C07D235/02 , C07C33/46 , C07C45/44 , C07C47/55 , C07D403/04 , C07D417/08 , C07C47/546
摘要： 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2'-cyanobiphenyl or 4'- bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
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公开(公告)号：EP1812423A1
公开(公告)日：2007-08-01
申请号：EP05808670.3
申请日：2005-11-09
IPC分类号： C07D403/10
CPC分类号： C07D403/10 , Y02P20/55
摘要： A process for the synthesis of tetrazol derivative has been developed which starts from a tetrazole derivative where acidic hydrogen atom has been replaced by a protecting group and the deprotection is performed with a catalytic amount of organic acid and can proceed in an aqueous solvent.
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9.发明公开PROCESS FOR PREPARING AMORPHOUS (4R-CIS)-6-[2-[3-PHENYL-4-(PHENYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYL)-PYRROL-1-YL]-2,2-DIMETHYL-[1,3]-DIOXANE-4-YL-ACETIC ACID 有权PROCESS FOR无定形的（4R-顺）的制备-6- [2- [3-苯基-4-（苯基氨基甲酰基）-2-（4-氟苯基）-5-（1-甲基）吡咯-1-基] - 2,2-二甲基 - [1,3]二恶烷-4-基 - 乙酸
公开(公告)号：EP1711489A1
公开(公告)日：2006-10-18
申请号：EP04809253.0
申请日：2004-12-27
发明人： ANTONCIC, Ljubomir , SORSAK, Gorazd
IPC分类号： C07D405/06 , C07D207/34
CPC分类号： C07D405/06 , C07D207/34
摘要： The invention relates to a process of preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid - tertiary butyl ester which is a useful pharmaceutical intermediate in the preparation of atorvastatin salts.
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公开(公告)号：EP1615884A1
公开(公告)日：2006-01-18
申请号：EP04726842.0
申请日：2004-04-09
发明人： ANTONCIC, Ljubomir , SORSAK, Gorazd , COPAR, Anton
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Present invention refers to the process of preparing amorphous atorvastatin calcium without intermediate isolation of crystal or undefined mixture of crystal and amorphous atorvastatin calcium, respectively. Forming of calcium atorvastatin salt is carried out in a mixture of chlorinated organic solvent or cyclic hydrocarbon solvent, respectively, the non-hydroxylic organic solvent, and water, the source of calcium ions is calcium acetate or calcium chloride, respectively.
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