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1.发明公开
公开(公告)号：EP2515884A1
公开(公告)日：2012-10-31
申请号：EP10790577.0
申请日：2010-12-20
发明人： BELE, Marjan , GABERSCEK, Miran , JAMNIK, Janko , ZORKO, Milena , MAVER, Uros , KOCEVAR, Klemen
IPC分类号： A61K9/50 , A61K31/192 , A61K31/501 , A61K31/519 , A61K31/7048
CPC分类号： A61J3/005 , A61K9/501 , A61K9/5089 , A61K31/192 , A61K31/501 , A61K31/519 , A61K31/7048
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a process for coating a particle comprising a pharmaceutically active ingredient (API) comprising the steps of providing a composition comprising carbonate ions, phosphate ions, or a mixture thereof, providing a particle comprising an API, and precipitating a carbonate salt, a phosphate salt or a mixture thereof onto said particles. The present invention is also directed to a particle comprising an API, wherein the particle is coated with a coating comprising a carbonate salt, phosphate salt, or mixture thereof, and to a pharmaceutical composition comprising said particles. Moreover, the present invention is also directed to the use of said particles for preparing a medicament.
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公开(公告)号：EP2040684A2
公开(公告)日：2009-04-01
申请号：EP07765142.0
申请日：2007-07-09
IPC分类号： A61K9/20
CPC分类号： A61K9/5078 , A61K9/2018 , A61K9/2054 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5084 , A61K47/34
摘要： The present invention relates to multiple unit tablets comprising multiple units compacted together with at least two tablet filler-binders and optionally other pharmaceutically acceptable excipients, wherein at least one of said tablet filler-binder is a tablet filler-binder having mean particle size-to-mean multiple unit size ratio from 10% to 40%, and at least one of said tablet filler-binder is a tablet filler-binder having mean particle size-to-mean multiple unit size ratio from 1 % to 10%. The present invention further relates to process for the preparation of multiple unit tablets.
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公开(公告)号：EP2347242B1
公开(公告)日：2015-09-23
申请号：EP09740704.3
申请日：2009-10-28
发明人： LEGEN, Igor , KOCEVAR, Klemen
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006
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4.发明公开
公开(公告)号：EP2515885A1
公开(公告)日：2012-10-31
申请号：EP10792942.4
申请日：2010-12-20
发明人： BELE, Marjan , GABERSCEK, Miran , MAVER, Uros , KOCEVAR, Klemen
IPC分类号： A61K9/50 , A61K31/192 , A61K31/501 , A61K31/519 , A61K31/7048
CPC分类号： A61J3/005 , A61K9/501 , A61K9/5089 , A61K31/192 , A61K31/501 , A61K31/519 , A61K31/7048
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a process for coating a particle comprising a pharmaceutically active ingredient (API) comprising the steps of providing a composition comprising carbonate ions, phosphate ions, or a mixture thereof, providing a particle comprising an API, and precipitating a carbonate salt, a phosphate salt or a mixture thereof onto said particles. The present invention is also directed to a particle comprising an API, wherein the particle is coated with a coating comprising a carbonate salt, phosphate salt, or mixture thereof, and to a pharmaceutical composition comprising said particles. Moreover, the present invention is also directed to the use of said particles for preparing a medicament.
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公开(公告)号：EP2040684B1
公开(公告)日：2013-01-23
申请号：EP07765142.0
申请日：2007-07-09
IPC分类号： A61K9/20
CPC分类号： A61K9/5078 , A61K9/2018 , A61K9/2054 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5084 , A61K47/34
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公开(公告)号：EP1594474A2
公开(公告)日：2005-11-16
申请号：EP04710142.3
申请日：2004-02-11
发明人： HUMAR, Vlasta , BURJAK, Mateja , GRAHEK, Rok , SALOBIR, Mateja , KERC, Janez , KOCEVAR, Klemen
CPC分类号： A61K9/5047 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K31/40
摘要： The present invention relates to coated particles and pharmaceutical dosage forms comprising the active substances sensitive to environmental influences. The coating of the present invention provides stability and protection of the active substance to environmental influences and in particular from oxidation and/or environmental humidity by coating.
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7.发明授权
公开(公告)号：EP1594474B1
公开(公告)日：2017-03-22
申请号：EP04710142.3
申请日：2004-02-11
发明人： HUMAR, Vlasta , BURJAK, Mateja , GRAHEK, Rok , SALOBIR, Mateja , KERC, Janez , KOCEVAR, Klemen
CPC分类号： A61K9/5047 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K31/40
摘要： The present invention relates to coated particles and pharmaceutical dosage forms comprising the active substances sensitive to environmental influences. The coating of the present invention provides stability and protection of the active substance to environmental influences and in particular from oxidation and/or environmental humidity by coating.
摘要翻译： 本发明涉及包含对环境影响敏感的活性物质的包衣颗粒和药物剂型。 本发明的涂层提供了活性物质对于环境影响的稳定性和保护，特别是通过涂覆从氧化和/或环境湿度。
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公开(公告)号：EP2416775A1
公开(公告)日：2012-02-15
申请号：EP10713900.8
申请日：2010-04-06
IPC分类号： A61K31/4985 , A61K9/14 , A61K9/20 , A61K47/02
CPC分类号： A61K9/143 , A61K9/2009
摘要： Dosage forms comprising tadalafil adsorbed on a particulate carrier. Furthermore it is disclosed an adsorbate comprising tadalafil adsorbed on a particulate carrier. The present invention also refers to a process for the preparation of the adsorbate comprising the steps of (a) providing an API being practically insoluble in water; (b) providing solid support carrier particles; (c) placing the API and the carrier particles into a predetermined solvent which, allows adsorption of the API on the surface of carrier particles but gives substantially no precipitate, and (d) removing the solvent to form an API-carrier adsorbate. Furthermore the invention relates to a process for the preparation of the dosage form, as well as to the use of the adsorbate for the preparation of the dosage form. Moreover it relates to the dosage form for use in the treatment of erectile dysfunction, hypercholesterolemia, human immunodeficiency virus (HIV) infections and/or Acquired Immune Deficiency Syndrome (AIDS).
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公开(公告)号：EP2347242A1
公开(公告)日：2011-07-27
申请号：EP09740704.3
申请日：2009-10-28
发明人： LEGEN, Igor , KOCEVAR, Klemen
IPC分类号： G01N13/00
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006
摘要： The present invention relates to a concept for testing dissolution of an active pharmaceutical ingredient wherein two compartments separated by a membrane impregnated with a lipophilic phase are provided. The membrane is permeable to a dissolved state but impermeable to an undissolved state of said active pharmaceutical ingredient.
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